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Generated: December 17, 2018

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CLINICAL TRIALS PROFILE FOR DEXAMETHASONE SODIUM PHOSPHATE

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Clinical Trials for Dexamethasone Sodium Phosphate

Trial ID Title Status Sponsor Phase Summary
NCT00122278 Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines Completed Montefiore Medical Center Phase 3 Migraines are a specific type of headache that frequently recur and are very painful. Although there are many medications that are effective against migraines, none of these medications cure 100% of migraines. Another problem with migraines is that although many times they get better after intravenous (IV) treatment in the emergency room (ER), about 1/3 of the time migraines recur the next day. The purpose of this research project is to see if adding a medication called dexamethasone to standard ER therapy will help patients get better quicker and stay pain-free more often than if they receive placebo.
NCT00266838 Prevention of Docetaxel Induced Dacryostenosis Completed Universitaire Ziekenhuizen Leuven Phase 1 The antineoplastic agent Docetaxel (Taxotere®) is approved for the treatment of patients with metastatic and locally advanced breast cancer and other malignancies. There are 2 frequently used schedules of treatment with Docetaxel. Docetaxel can be administered every 3 weeks or in a weekly regimen. The efficacy seems to be similar but the toxicity profile changes. In the standard 3-weekly Docetaxel regimen the dose-limiting side effect is myelosuppression, while in the weekly regimen there is only a mild myelosuppression. On the other hand, weekly Docetaxel has a side effect that is rare in the 3-weekly schedule: epiphora (= tearing eye) caused by dacryostenosis. The underlying mechanism of dacryostenosis induced by weekly Docetaxel is fibrosis of the lacrimal puncta and canaliculi. Docetaxel has been reported to be secreted in the lacrimal tears. Direct contact between Docetaxel containing tears and the epithelial lining causes chronic inflammation of the mucosa and ultimately fibrosis of the most narrow part of the lacrimal outflow system i.e. the lacrimal puncta and canaliculi. A surgical treatment is possible for dacryostenosis. In case of subtotal stenosis of the lacrimal canaliculi, silicone intubation of the canaliculi is performed in order to prevent further closure. In the case of complete stenosis, placement of a permanent pyrex glass tube of Jones is required. To our knowledge, there is no primary prevention for Docetaxel induced dacryostenosis. The rationale of this randomized double blind interventional study is to investigate the efficacy of corticosteroid versus artificial tears topical eye treatment in patients on a weekly Docetaxel regimen in prevention of dacryostenosis. The dacryotoxic agent Docetaxel in the lacrimal tears will be washed away by the repetitive use of eye drops. In addition, eye drops containing corticosteroids have an anti-inflammatory effect and may further prevent the formation of fibrosis. A new treatment protocol will be investigated. Two different commercially available eye drops will be compared: dexamethasone sodium phosphate (Maxidex®, Alcon) in one eye of the patient and artificial tears (Lacrystat®, Viatris) in the other eye of the same patient. The study period will start with topical eye treatment from day 1 of cycle 1 and will continue during the administration of chemotherapy, with a final analysis at 26 weeks.
NCT01129856 Safety and Efficacy Study of EGP-437 (Dexamethasone Phosphate Formulated for Ocular Iontophoresis) to Treat Dry Eye Completed Eyegate Pharmaceuticals, Inc. Phase 3 The purpose of this study is to assess the safety and efficacy of EGP-437 (dexamethasone phosphate formulated for ocular iontophoresis) using the EyeGate® II Iontophoresis system in patients with dry eye.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Dexamethasone Sodium Phosphate

Condition Name

Condition Name for Dexamethasone Sodium Phosphate
Intervention Trials
Postoperative Pain 4
Healthy 2
Pain, Postoperative 1
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Condition MeSH

Condition MeSH for Dexamethasone Sodium Phosphate
Intervention Trials
Pain, Postoperative 5
Uveitis 2
Retinal Vein Occlusion 2
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Clinical Trial Locations for Dexamethasone Sodium Phosphate

Trials by Country

Trials by Country for Dexamethasone Sodium Phosphate
Location Trials
United States 62
Finland 2
Egypt 2
Germany 1
Brazil 1
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Trials by US State

Trials by US State for Dexamethasone Sodium Phosphate
Location Trials
New York 5
Massachusetts 4
North Carolina 3
Colorado 3
Tennessee 3
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Clinical Trial Progress for Dexamethasone Sodium Phosphate

Clinical Trial Phase

Clinical Trial Phase for Dexamethasone Sodium Phosphate
Clinical Trial Phase Trials
Phase 4 8
Phase 3 6
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Dexamethasone Sodium Phosphate
Clinical Trial Phase Trials
Not yet recruiting 11
Recruiting 10
Completed 9
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Clinical Trial Sponsors for Dexamethasone Sodium Phosphate

Sponsor Name

Sponsor Name for Dexamethasone Sodium Phosphate
Sponsor Trials
Erydel 4
Eyegate Pharmaceuticals, Inc. 2
Tampere University Hospital 2
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Sponsor Type

Sponsor Type for Dexamethasone Sodium Phosphate
Sponsor Trials
Other 21
Industry 12
NIH 1
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