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Last Updated: December 14, 2024

CLINICAL TRIALS PROFILE FOR FISH OIL; MEDIUM CHAIN TRIGLYCERIDES; OLIVE OIL; SOYBEAN OIL


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All Clinical Trials for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00600912 ↗ Influence of of a Lipid Emulsion on Inflammatory Response and Hepatic Function Completed Klinikum Ludwigshafen Phase 4 2006-12-01 Lipid emulsions are an essential part of parenteral nutrition, both as a part of energy supply, and as a source of essential fatty acids. It has been shown that the fatty acid composition of cell membranes is influenced by the fatty acid profile of dietary lipids, and may therefore be responsible for modulation of immune response. The aim of this study was to assess the effects of a new lipid emulsion based ob soybean oil, medium-chain triglycerides, olive oil and fish oil compared with a lipid emulsion based on olive and soybean oil on the inflammatory response and hepatic function in postoperative intensive care unit (ICU) patients.
NCT02412566 ↗ SMOF Lipid for Children With Parenteral Nutrition Induced Liver Injury Available Fresenius Kabi 1969-12-31 While fish-oil lipid emulsions have shown a benefit to the treatment of parenteral nutrition (PN)-associated cholestasis, the dose is limited to 1 g/kg/day. Similarly, in early PN-associated cholestasis the dose of soy-based lipid is limited to 1 g/kg/day. Often the calories that are lost from this relative decreased dose of lipids can be provided by adjusting the dextrose content of the PN solution and providing a higher glucose infusion rate. In some cases, this is not tolerated or even with maximizing this strategy, growth is inadequate. Inadequate growth is a direct cause of poor outcomes including poorer neurological outcome, failure to be able to stop mechanical ventilation and poorer growth of their often already damaged intestine. These outcomes can lead to severe disability and death. Therefore, infants receiving only 1 g/kg/day of lipids who are not adequately growing must have a greater intake of lipids to meet their needs for weight, length, and head circumference growth. SMOFlipid (Fresenius Kabi, Bad Homburg, Germany) contains a mixture of 4 different lipid sources: soybean oil providing essential fatty acids, olive oil rich in monounsaturated fatty acids which are less susceptible to lipid peroxidation than polyunsaturated fatty acids, medium-chain triglycerides showing a faster metabolic clearance than long-chain triglycerides, and fish oil for the supply of omega-3 fatty acids. It is safe to give in what is the usual dose for lipid therapy in neonates of 3 g/kg/day, rather than being limited to 1 g/kg/day as we do with cholestatic infants receiving Omegaven or soy lipids. Because this product includes both omega-6 and omega-3 lipids, it provides the benefits of the omega-3s for the liver and provides more than enough omega-6s to meet essential fatty acid requirements. Its use in situations in which growth is inadequate in babies who must be restricted to 1 g/kg/day can be expected to improve their growth and likely markedly increase their chances of both a good neurological outcome and survival. Purpose: We want to find out if this new intravenous fat mixture (SMOFlipid) will help promote good growth while reducing the severity (or seriousness) of liver disease or help put an end to liver disease in infants.
NCT02412566 ↗ SMOF Lipid for Children With Parenteral Nutrition Induced Liver Injury Available Baylor College of Medicine 1969-12-31 While fish-oil lipid emulsions have shown a benefit to the treatment of parenteral nutrition (PN)-associated cholestasis, the dose is limited to 1 g/kg/day. Similarly, in early PN-associated cholestasis the dose of soy-based lipid is limited to 1 g/kg/day. Often the calories that are lost from this relative decreased dose of lipids can be provided by adjusting the dextrose content of the PN solution and providing a higher glucose infusion rate. In some cases, this is not tolerated or even with maximizing this strategy, growth is inadequate. Inadequate growth is a direct cause of poor outcomes including poorer neurological outcome, failure to be able to stop mechanical ventilation and poorer growth of their often already damaged intestine. These outcomes can lead to severe disability and death. Therefore, infants receiving only 1 g/kg/day of lipids who are not adequately growing must have a greater intake of lipids to meet their needs for weight, length, and head circumference growth. SMOFlipid (Fresenius Kabi, Bad Homburg, Germany) contains a mixture of 4 different lipid sources: soybean oil providing essential fatty acids, olive oil rich in monounsaturated fatty acids which are less susceptible to lipid peroxidation than polyunsaturated fatty acids, medium-chain triglycerides showing a faster metabolic clearance than long-chain triglycerides, and fish oil for the supply of omega-3 fatty acids. It is safe to give in what is the usual dose for lipid therapy in neonates of 3 g/kg/day, rather than being limited to 1 g/kg/day as we do with cholestatic infants receiving Omegaven or soy lipids. Because this product includes both omega-6 and omega-3 lipids, it provides the benefits of the omega-3s for the liver and provides more than enough omega-6s to meet essential fatty acid requirements. Its use in situations in which growth is inadequate in babies who must be restricted to 1 g/kg/day can be expected to improve their growth and likely markedly increase their chances of both a good neurological outcome and survival. Purpose: We want to find out if this new intravenous fat mixture (SMOFlipid) will help promote good growth while reducing the severity (or seriousness) of liver disease or help put an end to liver disease in infants.
NCT02663453 ↗ Effectiveness of Multicomponent Lipid Emulsion in Preterm Infants Requiring Parenteral Nutrition Completed Thammasat University Phase 3 2013-12-01 The purpose of this study is to compare the effects of a multicomponent lipid emulsion containing 30% soybean oil, 30% medium-chain triglycerides, 25% olive oil, and 15% fish oil with a conventional pure soybean oil lipid emulsion on the incidence of neonatal cholestasis, infant growth, infant morbidity and the biochemical assessment of liver enzymes.
NCT02721277 ↗ SMOFlipid to Lessen the Severity of Neonatal Cholestasis Terminated University of Florida Phase 1/Phase 2 2016-05-01 Parenteral nutrition (PN) provides intravenous nutritional supplementation for infants unable to absorb adequate enteral nutrients secondary to insufficient intestinal length or function. In early PN-associated cholestasis, the dose of traditional soy based lipid is limited to 1 g/kg/day which often limits the growth capacity of parenteral nutrition-dependent infants. Inadequate growth is directly related to poor neurological outcomes, failure to facilitate mechanical ventilation, and less growth of the neonate's already damaged intestine. Ultimately, these outcomes can lead to severe disability and death. To mitigate these deleterious effects and optimize growth, parenteral nutrition-dependent infants with cholestasis who are not adequately growing on 1 g/kg/day of soy-based lipid emulsion must have a greater intake of lipids to meet their needs for weight, length, and head circumference growth. SMOFlipid contains a mixture of 4 different lipid sources: soybean oil which provides essential fatty acids, olive oil which is high in monounsaturated fatty acids that are less susceptible to lipid peroxidation than polyunsaturated fatty acids, medium-chain triglycerides which show a faster metabolic clearance than long-chain triglycerides, and fish oil which provides the supply of omega-3 fatty acids. The utility of Omegaven and soy-based lipid emulsion is limited as these are restricted to 1 g/kg/day in cholestatic infants. SMOFlipid is safe to be provided at the usual goal infusion amount of 3 g/kg/day. Because this product includes both omega-6 and omega-3 lipids, it provides the benefits of the omega-3s for the liver and provides more than enough omega-6s to meet essential fatty acid requirements. Its use in situations in which growth is inadequate in babies who must be restricted to 1 g/kg/day can be expected to improve their growth and likely markedly increase their chances of both a good neurological outcome and survival. The aim of this research study is to determine if the unique formulation of SMOFLipid will cause less hepatic inflammation compared to soy only intralipids.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil

