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Generated: December 10, 2018

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CLINICAL TRIALS PROFILE FOR DEXTROSE 4% IN MODIFIED LACTATED RINGER'S IN PLASTIC CONTAINER

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Clinical Trials for Dextrose 4% In Modified Lactated Ringer's In Plastic Container

Trial ID Title Status Sponsor Phase Summary
NCT01022151 Aminophylline and Cognitive Function After Sevoflurane Anaesthesia Completed King Faisal University Phase 2 Early postoperative recovery of neurologic and cognitive functions is especially advantageous after fast-tracking ambulatory procedures to hasten home discharge after surgery.1 It is well known that volatile anaesthetic agents may generate adverse postoperative cognitive effects and even traces of it may affect task performance in healthy volunteers.2Hence, rapid elimination of the volatile anaesthetics may help reduce postoperative confusion and cognitive impairment in surgical patients by facilitating a faster recovery from general anaesthesia.3 Sevoflurane has been advocated for the routine anesthesia for ambulatory surgery patients. It activates adenosine A1 receptors in primary rat hippocampal cultures through the liberation of adenosine secondary to the interaction of with adenosine transport or key enzymes in adenosine metabolism.4 However; sevoflurane anaesthesia is associated with slower emergence and delayed early postoperative cognitive recovery than desflurane5 and xenon2 anaesthesia. Aminophylline, which is a hydrophilic cyclic adenosine mono-phosphate (cAMP) dependent phosphodiesterase inhibitor has been used for long time to antagonize the sedative effects of morphine, diazepam, and barbiturates.6-7Aminophylline in doses of 2-5 mg/kg shortens the recovery from sevoflurane anaesthesia and improves bispectral index scores (BIS) with concurrent increases in heart rate which might have a detrimental effect in patients with ischaemic heart disease.8-11However, the use of smaller doses of 2-3 mg/kg is associated with less increases in heart rate. 10-11 The use of 1 mg/kg of Doxapram is comparable to 2 mg/kg of aminophylline in improvement of early recovery from sevoflurane anaesthesia secondary to its central nervous system stimulating effect rather than increased ventilatory elimination of sevoflurane.11 Currently, there is no available published studies have investigated the effects of either theophylline or doxapram on early postoperative cognitive recovery after balanced anaesthesia with sevoflurane. We hypothesized that the use of small doses of aminophylline [2-3 mg/kg] may be comparable to larger doses in improvement of the early postoperative cognitive recovery from sevoflurane anaesthesia with associated non-significant increases in heart rate. The present study investigated the effects of 1 mg/kg of doxapram, and 2, 3, 4, and 5 mg/kg of aminophylline on the early postoperative cognitive recovery using the Short Orientation Memory Concentration Test (SOMCT), response entropy (RE) state entropy (SE), difference between RE and SE (RE-SE), end-tidal sevoflurane concentration, haemodynamics, the times to eyes opening and to extubation and degree of sedation after sevoflurane anaesthesia in patients undergoing ambulatory surgery.
NCT01337739 Use of Dexmedetomidine for Deep Sedation in Patients Undergoing Outpatient Hysteroscopic Surgery Terminated Northwestern University N/A Patients undergoing deep sedation for outpatient procedures typically receive a combination of benzodiazepines, propofol, and opioids. Side effects of such anesthetics include respiratory depression, nausea and vomiting, and urinary retention, with resultant extended hospital stays and unanticipated admission. The use of dexmedetomidine for deep sedation may increase patient safety by maintaining respiratory drive, while providing sedation, hypnosis, and analgesia. Furthermore, patients may experience decreased pain, nausea, and time to discharge in the PACU, especially if dexmedetomidine decreases the requirement of other drugs such as opioids. The hypothesis of this study is administration of dexmedetomidine during deep sedation for ambulatory hysteroscopic surgery will result in a 50% reduction of intraoperative opioid compared to sedation with propofol.
NCT01431612 Effects of Adrenergic Drugs on the Fluid Balance During Surgery Completed Zhejiang University Phase 1/Phase 2 The aim this study was to examine to what degree the slow turnover of lactated Ringer's solution during anesthesia and surgery can be prevented by infusing esmolol (a ß1-receptor blocker) or phenylephrine in patients undergoing laparoscopic gynecological surgery performed under intravenous anesthesia.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Dextrose 4% In Modified Lactated Ringer's In Plastic Container

Condition Name

Condition Name for Dextrose 4% In Modified Lactated Ringer's In Plastic Container
Intervention Trials
Elective Open Thoracotomy 1
Post-operative Pain for Total Knee Arthroplasty 1
Cryptorchidism 1
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Condition MeSH

Condition MeSH for Dextrose 4% In Modified Lactated Ringer's In Plastic Container
Intervention Trials
Pain, Postoperative 2
Hypotension 1
Hernia, Inguinal 1
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Clinical Trial Locations for Dextrose 4% In Modified Lactated Ringer's In Plastic Container

Trials by Country

Trials by Country for Dextrose 4% In Modified Lactated Ringer's In Plastic Container
Location Trials
Saudi Arabia 2
China 1
Egypt 1
United States 1
Canada 1
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Trials by US State

Trials by US State for Dextrose 4% In Modified Lactated Ringer's In Plastic Container
Location Trials
Illinois 1
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Clinical Trial Progress for Dextrose 4% In Modified Lactated Ringer's In Plastic Container

Clinical Trial Phase

Clinical Trial Phase for Dextrose 4% In Modified Lactated Ringer's In Plastic Container
Clinical Trial Phase Trials
Phase 4 1
Phase 3 1
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Dextrose 4% In Modified Lactated Ringer's In Plastic Container
Clinical Trial Phase Trials
Completed 6
Recruiting 1
Terminated 1
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Clinical Trial Sponsors for Dextrose 4% In Modified Lactated Ringer's In Plastic Container

Sponsor Name

Sponsor Name for Dextrose 4% In Modified Lactated Ringer's In Plastic Container
Sponsor Trials
Mustafa Kemal University 1
Dammam University 1
Sodertalje Hospital 1
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Sponsor Type

Sponsor Type for Dextrose 4% In Modified Lactated Ringer's In Plastic Container
Sponsor Trials
Other 10
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Serving hundreds of leading biopharmaceutical companies globally:

Mallinckrodt
Fish and Richardson
US Army
Daiichi Sankyo
Covington
Citi
Harvard Business School
Moodys
Deloitte

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