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Generated: December 13, 2018

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CLINICAL TRIALS PROFILE FOR EPINEPHRINE

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Clinical Trials for Epinephrine

Trial ID Title Status Sponsor Phase Summary
NCT00000290 Stress Hormones and Human Cocaine Use - 7 Completed University of Minnesota - Clinical and Translational Science Institute Phase 1 The purpose of this study is to determine the HPA axis and adrenergic system activation in response to cocaine administration.
NCT00000290 Stress Hormones and Human Cocaine Use - 7 Completed National Institute on Drug Abuse (NIDA) Phase 1 The purpose of this study is to determine the HPA axis and adrenergic system activation in response to cocaine administration.
NCT00001724 Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction Completed National Institute of Dental and Craniofacial Research (NIDCR) Phase 2 This study will evaluate the effectiveness of the non-steroidal anti-inflammatory drug flurbiprofen (Ansaid® (Registered Trademark)) in relieving pain following oral surgery. Flurbiprofen is approved by the Food and Drug Administration for treatment of arthritis pain. Patients 16 years of age and older requiring third molar (wisdom tooth) extraction may be eligible for this study. Patients will undergo oral surgery to remove two lower third molar teeth. Before surgery, they will be given a local anesthetic (lidocaine with epinephrine) injected in the mouth and a sedative (Versed) infused through a catheter (thin plastic tube) placed in an arm vein. At the time of surgery, patients will also be given flurbiprofen or a placebo formulation (look-alike substance with no active ingredient) directly into the extraction site and a capsule that also may contain flurbiprofen or placebo. One in seven patients will receive only placebo. All patients will fill out pain questionnaires and stay in the clinic for up to 6 hours for observation of bleeding and medication side effects. Patients who do not have satisfactory pain relief from the test medicine after surgery may request a standard pain reliever. A small blood sample will be collected during surgery and at 15 minutes, one-half hour and 1, 2, 3, 4, 5, 6, 24 and 48 hours after surgery to measure flurbiprofen blood levels. A total of 33 ml (about 2 tablespoons) of blood will be drawn for these tests. Samples collected on the day of surgery will be drawn from the catheter used to administer the sedative; the 24- and 48-hour samples will be taken by needle from an arm or hand vein. Urine samples will also be collected between 4 and 6 hours after surgery and again at 24 and 48 hours after surgery.
NCT00002659 Cisplatin Plus Epinephrine in Treating Patients With Recurrent or Refractory Head and Neck Cancer Unknown status Matrix Pharmaceutical Phase 3 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known if treatment with cisplatin plus epinephrine is effective for head and neck cancer. PURPOSE: Randomized double-blinded phase III trial to determine the effectiveness of cisplatin plus epinephrine in injectable gel form in treating patients who have recurrent or refractory head and neck cancer.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Epinephrine

Condition Name

Condition Name for Epinephrine
Intervention Trials
Pain 35
Postoperative Pain 22
Bronchiolitis 15
Pain, Postoperative 13
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Condition MeSH

Condition MeSH for Epinephrine
Intervention Trials
Pain, Postoperative 43
Bronchiolitis 20
Heart Arrest 14
Pulpitis 14
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Clinical Trial Locations for Epinephrine

Trials by Country

Trials by Country for Epinephrine
Location Trials
United States 260
Canada 30
Korea, Republic of 22
Brazil 16
Egypt 15
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Trials by US State

Trials by US State for Epinephrine
Location Trials
California 29
New York 20
Maryland 18
Texas 17
Pennsylvania 16
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Clinical Trial Progress for Epinephrine

Clinical Trial Phase

Clinical Trial Phase for Epinephrine
Clinical Trial Phase Trials
Phase 4 138
Phase 3 35
Phase 2/Phase 3 17
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Clinical Trial Status

Clinical Trial Status for Epinephrine
Clinical Trial Phase Trials
Completed 186
Recruiting 95
Not yet recruiting 59
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Clinical Trial Sponsors for Epinephrine

Sponsor Name

Sponsor Name for Epinephrine
Sponsor Trials
University of Minnesota - Clinical and Translational Science Institute 9
University of North Carolina, Chapel Hill 7
Amphastar Pharmaceuticals, Inc. 7
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Sponsor Type

Sponsor Type for Epinephrine
Sponsor Trials
Other 530
Industry 56
NIH 15
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Serving hundreds of leading biopharmaceutical companies globally:

US Department of Justice
Fuji
Daiichi Sankyo
McKinsey
Mallinckrodt
Johnson and Johnson
Express Scripts
US Army
Merck

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