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Last Updated: October 4, 2024

CLINICAL TRIALS PROFILE FOR GONADORELIN HYDROCHLORIDE


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All Clinical Trials for Gonadorelin Hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01907009 ↗ A PHASEII STUDY EVALUATING INTRAVENOUS MELPHALAN WITH AUTOLOGOUS WHOLE BLOOD STEM CELL TRANSPLANTATION (PBSCT)OVER THREE CYCLES IN PATIENTS WITH CASTRATION-RESISTANT PROSTATE CANCER (MEL-CAP). Unknown status Barts & The London NHS Trust Phase 2/Phase 3 2013-01-01 The management of (castration-resistant) prostate cancer (CRPC) is becoming increasingly complex. The use of peripheral anti-androgens with gonadorelin analogues (maximum androgen blockade) is common place. Following the failure of such an approach, several strategies may be employed. Both corticosteroids and estrogens have a role and increasingly chemotherapy is being used. The demonstration of enhanced survival using 3 weekly docetaxel has meant that this is viewed by many as the standard of care for fit patients. Melphalan is an established alkylating drug that has demonstrated some activity in CRPC, but to date, myelosuppression has prevented adequate dosing. We have recently conducted a phase I dose escalation study using melphalan and whole blood stem cell re-infusion and it shows that median overall survival is 22 months, which is higher than the median survival rate of 19 months for Docetaxel Data from a previous phase I study has proved the successful administration of higher doses of IV Melphalan in combination with autologous blood infusion in patients with Castration-resistant prostate cancer. Rapid falls in circulating tumour cells were seen within 2 weeks of starting Melphalan, however slow platelet recovery meant longer periods of platelet transfusion. For this study we intend to assess the efficacy of an intensified intravenous melphalan with autologous whole blood stem cell transplantation over three treatment cycles. 39 patients will be enrolled over a 3 year period and at least 17 patients need to survive progression free at least 6-months for this study to be considered positive. Mel-CAP is a combination chemotherapy consisting of two chemotherapy drugs: MELPHALAN and LENOGRASTIM for 3 cycles alternately.
NCT02349347 ↗ A PHASEII STUDY EVALUATING INTRAVENOUS MELPHALAN WITH AUTOLOGOUS WHOLE BLOOD STEM CELL TRANSPLANTATION (PBSCT)OVER THREE CYCLES IN PATIENTS WITH CASTRATION-RESISTANT PROSTATE CANCER (MEL-CAP). Unknown status Barts & The London NHS Trust Phase 2/Phase 3 2013-01-01 The management of (castration-resistant) prostate cancer (CRPC) is becoming increasingly complex. The use of peripheral anti-androgens with gonadorelin analogues (maximum androgen blockade) is common place. Following the failure of such an approach, several strategies may be employed. Both corticosteroids and estrogens have a role and increasingly chemotherapy is being used. The demonstration of enhanced survival using 3 weekly docetaxel has meant that this is viewed by many as the standard of care for fit patients. Melphalan is an established alkylating drug that has demonstrated some activity in CRPC, but to date, myelosuppression has prevented adequate dosing. We have recently conducted a phase I dose escalation study using melphalan and whole blood stem cell re-infusion and it shows that median overall survival is 22 months, which is higher than the median survival rate of 19 months for Docetaxel Data from a previous phase I study has proved the successful administration of higher doses of IV Melphalan in combination with autologous blood infusion in patients with Castration-resistant prostate cancer. Rapid falls in circulating tumour cells were seen within 2 weeks of starting Melphalan, however slow platelet recovery meant longer periods of platelet transfusion. For this study we intend to assess the efficacy of an intensified intravenous melphalan with autologous whole blood stem cell transplantation over three treatment cycles. 39 patients will be enrolled over a 3 year period and at least 17 patients need to survive progression free at least 6-months for this study to be considered positive. Mel-CAP is a combination chemotherapy consisting of two chemotherapy drugs: MELPHALAN and LENOGRASTIM for 3 cycles alternately.
NCT02349347 ↗ A PHASEII STUDY EVALUATING INTRAVENOUS MELPHALAN WITH AUTOLOGOUS WHOLE BLOOD STEM CELL TRANSPLANTATION (PBSCT)OVER THREE CYCLES IN PATIENTS WITH CASTRATION-RESISTANT PROSTATE CANCER (MEL-CAP). Unknown status Queen Mary University of London Phase 2/Phase 3 2013-01-01 The management of (castration-resistant) prostate cancer (CRPC) is becoming increasingly complex. The use of peripheral anti-androgens with gonadorelin analogues (maximum androgen blockade) is common place. Following the failure of such an approach, several strategies may be employed. Both corticosteroids and estrogens have a role and increasingly chemotherapy is being used. The demonstration of enhanced survival using 3 weekly docetaxel has meant that this is viewed by many as the standard of care for fit patients. Melphalan is an established alkylating drug that has demonstrated some activity in CRPC, but to date, myelosuppression has prevented adequate dosing. We have recently conducted a phase I dose escalation study using melphalan and whole blood stem cell re-infusion and it shows that median overall survival is 22 months, which is higher than the median survival rate of 19 months for Docetaxel Data from a previous phase I study has proved the successful administration of higher doses of IV Melphalan in combination with autologous blood infusion in patients with Castration-resistant prostate cancer. Rapid falls in circulating tumour cells were seen within 2 weeks of starting Melphalan, however slow platelet recovery meant longer periods of platelet transfusion. For this study we intend to assess the efficacy of an intensified intravenous melphalan with autologous whole blood stem cell transplantation over three treatment cycles. 39 patients will be enrolled over a 3 year period and at least 17 patients need to survive progression free at least 6-months for this study to be considered positive. Mel-CAP is a combination chemotherapy consisting of two chemotherapy drugs: MELPHALAN and LENOGRASTIM for 3 cycles alternately.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Gonadorelin Hydrochloride

Condition Name

Condition Name for Gonadorelin Hydrochloride
Intervention Trials
Sleep Restriction 2
Castrate Resistant Prostate Cancer 2
Hypogonadotropic Hypogonadism 2
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Condition MeSH

Condition MeSH for Gonadorelin Hydrochloride
Intervention Trials
Prostatic Neoplasms 3
Hypogonadism 2
Syndrome 1
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Clinical Trial Locations for Gonadorelin Hydrochloride

Trials by Country

Trials by Country for Gonadorelin Hydrochloride
Location Trials
United States 22
China 3
United Kingdom 2
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Trials by US State

Trials by US State for Gonadorelin Hydrochloride
Location Trials
California 3
Wisconsin 1
West Virginia 1
South Carolina 1
Pennsylvania 1
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Clinical Trial Progress for Gonadorelin Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Gonadorelin Hydrochloride
Clinical Trial Phase Trials
Phase 4 1
Phase 2/Phase 3 2
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Gonadorelin Hydrochloride
Clinical Trial Phase Trials
Unknown status 3
Recruiting 2
Active, not recruiting 2
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Clinical Trial Sponsors for Gonadorelin Hydrochloride

Sponsor Name

Sponsor Name for Gonadorelin Hydrochloride
Sponsor Trials
Los Angeles Biomedical Research Institute 2
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center 2
Barts & The London NHS Trust 2
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Sponsor Type

Sponsor Type for Gonadorelin Hydrochloride
Sponsor Trials
Other 11
NIH 1
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