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Last Updated: May 31, 2020

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CLINICAL TRIALS PROFILE FOR GENGRAF

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All Clinical Trials for Gengraf

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00057954 Reduced-Intensity Regimen Before Allogeneic Transplant for Patients With Relapsed Non-Hodgkin's or Hodgkin's Lymphoma Terminated National Cancer Institute (NCI) Phase 2 2005-06-01 RATIONALE: Photopheresis allows patient white blood cells to be treated with ultraviolet (UV) light and drugs outside the body to inactivate T cells. Pentostatin may suppress the immune system and reduce the chance of developing graft-versus-host disease (GVHD) following bone marrow transplantation. Combining photopheresis with pentostatin and total-body irradiation may be effective in killing cancer cells before bone marrow transplantation. PURPOSE: This phase II trial is studying how well giving photophoresis together with pentostatin and total-body irradiation as a reduced-intensity regimen before allogeneic bone marrow transplantation works in treating patients with relapsed non-Hodgkin's or Hodgkin's lymphoma.
NCT00057954 Reduced-Intensity Regimen Before Allogeneic Transplant for Patients With Relapsed Non-Hodgkin's or Hodgkin's Lymphoma Terminated Eastern Cooperative Oncology Group Phase 2 2005-06-01 RATIONALE: Photopheresis allows patient white blood cells to be treated with ultraviolet (UV) light and drugs outside the body to inactivate T cells. Pentostatin may suppress the immune system and reduce the chance of developing graft-versus-host disease (GVHD) following bone marrow transplantation. Combining photopheresis with pentostatin and total-body irradiation may be effective in killing cancer cells before bone marrow transplantation. PURPOSE: This phase II trial is studying how well giving photophoresis together with pentostatin and total-body irradiation as a reduced-intensity regimen before allogeneic bone marrow transplantation works in treating patients with relapsed non-Hodgkin's or Hodgkin's lymphoma.
NCT00983424 Cyclosporine A in Combination With Nab-Paclitaxel in Patients With Metastatic Breast Cancer Completed Avon Foundation Phase 1 2010-02-01 The purpose of this research study is to evaluate the safety of therapy with nab-paclitaxel and CsA and if the addition of Cyclosporine A (CsA) to nab-paclitaxel helps stop cancer cells as well as or better than nab-paclitaxel alone.
NCT00983424 Cyclosporine A in Combination With Nab-Paclitaxel in Patients With Metastatic Breast Cancer Completed Northwestern University Phase 1 2010-02-01 The purpose of this research study is to evaluate the safety of therapy with nab-paclitaxel and CsA and if the addition of Cyclosporine A (CsA) to nab-paclitaxel helps stop cancer cells as well as or better than nab-paclitaxel alone.
NCT01106833 Chronic Graft-versus-Host Disease Treatment (BMT CTN 0801) Active, not recruiting Blood and Marrow Transplant Clinical Trials Network Phase 2/Phase 3 2010-04-01 This study is designed as a combined Phase II/III, randomized, open label, multicenter, prospective comparative study of sirolimus plus prednisone versus sirolimus/calcineurin-inhibitor plus prednisone for the treatment of chronic GVHD. Patients will be stratified by transplant center and will be randomized to an experimental arm of one of the two pre-specified experimental arms (sirolimus + prednisone or the comparator arm of sirolimus + calcineurin inhibitor + prednisone) in a 1:1 ratio.
NCT01106833 Chronic Graft-versus-Host Disease Treatment (BMT CTN 0801) Active, not recruiting National Cancer Institute (NCI) Phase 2/Phase 3 2010-04-01 This study is designed as a combined Phase II/III, randomized, open label, multicenter, prospective comparative study of sirolimus plus prednisone versus sirolimus/calcineurin-inhibitor plus prednisone for the treatment of chronic GVHD. Patients will be stratified by transplant center and will be randomized to an experimental arm of one of the two pre-specified experimental arms (sirolimus + prednisone or the comparator arm of sirolimus + calcineurin inhibitor + prednisone) in a 1:1 ratio.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Gengraf

Condition Name

Condition Name for Gengraf
Intervention Trials
Recurrent Hodgkin Lymphoma 3
Myelodysplastic Syndrome 3
Chronic Myelomonocytic Leukemia 3
Acute Lymphoblastic Leukemia 2
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Condition MeSH

Condition MeSH for Gengraf
Intervention Trials
Leukemia 5
Myelodysplastic Syndromes 5
Lymphoma 5
Preleukemia 4
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Clinical Trial Locations for Gengraf

Trials by Country

Trials by Country for Gengraf
Location Trials
United States 36
Malaysia 1
China 1
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Trials by US State

Trials by US State for Gengraf
Location Trials
Washington 6
California 2
Illinois 2
Ohio 2
New Jersey 2
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Clinical Trial Progress for Gengraf

Clinical Trial Phase

Clinical Trial Phase for Gengraf
Clinical Trial Phase Trials
Phase 4 1
Phase 2/Phase 3 1
Phase 2 6
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Clinical Trial Status

Clinical Trial Status for Gengraf
Clinical Trial Phase Trials
Not yet recruiting 5
Recruiting 3
Completed 2
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Clinical Trial Sponsors for Gengraf

Sponsor Name

Sponsor Name for Gengraf
Sponsor Trials
National Cancer Institute (NCI) 8
Fred Hutchinson Cancer Research Center 5
Northwestern University 1
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Sponsor Type

Sponsor Type for Gengraf
Sponsor Trials
Other 17
NIH 9
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