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CLINICAL TRIALS PROFILE FOR GRANISETRON HYDROCHLORIDE

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Clinical Trials for Granisetron Hydrochloride

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00003213	Drugs to Reduce the Side Effects of Chemotherapy	Completed	Swiss Group for Clinical Cancer Research	Phase 3	RATIONALE: Antiemetic drugs may help to reduce or prevent nausea and vomiting in patients treated with chemotherapy. It is not known whether receiving dexamethasone with granisetron is more effective than receiving dexamethasone with metoclopramide for reducing the side effects of chemotherapy. PURPOSE: Randomized phase III trial to compare the effectiveness of dexamethasone with either granisetron or metoclopramide in patients treated with chemotherapy.
NCT00004219	Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma	Unknown status	Simbec Research	Phase 3	RATIONALE: Antiemetic drugs may help to reduce or prevent nausea and vomiting in patients treated with radiation therapy. It is not yet known whether lerisetron is more effective than granisetron in preventing nausea and vomiting. PURPOSE: Randomized phase III trial to compare the effectiveness of lerisetron with that of granisetron in preventing nausea and vomiting in men who are being treated with radiation therapy for stage I seminoma.
NCT00005024	Granisetron to Prevent Nausea and Vomiting After Chemotherapy in Patients With Malignant Disease	Unknown status	National Cancer Institute (NCI)	Phase 3	RATIONALE: Antiemetic drugs such as granisetron may help to prevent nausea and vomiting in patients treated with chemotherapy. PURPOSE: Randomized phase III trial to compare the effectiveness of granisetron with that of a placebo in preventing nausea and vomiting after chemotherapy in patients who have malignant disease.
NCT00005024	Granisetron to Prevent Nausea and Vomiting After Chemotherapy in Patients With Malignant Disease	Unknown status	Jonsson Comprehensive Cancer Center	Phase 3	RATIONALE: Antiemetic drugs such as granisetron may help to prevent nausea and vomiting in patients treated with chemotherapy. PURPOSE: Randomized phase III trial to compare the effectiveness of granisetron with that of a placebo in preventing nausea and vomiting after chemotherapy in patients who have malignant disease.
NCT00020657	Comparison of Antiemetic Drugs in Preventing Delayed Nausea After Chemotherapy in Patients With Cancer	Completed	National Cancer Institute (NCI)	Phase 3	RATIONALE: Antiemetic drugs may help to reduce or prevent nausea and vomiting in patients being treated with chemotherapy. PURPOSE: This randomized phase III trial is comparing how well different antiemetic drugs work in preventing delayed nausea after chemotherapy in patients who have cancer.

Clinical Trial Conditions for Granisetron Hydrochloride

Condition Name

Condition Name for Granisetron Hydrochloride
Intervention	Trials
Nausea	11
Vomiting	10
Chemotherapy-Induced Nausea and Vomiting	9
Nausea and Vomiting	7

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Condition MeSH

Condition MeSH for Granisetron Hydrochloride
Intervention	Trials
Vomiting	43
Nausea	39
Postoperative Nausea and Vomiting	10
Breast Neoplasms	4

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Clinical Trial Locations for Granisetron Hydrochloride

Trials by Country

Trials by Country for Granisetron Hydrochloride
Location	Trials
United States	96
China	10
Canada	7
Korea, Republic of	5
Taiwan	4

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Trials by US State

Trials by US State for Granisetron Hydrochloride
Location	Trials
Michigan	7
Illinois	6
Massachusetts	5
North Carolina	5
Wisconsin	5

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Clinical Trial Progress for Granisetron Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Granisetron Hydrochloride
Clinical Trial Phase	Trials
Phase 4	14
Phase 3	22
Phase 2/Phase 3	1

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Clinical Trial Status

Clinical Trial Status for Granisetron Hydrochloride
Clinical Trial Phase	Trials
Completed	50
Recruiting	11
Unknown status	10

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Clinical Trial Sponsors for Granisetron Hydrochloride

Sponsor Name

Sponsor Name for Granisetron Hydrochloride
Sponsor	Trials
Prostrakan Pharmaceuticals	9
National Cancer Institute (NCI)	7
Merck Sharp & Dohme Corp.	6

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Sponsor Type

Sponsor Type for Granisetron Hydrochloride
Sponsor	Trials
Other	71
Industry	46
NIH	7

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