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Mallinckrodt
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Generated: September 20, 2018

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CLINICAL TRIALS PROFILE FOR DONEPEZIL HYDROCHLORIDE

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Clinical Trials for Donepezil Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00000173 Memory Impairment Study (Mild Cognitive Impairment Study) Completed Alzheimer's Disease Cooperative Study (ADCS) Phase 3 The National Institute on Aging (NIA) is launching a nationwide treatment study targeting individuals with mild cognitive impairment (MCI), a condition characterized by a memory deficit, but not dementia. An NIA-funded study recently confirmed that MCI is different from both dementia and normal age-related changes in memory. Accurate and early evaluation and treatment of MCI individuals might prevent further cognitive decline, including development of Alzheimer's disease (AD). The Memory Impairment Study is the first such AD prevention clinical trial carried out by NIH, and will be conducted at 65-80 medical research institutions located in the United States and Canada. This study will test the usefulness of two drugs to slow or stop the conversion from MCI to AD. The trial will evaluate placebo, vitamin E, and donepezil, an investigational agent approved by the Food and Drug Administration for another use. Vitamin E (alpha-tocopherol) is thought to have antioxidant properties, and was shown in a 1997 study to delay important dementia milestones, such as patients' institutionalization or progression to severe dementia, by about seven months.
NCT00000173 Memory Impairment Study (Mild Cognitive Impairment Study) Completed National Institute on Aging (NIA) Phase 3 The National Institute on Aging (NIA) is launching a nationwide treatment study targeting individuals with mild cognitive impairment (MCI), a condition characterized by a memory deficit, but not dementia. An NIA-funded study recently confirmed that MCI is different from both dementia and normal age-related changes in memory. Accurate and early evaluation and treatment of MCI individuals might prevent further cognitive decline, including development of Alzheimer's disease (AD). The Memory Impairment Study is the first such AD prevention clinical trial carried out by NIH, and will be conducted at 65-80 medical research institutions located in the United States and Canada. This study will test the usefulness of two drugs to slow or stop the conversion from MCI to AD. The trial will evaluate placebo, vitamin E, and donepezil, an investigational agent approved by the Food and Drug Administration for another use. Vitamin E (alpha-tocopherol) is thought to have antioxidant properties, and was shown in a 1997 study to delay important dementia milestones, such as patients' institutionalization or progression to severe dementia, by about seven months.
NCT00004807 Study of the Pathogenesis of Rett Syndrome Completed Johns Hopkins University N/A OBJECTIVES: I. Extend current knowledge of the phenotype and natural history of Rett syndrome (RS). II. Continue the search for a cytogenetic and/or DNA marker. III. Study the effects of cholinergic drugs based on preliminary evidence for reduced levels of brain acetylcholine, while continuing supportive care to modify seizures, respiratory abnormalities, and motor disturbances, and improve nutrition, behavior, and learning. IV. Identify targets for future therapeutic interventions, e.g., growth factors, to influence neurologic recovery.
NCT00004807 Study of the Pathogenesis of Rett Syndrome Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) N/A OBJECTIVES: I. Extend current knowledge of the phenotype and natural history of Rett syndrome (RS). II. Continue the search for a cytogenetic and/or DNA marker. III. Study the effects of cholinergic drugs based on preliminary evidence for reduced levels of brain acetylcholine, while continuing supportive care to modify seizures, respiratory abnormalities, and motor disturbances, and improve nutrition, behavior, and learning. IV. Identify targets for future therapeutic interventions, e.g., growth factors, to influence neurologic recovery.
NCT00006349 Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer Completed National Cancer Institute (NCI) Phase 3 RATIONALE: Donepezil and vitamin E may be able to decrease side effects caused by radiation therapy given to prevent brain metastases in patients with small cell lung cancer. It is not yet known if donepezil and vitamin E are effective in preventing side effects caused by radiation therapy to the head. PURPOSE: Randomized phase III trial to determine the effectiveness of donepezil and vitamin E in preventing side effects caused by radiation therapy given to prevent brain metastases in patients who have small cell lung cancer.
NCT00006349 Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer Completed Alliance for Clinical Trials in Oncology Phase 3 RATIONALE: Donepezil and vitamin E may be able to decrease side effects caused by radiation therapy given to prevent brain metastases in patients with small cell lung cancer. It is not yet known if donepezil and vitamin E are effective in preventing side effects caused by radiation therapy to the head. PURPOSE: Randomized phase III trial to determine the effectiveness of donepezil and vitamin E in preventing side effects caused by radiation therapy given to prevent brain metastases in patients who have small cell lung cancer.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Donepezil Hydrochloride

Condition Name

Condition Name for Donepezil Hydrochloride
Intervention Trials
Alzheimer's Disease 81
Alzheimer Disease 31
Healthy 20
Dementia 16
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Condition MeSH

Condition MeSH for Donepezil Hydrochloride
Intervention Trials
Alzheimer Disease 137
Dementia 47
Cognition Disorders 27
Mild Cognitive Impairment 12
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Clinical Trial Locations for Donepezil Hydrochloride

Trials by Country

Trials by Country for Donepezil Hydrochloride
Location Trials
United States 682
Japan 167
Canada 83
Germany 64
Korea, Republic of 45
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Trials by US State

Trials by US State for Donepezil Hydrochloride
Location Trials
California 49
Florida 44
New York 42
Texas 36
Arizona 32
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Clinical Trial Progress for Donepezil Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Donepezil Hydrochloride
Clinical Trial Phase Trials
Phase 4 68
Phase 3 45
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Donepezil Hydrochloride
Clinical Trial Phase Trials
Completed 160
Recruiting 36
Terminated 27
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Clinical Trial Sponsors for Donepezil Hydrochloride

Sponsor Name

Sponsor Name for Donepezil Hydrochloride
Sponsor Trials
Pfizer 31
Eisai Inc. 24
Eisai Co., Ltd. 11
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Sponsor Type

Sponsor Type for Donepezil Hydrochloride
Sponsor Trials
Industry 192
Other 175
NIH 34
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Serving hundreds of leading biopharmaceutical companies globally:

Chubb
Federal Trade Commission
Medtronic
Citi
Deloitte
Farmers Insurance
Queensland Health
Covington
Baxter

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