Does Dapagliflozin Augment The Favorable Adaptation To Endurance Exercise Training?
Completed
AstraZeneca
Phase 2
2015-06-01
Exercise is frequently prescribed as a favorable lifestyle intervention to prevent/reverse
type 2 diabetes. It is also prescribed in addition to concurrent pharmacological treatment,
such as metformin. Recent data (animal and human) suggest that metformin may attenuate the
favorable benefits of exercise training. In light of the physiological mechanism of
Dapagliflozin (sodium-glucose co-transporter 2 (SGLT2) inhibition), one might speculate that
rather than inhibit, it will augment the favorable adaptations to exercise training.
Does Dapagliflozin Augment The Favorable Adaptation To Endurance Exercise Training?
Completed
Christopher Bell
Phase 2
2015-06-01
Exercise is frequently prescribed as a favorable lifestyle intervention to prevent/reverse
type 2 diabetes. It is also prescribed in addition to concurrent pharmacological treatment,
such as metformin. Recent data (animal and human) suggest that metformin may attenuate the
favorable benefits of exercise training. In light of the physiological mechanism of
Dapagliflozin (sodium-glucose co-transporter 2 (SGLT2) inhibition), one might speculate that
rather than inhibit, it will augment the favorable adaptations to exercise training.
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