Condition Name

Condition Name for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil
Intervention Trials
Cholestasis 3
Injection Site Irritation 1
Ischemic Reperfusion Injury 1
Jaundice, Obstructive 1
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Condition MeSH

Condition MeSH for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil
Intervention Trials
Cholestasis 3
Neonatal Sepsis 1
Jaundice, Obstructive 1
Short Bowel Syndrome 1
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Clinical Trial Locations for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil

Trials by Country

Trials by Country for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil
Location Trials
United States 3
Egypt 2
Germany 1
Saudi Arabia 1
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Trials by US State

Trials by US State for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil
Location Trials
Minnesota 1
Florida 1
Texas 1
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Clinical Trial Progress for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil

Clinical Trial Phase

Clinical Trial Phase for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil
Clinical Trial Phase Trials
Phase 4 3
Phase 3 2
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil
Clinical Trial Phase Trials
Completed 5
Available 1
Unknown status 1
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Clinical Trial Sponsors for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil

Sponsor Name

Sponsor Name for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil
Sponsor Trials
Carola Pfeiffer-Mosesson 1
Mansoura University 1
Mayo Clinic 1
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Sponsor Type

Sponsor Type for Fish Oil; Medium Chain Triglycerides; Olive Oil; Soybean Oil
Sponsor Trials
Other 10
Industry 1
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