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Last Updated: June 30, 2022

CLINICAL TRIALS PROFILE FOR GLYCEROL PHENYLBUTYRATE


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All Clinical Trials for Glycerol Phenylbutyrate

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01257737 ↗ To Evaluate the Safety of Long-term Use of HPN-100 in the Management of Urea Cycle Disorders (UCDs) Completed Horizon Therapeutics, LLC Phase 4 2010-10-04 This was an open-label, long-term safety study of HPN-100 (RAVICTI; glycerol phenylbutyrate) in participants with a urea cycle disorder (UCD) who completed the safety extensions of HPN-100-005 (NCT00947544; HPN-100-005SE), HPN-100-006 (NCT00947297; HPN-100-007), or HPN-100-012 (NCT01347073; HPN-100-012SE). The initial studies were 1- to 2-week crossover studies, and their associated safety extensions were 12-month, open-label studies. All participants who completed the initial studies were eligible to enroll in the associated safety extension studies, and new participants were also permitted to enroll directly into the safety extension studies.
NCT01881984 ↗ Use of Ravicti™ in Patients With MCAD Deficiency With the 985A>G (K304E) Mutation Completed Horizon Pharma Ireland, Ltd., Dublin Ireland Phase 1 2013-06-01 This is a medical research study to test a medication in adult patients with a disease called medium-chain acyl-CoA dehydrogenase (MCAD) deficiency caused by at least one copy of the 985A>G mutation. The medication is glycerol phenylbutyrate, called Ravicti, which is currently FDA approved for the treatment of urea cycle disorders. Previous research suggests that Ravicti may also be effective in the treatment MCAD deficiency. This study will investigate the safety and efficacy (how well it works) of Ravicti in patients with MCAD deficiency caused by having at least one copy of the 985A>G mutation.
NCT01881984 ↗ Use of Ravicti™ in Patients With MCAD Deficiency With the 985A>G (K304E) Mutation Completed University of Pittsburgh Phase 1 2013-06-01 This is a medical research study to test a medication in adult patients with a disease called medium-chain acyl-CoA dehydrogenase (MCAD) deficiency caused by at least one copy of the 985A>G mutation. The medication is glycerol phenylbutyrate, called Ravicti, which is currently FDA approved for the treatment of urea cycle disorders. Previous research suggests that Ravicti may also be effective in the treatment MCAD deficiency. This study will investigate the safety and efficacy (how well it works) of Ravicti in patients with MCAD deficiency caused by having at least one copy of the 985A>G mutation.
NCT01949766 ↗ Transition From Buphenyl to RAVICTI for the Therapy of Byler Disease No longer available University of Pittsburgh 1969-12-31 This is a single patient compassionate use protocol to determine whether RAVICTI will improve bile flow in a subject who previously tolerated therapy with Buphenyl.
NCT02046434 ↗ Phenylbutyrate Response as a Biomarker for Alpha-synuclein Clearance From the Brain Active, not recruiting University of Colorado, Denver Phase 1 2014-01-01 This is a Phase I clinical trial of the FDA approved drug Glycerol Phenylbutyrate to see if phenylbutyrate can increase the removal of alpha-synuclein from the brain into the bloodstream. Alpha-synuclein forms abnormal protein deposits in dopamine neurons and is believed to cause the death of brain cells, leading to Parkinson's Disease.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Glycerol Phenylbutyrate

Condition Name

Condition Name for Glycerol Phenylbutyrate
Intervention Trials
Urea Cycle Disorder 2
Achromatopsia 1
ACHROMATOPSIA 7 1
Byler Disease 1
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Condition MeSH

Condition MeSH for Glycerol Phenylbutyrate
Intervention Trials
Urea Cycle Disorders, Inborn 3
Disease 3
Brain Diseases 1
Color Vision Defects 1
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Clinical Trial Locations for Glycerol Phenylbutyrate

Trials by Country

Trials by Country for Glycerol Phenylbutyrate
Location Trials
United States 42
Spain 3
Italy 2
Canada 2
Israel 1
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Trials by US State

Trials by US State for Glycerol Phenylbutyrate
Location Trials
New York 5
Pennsylvania 5
Colorado 4
Ohio 3
Utah 3
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Clinical Trial Progress for Glycerol Phenylbutyrate

Clinical Trial Phase

Clinical Trial Phase for Glycerol Phenylbutyrate
Clinical Trial Phase Trials
Phase 4 3
Phase 2/Phase 3 1
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Glycerol Phenylbutyrate
Clinical Trial Phase Trials
Recruiting 4
Completed 3
No longer available 1
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Clinical Trial Sponsors for Glycerol Phenylbutyrate

Sponsor Name

Sponsor Name for Glycerol Phenylbutyrate
Sponsor Trials
Horizon Therapeutics, LLC 3
Horizon Pharma Ireland, Ltd., Dublin Ireland 2
University of Pittsburgh 2
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Sponsor Type

Sponsor Type for Glycerol Phenylbutyrate
Sponsor Trials
Other 12
Industry 5
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Medtronic
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