Evaluation of Fosaprepitant (MK0517) in Single Dose Schedule (0517-017)
Completed
Merck Sharp & Dohme Corp.
Phase 3
2008-02-01
The purpose of this study is to examine the safety, tolerability, and efficacy of MK0517 to
prevent Chemotherapy-Induced Nausea and Vomiting (CINV) associated with Cisplatin
chemotherapy.
A Study of MK-0869 (Aprepitant) and MK-0517 (Fosaprepitant) in Pediatric Participants Receiving Chemotherapy (MK-0869-134)
Terminated
Merck Sharp & Dohme Corp.
Phase 1
2009-02-05
This study will determine the appropriate dosing regimen of aprepitant and fosaprepitant for
the prevention of chemotherapy-induced nausea and vomiting in pediatric participants from 0
months to 17 years of age.
Fosaprepitant Dimeglumine, Palonosetron Hydrochloride, and Dexamethasone in Preventing Nausea and Vomiting Caused by Cisplatin in Patients With Stage III or Stage IV Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy
Terminated
National Cancer Institute (NCI)
Phase 2
2009-02-01
RATIONALE: Fosaprepitant dimeglumine, palonosetron hydrochloride, and dexamethasone may help
lessen or prevent nausea and vomiting caused by cisplatin in patients with head and neck
cancer undergoing chemotherapy and radiation therapy.
PURPOSE: This phase II trial is studying how well fosaprepitant dimeglumine together with
palonosetron hydrochloride and dexamethasone works in preventing nausea and vomiting caused
by cisplatin in patients with stage III or stage IV head and neck cancer undergoing
chemotherapy and radiation therapy.
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