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Generated: June 16, 2019

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CLINICAL TRIALS PROFILE FOR FLUOROMETHOLONE

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Clinical Trials for Fluorometholone

Trial ID Title Status Sponsor Phase Summary
NCT00707421 Usefulness of Topical Non-Steroidal Anti-Inflammatory Drugs or Steroids Before Trabeculectomy and Clinical Outcomes Completed Funding for Research in Ophthalmology (FRO) Phase 3 Antiglaucoma medication have been shown to induce subclinical conjunctival inflammation in a considerable proportion of glaucoma patients. Today, trabeculectomy still remains the gold standard as surgical treatment of medically uncontrolled glaucoma disease. However, this procedure is associated with variable possible complications, of which subconjunctival fibrosis is the most frequent one. The latter results in a non-functional filtering bleb. As a consequence, either additional interventions such as laser suture lysis, needling, bleb revision or additional IOP-lowering medication is necessary. Previous studies demonstrated a benefit of the use of topical steroids postoperatively in reducing inflammation and subsequent subconjunctival fibrosis. In this perspective, we will prospectively explore the usefulness of topical NSAID or corticosteroid therapy preoperatively as compared to placebo in subjects scheduled for first-time trabeculectomy, without interrupting topical antiglaucoma therapy. This will allow us to determine wether the impact of longterm topical antiglaucoma therapy on subclinical conjunctival inflammation which possibly result in postoperative fibrosis and bleb failure can be reversed by anti-inflammatory medication before filtering surgery.
NCT00707421 Usefulness of Topical Non-Steroidal Anti-Inflammatory Drugs or Steroids Before Trabeculectomy and Clinical Outcomes Completed Universitaire Ziekenhuizen Leuven Phase 3 Antiglaucoma medication have been shown to induce subclinical conjunctival inflammation in a considerable proportion of glaucoma patients. Today, trabeculectomy still remains the gold standard as surgical treatment of medically uncontrolled glaucoma disease. However, this procedure is associated with variable possible complications, of which subconjunctival fibrosis is the most frequent one. The latter results in a non-functional filtering bleb. As a consequence, either additional interventions such as laser suture lysis, needling, bleb revision or additional IOP-lowering medication is necessary. Previous studies demonstrated a benefit of the use of topical steroids postoperatively in reducing inflammation and subsequent subconjunctival fibrosis. In this perspective, we will prospectively explore the usefulness of topical NSAID or corticosteroid therapy preoperatively as compared to placebo in subjects scheduled for first-time trabeculectomy, without interrupting topical antiglaucoma therapy. This will allow us to determine wether the impact of longterm topical antiglaucoma therapy on subclinical conjunctival inflammation which possibly result in postoperative fibrosis and bleb failure can be reversed by anti-inflammatory medication before filtering surgery.
NCT00824811 Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel Withdrawn Allergan Phase 2 Objective: To evaluate the safety and efficacy of topical cyclosporine eye drops (Restasis®) for the treatment of epiphora caused by canalicular stenosis secondary to Docetaxel (Taxotere®) treatment for various cancers.
NCT00824811 Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel Withdrawn M.D. Anderson Cancer Center Phase 2 Objective: To evaluate the safety and efficacy of topical cyclosporine eye drops (Restasis®) for the treatment of epiphora caused by canalicular stenosis secondary to Docetaxel (Taxotere®) treatment for various cancers.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Fluorometholone

Condition Name

Condition Name for Fluorometholone
Intervention Trials
Intraocular Pressure 3
Trabeculectomy 1
Dry Eye Syndromes 1
Pupil Centroid Shift 1
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Condition MeSH

Condition MeSH for Fluorometholone
Intervention Trials
Keratoconjunctivitis Sicca 3
Dry Eye Syndromes 3
Eye Diseases 2
Macular Edema 1
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Clinical Trial Locations for Fluorometholone

Trials by Country

Trials by Country for Fluorometholone
Location Trials
United States 2
China 2
Egypt 1
Belgium 1
Spain 1
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Trials by US State

Trials by US State for Fluorometholone
Location Trials
Utah 1
Indiana 1
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Clinical Trial Progress for Fluorometholone

Clinical Trial Phase

Clinical Trial Phase for Fluorometholone
Clinical Trial Phase Trials
Phase 4 4
Phase 3 2
Phase 2 4
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Clinical Trial Status

Clinical Trial Status for Fluorometholone
Clinical Trial Phase Trials
Completed 7
Recruiting 3
Not yet recruiting 1
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Clinical Trial Sponsors for Fluorometholone

Sponsor Name

Sponsor Name for Fluorometholone
Sponsor Trials
Dr Salouti Eye Research Center 1
Universitaire Ziekenhuizen Leuven 1
Berhan Public Health and Eye Care Consultancy PLC 1
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Sponsor Type

Sponsor Type for Fluorometholone
Sponsor Trials
Other 17
Industry 2
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