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Last Updated: February 24, 2021

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CLINICAL TRIALS PROFILE FOR DIFFERIN

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505(b)(2) Clinical Trials for Differin

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
New Formulation NCT03615768 A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris Recruiting Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Limited Phase 3 2018-08-14 This is a study to see if Adapalene-Clindamycin Combination Gel is effective and safe in the treatment of acne vulgaris, compared to adapalene gel alone and clindamycin gel alone. Adapalene and clindamycin have been reported to have a better effect in acne treatment when used together. This new formulation is also easier to use as it combines two products into a single gel and only needs to be used once a day.
New Formulation NCT03615768 A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris Recruiting Lee's Pharmaceutical Limited Phase 3 2018-08-14 This is a study to see if Adapalene-Clindamycin Combination Gel is effective and safe in the treatment of acne vulgaris, compared to adapalene gel alone and clindamycin gel alone. Adapalene and clindamycin have been reported to have a better effect in acne treatment when used together. This new formulation is also easier to use as it combines two products into a single gel and only needs to be used once a day.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Differin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00160394 Comparison of Duac® Gel And Differin® Gel in Mild to Moderate Acne Vulgaris Completed GlaxoSmithKline Phase 4 2004-12-01 Comparing the efficacy and safety of a gel formulation containing a combination of clindamycin phosphate (equivalent to 1% clindamycin) and benzoyl peroxide (5%) once daily with a gel containing 0.1% adapalene once daily in the treatment of acne vulgaris of mild to moderate severity.
NCT00160394 Comparison of Duac® Gel And Differin® Gel in Mild to Moderate Acne Vulgaris Completed Stiefel, a GSK Company Phase 4 2004-12-01 Comparing the efficacy and safety of a gel formulation containing a combination of clindamycin phosphate (equivalent to 1% clindamycin) and benzoyl peroxide (5%) once daily with a gel containing 0.1% adapalene once daily in the treatment of acne vulgaris of mild to moderate severity.
NCT00237978 Control of Therapy of Acne Papulopustulosa by Visible Light With Waterfiltered Infrared and / or Adapalen (Differin Gel) Unknown status Technische Universität Dresden Phase 4 2006-09-01 The aim of the study is to investigate the effectivity of visible light in combination with waterfiltered infrared in treating acne papulopustulosa. The reduction of inflammatory and non-inflammatory lesions within 8 weeks will be measured and compared with the standard treatment with Adapalene.
NCT00469755 Differin® Gel x12 Wks vs Tazorac® Cream x12 Wks vs Differin® x6 Wks Switched to Tazorac® x6 Wks for Treatment of Acne Completed Galderma Laboratories, L.P. Phase 4 2006-02-01 To determine the efficacy and safety of 12 weeks of treatment with Differin Gel, 0.1% compared to 12 weeks of treatment with Tazorac Cream, 0.1% and compared to 6 weeks treatment with Differin Gel, 0.1% followed by 6 weeks of treatment with Tazorac Cream
NCT00647556 Adapalene Gel 0.3% Versus Tretinoin 0.05% Emollient Cream for Treatment of Photodamage Completed Galderma Laboratories, L.P. Phase 3 2008-04-01 The primary purpose of this study is to compare the efficacy of adapalene (Differin®) gel 0.3% and tretinoin 0.05% emollient cream for the treatment of signs of photodamage, with tolerability assessment as a secondary objective.
NCT00660985 Pharmacokinetic Study to Compare the Systemic Exposure of Differin® Gel, 0.3% or Differin® Gel, 0.1% Completed Galderma Phase 4 2008-05-01 Phase 4 commitment pharmacokinetic study to determine systemic exposure to adapalene.
NCT00671749 Combination Therapy With Differin® Gel 0.3% and Duac® (Clindamycin/Benzoyl Peroxide Gel) in Subjects With Acne Vulgaris Completed Galderma Laboratories, L.P. Phase 4 2007-12-01 This study is to determine the efficacy and safety of 12 week treatment with Differin® Gel 0.3% applied in the evening, in combination with Duac® (Clindamycin/Benzoyl Peroxide Gel) applied in the morning, in Subjects with Acne vulgaris.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Differin

Condition Name

Condition Name for Differin
Intervention Trials
Acne Vulgaris 15
Skin Manifestations 2
Photoaging 1
Healthy Skin 1
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Condition MeSH

Condition MeSH for Differin
Intervention Trials
Acne Vulgaris 15
Skin Manifestations 2
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Clinical Trial Locations for Differin

Trials by Country

Trials by Country for Differin
Location Trials
United States 40
Belize 2
Germany 2
Spain 1
Poland 1
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Trials by US State

Trials by US State for Differin
Location Trials
Texas 5
California 4
Ohio 3
Michigan 3
Florida 3
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Clinical Trial Progress for Differin

Clinical Trial Phase

Clinical Trial Phase for Differin
Clinical Trial Phase Trials
Phase 4 10
Phase 3 4
Phase 1 5
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Clinical Trial Status

Clinical Trial Status for Differin
Clinical Trial Phase Trials
Completed 14
Recruiting 2
Unknown status 2
[disabled in preview] 2
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Clinical Trial Sponsors for Differin

Sponsor Name

Sponsor Name for Differin
Sponsor Trials
Galderma Laboratories, L.P. 5
Allergan 2
Stiefel, a GSK Company 2
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Sponsor Type

Sponsor Type for Differin
Sponsor Trials
Industry 20
Other 5
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