Comparison of Gadovist 75% Standard Dose to Dotarem at Full Standard Dose
Completed
Bayer
Phase 4
2018-11-14
The study was conducted to gain knowledge about a new dose of a diagnostic drug that is used
for contrast-enhanced Magnetic Resonance Imaging (MRI) of the human central nervous system
(CNS). MRI can visualize the anatomy of the body and is used to detect medical conditions.
Diagnostic drugs like gadobutrol and gadoterate contain an element called gadolinium that is
applied to improve the analysability of MRI-images.
The purpose of this study was to examine if contrast-enhanced MRI using a reduced dose of the
gadolinium-based contrast agent gadobutrol delivers images of similar quality to those
obtained when a full dose of the gadolinium-based contrast agent gadoterate was used.
Renal Safety Evaluation After Dotarem®-Enhanced MRI
Completed
Guerbet
Phase 4
2008-01-01
Although there is a well documented risk of acute renal failure with the iodinated contrast
agents, the implication of intravenous gadolinium-based contrast agents in nephrotoxicity
remains controversial. The aim of this study was to evaluate the safety profile of gadoterate
meglumine (Dotarem®) in patients with chronic renal insufficiency by evaluating the rate of
patients experiencing contrast-induced nephrotoxicity following the injection of gadoterate
meglumine.
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