Thrombolysis in Myocardial Ischemia Trial (TIMI III)
Completed
National Heart, Lung, and Blood Institute (NHLBI)
Phase 3
1989-04-01
The Thrombolysis in Myocardial Ischemia Trial (TIMI III) focused on unstable angina and
non-Q-wave myocardial infarction. The trial was designed to determine by coronary
arteriography the incidence of coronary thrombi in these conditions and the response of these
thrombi to tissue-type plasminogen activator (t-PA) in TIMI IIIA and the effects of
thrombolytic therapy and of an early invasive strategy on clinical outcome in TIMI IIIB.
There was also a registry with two components. A roster enumerated all patients with unstable
angina or non-Q-wave myocardial infarction enrolled at cooperating hospitals. From the
roster, a study population of 1,893 subjects was selected and followed prospectively for the
year to determine incidence of death or myocardial infarction.
Do Fish Oils Prevent Restenosis Post-Coronary Angioplasty?
Completed
National Heart, Lung, and Blood Institute (NHLBI)
Phase 3
1989-07-01
To determine whether a dietary supplement of n-3 polyunsaturated fatty acids (PUFAs) derived
from fish oil would decrease the restenosis rate in patients undergoing percutaneous
transluminal coronary angioplasty (PTCA).
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Iloprost for Raynaud's Phenomenon Secondary to Systemic Sclerosis
Completed
University of Pittsburgh
Phase 3
1995-12-01
OBJECTIVES:
I. Evaluate the safety and efficacy of oral iloprost, a prostacyclin analog, in patients with
Raynaud's phenomenon secondary to systemic sclerosis.
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