The proposed project will utilize perfusion functional magnetic resonance imaging (fMRI), a
functional candidate gene association approach (of dopaminergic addictions-targeted
polymorphisms), and the dopamine-modulating and gamma-aminobutyric acid (GABA) B receptor
agonist, baclofen, to examine the brain and behavioral responses in smokers to appetitive
smoking reminders (cues that motivate continued smoking and relapse). These studies will
provide a means to identify an appetitive cue-sensitive pharmacologic-responsive
endophenotype. Once brain/behavioral/genetic endophenotypes can be determined prior to
treatment, smoking cessation treatments can be structured to meet individual needs, which
will significantly improve treatment outcome.
The proposed project will utilize perfusion functional magnetic resonance imaging (fMRI), a
functional candidate gene association approach (of dopaminergic addictions-targeted
polymorphisms), and the dopamine-modulating and gamma-aminobutyric acid (GABA) B receptor
agonist, baclofen, to examine the brain and behavioral responses in smokers to appetitive
smoking reminders (cues that motivate continued smoking and relapse). These studies will
provide a means to identify an appetitive cue-sensitive pharmacologic-responsive
endophenotype. Once brain/behavioral/genetic endophenotypes can be determined prior to
treatment, smoking cessation treatments can be structured to meet individual needs, which
will significantly improve treatment outcome.
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