An Investigational Drug in Patients With Type 2 Diabetes Mellitus and Chronic Renal Insufficiency (0431-028)(COMPLETED)
Merck Sharp & Dohme Corp.
The purpose of this study is to determine the safety and tolerability of an investigational
drug in patients with Type 2 Diabetes Mellitus (a specific type of diabetes) and Chronic
Renal Insufficiency (inadequate kidney function).
- To investigate the efficacy of insulin glargine (in terms of change in A1c from baseline
to endpoint A1c < 7%)
- To investigate the safety of insulin glargine (in terms of hypoglycaemia, including
symptomatic, non-symptomatic and nocturnal hypoglycaemia)
- To investigate whether beta cell function is preserved if this therapy is initiated
before 2nd OAD (oral anti-diabetic drug) failure
A clinical study to determine the safety and efficacy of sitagliptin in patients with Type 2
Diabetes Mellitus who have inadequate glycemic control on metformin/peroxisome
proliferator-activated receptor gamma (PPARg) agonist combination therapy.
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