Comparison of Gadovist 75% Standard Dose to Dotarem at Full Standard Dose
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The study is being conducted to gain knowledge about a new dose of a diagnostic drug that is
used for contrast-enhanced Magnetic Resonance Imaging (MRI) of the human central nervous
system (CNS). MRI can visualize the anatomy of the body and is used to detect medical
conditions. Diagnostic drugs like gadobutrol and gadoterate contain an element called
gadolinium that is applied to improve the analysability of MRI-images.
The purpose of this study is to examine if contrast-enhanced MRI using a reduced dose of the
gadolinium-based contrast agent gadobutrol delivers images of similar quality to those
obtained when a full dose of the gadolinium-based contrast agent gadoterate is used.
Renal Safety Evaluation After Dotarem®-Enhanced MRI
Although there is a well documented risk of acute renal failure with the iodinated contrast
agents, the implication of intravenous gadolinium-based contrast agents in nephrotoxicity
remains controversial. The aim of this study was to evaluate the safety profile of
gadoterate meglumine (Dotarem®) in patients with chronic renal insufficiency by evaluating
the rate of patients experiencing contrast-induced nephrotoxicity following the injection of
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