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Generated: March 20, 2019

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CLINICAL TRIALS PROFILE FOR DONEPEZIL HYDROCHLORIDE; MEMANTINE HYDROCHLORIDE

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Clinical Trials for Donepezil Hydrochloride; Memantine Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00154635 Efficacy and Safety Study of DCB-AD1 in Patients With Mild to Moderate Alzheimer’s Disease Unknown status Development Center for Biotechnology, Taiwan Phase 2 A Double-blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of DCB-AD1 in Patients with Mild to Moderate Alzheimer’s Disease. Because of the limitation of the sample size we could expect but a positive trend of the efficacy unless the effect size of DCB-AD1 is larger than 0.63. This information will provide us clue if further clinical investigation such as a phase III study should be carried out in an even larger scale. We also should be able to obtain valuable experience on the adverse effect of prolonged (24-week) use of Fo-ti.
NCT00154635 Efficacy and Safety Study of DCB-AD1 in Patients With Mild to Moderate Alzheimer’s Disease Unknown status Program Office, National Science & Technology, Biotechnology & Pharmaceuticals Phase 2 A Double-blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of DCB-AD1 in Patients with Mild to Moderate Alzheimer’s Disease. Because of the limitation of the sample size we could expect but a positive trend of the efficacy unless the effect size of DCB-AD1 is larger than 0.63. This information will provide us clue if further clinical investigation such as a phase III study should be carried out in an even larger scale. We also should be able to obtain valuable experience on the adverse effect of prolonged (24-week) use of Fo-ti.
NCT00154635 Efficacy and Safety Study of DCB-AD1 in Patients With Mild to Moderate Alzheimer’s Disease Unknown status Taipei Veterans General Hospital, Taiwan Phase 2 A Double-blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of DCB-AD1 in Patients with Mild to Moderate Alzheimer’s Disease. Because of the limitation of the sample size we could expect but a positive trend of the efficacy unless the effect size of DCB-AD1 is larger than 0.63. This information will provide us clue if further clinical investigation such as a phase III study should be carried out in an even larger scale. We also should be able to obtain valuable experience on the adverse effect of prolonged (24-week) use of Fo-ti.
NCT00154635 Efficacy and Safety Study of DCB-AD1 in Patients With Mild to Moderate Alzheimer’s Disease Unknown status National Taiwan University Hospital Phase 2 A Double-blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of DCB-AD1 in Patients with Mild to Moderate Alzheimer’s Disease. Because of the limitation of the sample size we could expect but a positive trend of the efficacy unless the effect size of DCB-AD1 is larger than 0.63. This information will provide us clue if further clinical investigation such as a phase III study should be carried out in an even larger scale. We also should be able to obtain valuable experience on the adverse effect of prolonged (24-week) use of Fo-ti.
NCT00181298 Memantine in Systemic Lupus Erythematosus Completed Forest Laboratories N/A Neuropsychiatric manifestations of Systemic Lupus Erythematosus (NPSLE) are both common and an important source of morbidity. Of the case definitions for NPSLE syndromes that have recently been developed, cognitive dysfunction appears to be the most prevalent. A novel mechanism is that a subset of SLE patients with cognitive dysfunction have antibodies in the NR2 glutamate receptor. We propose, in a double -blind placebo-controlled trial, to determine whether SLE patients, with or without the NR2 glutamate receptor antibody, have significant improvement using memantine, an inhibitor of the NMDA receptor.
NCT00181298 Memantine in Systemic Lupus Erythematosus Completed Johns Hopkins University N/A Neuropsychiatric manifestations of Systemic Lupus Erythematosus (NPSLE) are both common and an important source of morbidity. Of the case definitions for NPSLE syndromes that have recently been developed, cognitive dysfunction appears to be the most prevalent. A novel mechanism is that a subset of SLE patients with cognitive dysfunction have antibodies in the NR2 glutamate receptor. We propose, in a double -blind placebo-controlled trial, to determine whether SLE patients, with or without the NR2 glutamate receptor antibody, have significant improvement using memantine, an inhibitor of the NMDA receptor.
NCT00234637 Rivastigmine Monotherapy and Combination Therapy With Memantine in Patients With Moderately Severe Alzheimer's Disease Who Failed to Benefit From Previous Cholinesterase Inhibitor Treatment Completed Novartis Phase 4 This is a prospective, multicenter, open-label study. Following screening and baseline assessments, eligible patients will be switched to rivastigmine and will enter the 16 week run-in rivastigmine treatment phase. After completion of assessments at the end of the run-in phase, patients who were not sufficiently stabilized on rivastigmine alone will receive add-on memantine to their rivastigmine treatment; patients who were stabilized on rivastigmine alone will have completed and be discontinued from the study.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Donepezil Hydrochloride; Memantine Hydrochloride

Condition Name

Condition Name for Donepezil Hydrochloride; Memantine Hydrochloride
Intervention Trials
Alzheimer's Disease 10
Dementia, Alzheimer Type 2
Dementia 2
Alzheimer Disease 2
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Condition MeSH

Condition MeSH for Donepezil Hydrochloride; Memantine Hydrochloride
Intervention Trials
Alzheimer Disease 16
Dementia 4
Cognition Disorders 1
Multiple Sclerosis, Relapsing-Remitting 1
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Clinical Trial Locations for Donepezil Hydrochloride; Memantine Hydrochloride

Trials by Country

Trials by Country for Donepezil Hydrochloride; Memantine Hydrochloride
Location Trials
United States 78
Spain 5
Canada 5
France 4
United Kingdom 4
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Trials by US State

Trials by US State for Donepezil Hydrochloride; Memantine Hydrochloride
Location Trials
California 5
New York 5
North Carolina 5
Florida 5
Georgia 4
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Clinical Trial Progress for Donepezil Hydrochloride; Memantine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Donepezil Hydrochloride; Memantine Hydrochloride
Clinical Trial Phase Trials
Phase 4 8
Phase 3 4
Phase 2 3
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Clinical Trial Status

Clinical Trial Status for Donepezil Hydrochloride; Memantine Hydrochloride
Clinical Trial Phase Trials
Completed 10
Unknown status 5
Not yet recruiting 2
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Clinical Trial Sponsors for Donepezil Hydrochloride; Memantine Hydrochloride

Sponsor Name

Sponsor Name for Donepezil Hydrochloride; Memantine Hydrochloride
Sponsor Trials
Forest Laboratories 4
Johns Hopkins University 2
American Academy of Neurology 1
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Sponsor Type

Sponsor Type for Donepezil Hydrochloride; Memantine Hydrochloride
Sponsor Trials
Other 22
Industry 14
NIH 1
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