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Serving hundreds of leading biopharmaceutical companies globally:

US Army
Chubb
Argus Health
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Queensland Health
US Department of Justice
Accenture
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Generated: December 10, 2018

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CLINICAL TRIALS PROFILE FOR ERIVEDGE

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Clinical Trials for Erivedge

Trial ID Title Status Sponsor Phase Summary
NCT00636610 A Study of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) With Concurrent Chemotherapy and Bevacizumab As First-Line Therapy for Metastatic Colorectal Cancer Completed Genentech, Inc. Phase 2 This was a randomized, placebo-controlled, double-blind study of vismodegib (GDC-0449) added to biochemotherapy standard-of-care regimens for metastatic colorectal cancer (CRC), with treatment until disease progression. Patients received either FOLFOX (FOL=leucovorin calcium [folinic acid], F=fluorouracil, OX=oxaliplatin) or FOLFIRI (FOL=leucovorin calcium [folinic acid] F=fluorouracil, IRI=irinotecan hydrochloride) chemotherapy with bevacizumab. The decision of which regimen (FOLFOX or FOLFIRI) to use was made by the treating physician and patient. Patients were randomized to receive vismodegib or placebo and were stratified based on the chemotherapy regimen chosen and whether or not Response Evaluation Criteria in Solid Tumors (RECIST) measurable disease was present at baseline.
NCT00822458 GDC-0449 in Treating Young Patients With Medulloblastoma That is Recurrent or Did Not Respond to Previous Treatment Completed National Cancer Institute (NCI) Phase 1 This phase I trial is studying the side effects and best dose of GDC-0449 in treating young patients with medulloblastoma that is recurrent or did not respond to previous treatment. GDC-0449 may be effective in treating young patients with medulloblastoma.
NCT00878163 GDC-0449 and Erlotinib Hydrochloride With or Without Gemcitabine Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer or Solid Tumors That Cannot Be Removed by Surgery Active, not recruiting National Cancer Institute (NCI) Phase 1 This phase I trial is studying the side effects and best dose of erlotinib hydrochloride when given together with GDC-0449 with or without gemcitabine hydrochloride in treating patients with metastatic pancreatic cancer or solid tumors that cannot be removed by surgery. Drugs used in chemotherapy, such as GDC-0449 and gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving GDC-0449 together with erlotinib hydrochloride with or without gemcitabine hydrochloride may kill more tumor cells.
NCT00887159 A Randomized Phase II Study of Cisplatin and Etoposide in Combination With Either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients With Extensive Stage Active, not recruiting National Cancer Institute (NCI) Phase 2 This randomized phase II trial studies cisplatin and etoposide to see how well they work when given with or without Hedgehog inhibitor GDC-0449 (vismodegib) or IGF-1R MOAB IMC-A12 (cixutumumab) in treating patients with extensive-stage small cell lung cancer. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Etoposide may slow the growth of tumor cells by blocking some of the enzymes needed for cell growth. Vismodegib may slow the growth of tumor cells. Monoclonal antibodies, such as cixutumumab, may interfere with the ability of tumor cells to grow and spread. It is not yet known whether giving cisplatin and etoposide are more effective when given together with vismodegib or cixutumumab in treating small cell lung cancer.
NCT00939484 Vismodegib in Treating Patients With Recurrent or Refractory Medulloblastoma Completed National Cancer Institute (NCI) Phase 2 This phase II trial is studying how well vismodegib works in treating adult patients with recurrent or refractory medulloblastoma. Vismodegib may slow the growth of tumor cells and may be an effective treatment for medulloblastoma.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Erivedge

Condition Name

Condition Name for Erivedge
Intervention Trials
Basal Cell Carcinoma 6
Locally Advanced Basal Cell Carcinoma 3
Stage IV Pancreatic Cancer 3
Recurrent Childhood Medulloblastoma 2
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Condition MeSH

Condition MeSH for Erivedge
Intervention Trials
Carcinoma 16
Carcinoma, Basal Cell 14
Adenocarcinoma 4
Neoplasms 4
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Clinical Trial Locations for Erivedge

Trials by Country

Trials by Country for Erivedge
Location Trials
United States 199
Germany 5
Canada 4
Italy 4
Netherlands 2
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Trials by US State

Trials by US State for Erivedge
Location Trials
California 14
Michigan 12
New York 11
Pennsylvania 10
Illinois 10
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Clinical Trial Progress for Erivedge

Clinical Trial Phase

Clinical Trial Phase for Erivedge
Clinical Trial Phase Trials
Phase 4 1
Phase 2 23
Phase 1/Phase 2 6
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Clinical Trial Status

Clinical Trial Status for Erivedge
Clinical Trial Phase Trials
Recruiting 14
Completed 13
Active, not recruiting 8
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Clinical Trial Sponsors for Erivedge

Sponsor Name

Sponsor Name for Erivedge
Sponsor Trials
National Cancer Institute (NCI) 19
Genentech, Inc. 10
Hoffmann-La Roche 3
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Sponsor Type

Sponsor Type for Erivedge
Sponsor Trials
Industry 26
Other 21
NIH 19
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Serving hundreds of leading biopharmaceutical companies globally:

Mallinckrodt
US Department of Justice
Fish and Richardson
Boehringer Ingelheim
Queensland Health
Accenture
Dow
AstraZeneca
Argus Health

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