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Generated: December 14, 2018

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CLINICAL TRIALS PROFILE FOR HALOTHANE

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Clinical Trials for Halothane

Trial ID Title Status Sponsor Phase Summary
NCT00815269 Vasodilation Effect of Inhalational Anesthetics Completed Nanjing Medical University N/A Previous studies on animals suggest that inhalational anesthetics can reduce vascular tension in vitro resulting in vasodilation and decrease in blood pressure. This role for inhalational anesthetics has essential clinical implications such as the condition of sepsis or septic shock or other shock-associated states during which the blood vessel constricts strongly and leads to circulation dysfunction. The vasodilation property of these anesthetics including halothane, isoflurane, sevoflurane, desflurane and enflurane enables them to be better options than other general anesthetics in many clinical conditions needing the vasculature to be dilated. The investigators hypothesized that these inhalational anesthetics can evoke vasodilation measured with ultrasonography during general anesthesia in vivo as the in vitro studies displayed.
NCT01235143 Emergence Agitation Between Sevoflurane and Desflurane in Pediatric Completed Prince of Songkla University N/A Sevoflurane is the volatile anesthetic agent of choice in pediatric surgery. Nevertheless, sevoflurane anesthesia had the high incidence of emergence delirium compared to halothane and isoflurane.Bortone L et al.reported isoflurane for maintenance decreased incidence of emergence agitation compared to sevoflurane in unpremedicated preschool children under elective subumbilical surgery (32% versus 52% respectively). Desflurane is the new volatile anesthetic agent which provides faster recovery compared to sevoflurane.Valley et al.reported no significant differences between sevoflurane or desflurane anesthesia in children in term of the serious airway complication such as laryngospasm or desaturation excepted the number of coughing episodes were more frequent in the desflurane compared to sevoflurane (36 versus 18).Mayer J et al. reported sevoflurane had severity of Pediatric Anesthesia Emergence Delirium (PAED) scale higher than desflurane in ear, nose, throat inpatient surgery in children (12(2-20) versus 6(0-15) respectively) with no reported of incidence of emergence agitation between those two. Therefore, the investigators would like to compare the incidence of emergence agitation, recovery profile and respiratory events between desflurane and sevoflurane anesthesia in pediatric ambulatory urologic surgery under general anesthesia and combined with regional anesthesia.
NCT01452256 Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery Completed Cantonal Hospital of St. Gallen Phase 4 Desflurane and its effect on postoperative morbidity and mortality in patients undergoing thoracic surgery. Halothane, enflurane, isoflurane, sevoflurane, and desflurane are volatile anesthetics, a group of general anesthetics. Because of the hypnotic effects of these agents, attention has mainly focused on the central nervous system. In the last 10 years, however, numerous studies have reported that volatile anesthetic agents interact with membrane structures of the myocardium and thereby attenuate cardiac mechanical dysfunction and limit ultrastructural abnormality on reperfusion after prolonged ischemia in the myocyte. Anesthetic-induced preconditioning has become a main topic in cardiac research worldwide - Trial with medicinal product
NCT01452256 Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery Completed Kantonsspital Münsterlingen Phase 4 Desflurane and its effect on postoperative morbidity and mortality in patients undergoing thoracic surgery. Halothane, enflurane, isoflurane, sevoflurane, and desflurane are volatile anesthetics, a group of general anesthetics. Because of the hypnotic effects of these agents, attention has mainly focused on the central nervous system. In the last 10 years, however, numerous studies have reported that volatile anesthetic agents interact with membrane structures of the myocardium and thereby attenuate cardiac mechanical dysfunction and limit ultrastructural abnormality on reperfusion after prolonged ischemia in the myocyte. Anesthetic-induced preconditioning has become a main topic in cardiac research worldwide - Trial with medicinal product
NCT01452256 Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery Completed University Hospital Inselspital, Berne Phase 4 Desflurane and its effect on postoperative morbidity and mortality in patients undergoing thoracic surgery. Halothane, enflurane, isoflurane, sevoflurane, and desflurane are volatile anesthetics, a group of general anesthetics. Because of the hypnotic effects of these agents, attention has mainly focused on the central nervous system. In the last 10 years, however, numerous studies have reported that volatile anesthetic agents interact with membrane structures of the myocardium and thereby attenuate cardiac mechanical dysfunction and limit ultrastructural abnormality on reperfusion after prolonged ischemia in the myocyte. Anesthetic-induced preconditioning has become a main topic in cardiac research worldwide - Trial with medicinal product
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Halothane

Condition Name

Condition Name for Halothane
Intervention Trials
Epidural Anesthesia 1
Postoperative Nausea and Vomiting 1
Agitation 1
Elderly Patients 1
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Condition MeSH

Condition MeSH for Halothane
Intervention Trials
Psychomotor Agitation 2
Postoperative Nausea and Vomiting 1
Mobility Limitation 1
Nausea 1
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Clinical Trial Locations for Halothane

Trials by Country

Trials by Country for Halothane
Location Trials
China 2
Switzerland 2
Brazil 1
Czechia 1
India 1
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Clinical Trial Progress for Halothane

Clinical Trial Phase

Clinical Trial Phase for Halothane
Clinical Trial Phase Trials
Phase 4 4
Phase 2/Phase 3 1
Phase 2 2
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Clinical Trial Status

Clinical Trial Status for Halothane
Clinical Trial Phase Trials
Completed 5
Recruiting 3
Active, not recruiting 1
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Clinical Trial Sponsors for Halothane

Sponsor Name

Sponsor Name for Halothane
Sponsor Trials
University Hospital, Basel, Switzerland 2
Government Medical College, Haldwani 1
Prince of Songkla University 1
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Sponsor Type

Sponsor Type for Halothane
Sponsor Trials
Other 23
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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
Harvard Business School
Healthtrust
Mallinckrodt
US Army
Teva
Johnson and Johnson
Chubb
Farmers Insurance

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