Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old
Vanderbilt University Medical Center
Pseudohypoparathyroidism is a genetic disorder with limited treatment options, characterized
by early-onset obesity, short stature and resistance to multiple hormones. This phase 2
clinical trial and open-label extension study will test the efficacy of theophylline, a
phosphodiesterase inhibitor, in pseudohypoparathyroidism. We hypothesize that theophylline
will cause weight loss, slow the rate of growth plate closure and decrease hormone resistance
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