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CLINICAL TRIALS PROFILE FOR DEFINITY

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Clinical Trials for Definity

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00162058	A Phase II Study of DMP 115 to Assess Focal Liver Lesions	Completed	Lantheus Medical Imaging	Phase 2	To determine the optimal dose of DMP 115 to image liver lesions and to assess whether contrast can improve the detection of focal liver lesions.
NCT00162370	A Study of Stress Echocardiography in Post-Menopausal Women at Risk for Coronary Disease	Completed	Lantheus Medical Imaging	Phase 4	The study is designed to see if stress echocardiography can be used as a screening exam in peri-, or post-menopausal women with a risk of developing of coronary artery disease and experiencing future cardiac events.
NCT00239525	3-D Transcranial Ultrasound Analysis Study	Completed	Duke University	N/A	The purpose of this study is to investigate real time 3-D ultrasound imaging of the brain for the diagnosis and evaluation of stroke.
NCT00401687	DMP115 in Patients With an Ejection Fraction Between 25%-40% to Evaluate the Use of Contrast Echocardiography to Assess Heart Function	Completed	Lantheus Medical Imaging	Phase 4	The purpose of this clinical research study is to demonstrate the ability of Definity® enhanced versus unenhanced cardiac ultrasound to improve the accuracy and reproducibility of left ventricular ejection fraction (EF) when compared to magnetic resonance imaging (MRI).
NCT00507806	Microbubble-Enhanced Clotbust Treatment of Acute Ischemic Stroke	Terminated	ImaRx Therapeutics	Phase 1/Phase 2	The study is designed to examine the safety, tolerability, and activity of a combination of microbubbles (perflutren lipid microsphere [Definity®]) and continuous monitoring with 2 MHz transcranial Doppler ultrasound (TCD) as an adjunctive therapy to tissue plasminogen activator (tPA) treatment in subjects with acute ischemic stroke.

Clinical Trial Conditions for Definity

Condition Name

Condition Name for Definity
Intervention	Trials
Breast Cancer	3
Coronary Artery Disease	3
Cardiac Disease	2
Hepatocellular Carcinoma	2

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Condition MeSH

Condition MeSH for Definity
Intervention	Trials
Heart Diseases	4
Coronary Disease	3
Carcinoma, Renal Cell	3
Coronary Artery Disease	3

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Clinical Trial Locations for Definity

Trials by Country

Trials by Country for Definity
Location	Trials
United States	63
Canada	2
United Kingdom	1

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Trials by US State

Trials by US State for Definity
Location	Trials
Pennsylvania	7
Minnesota	7
Texas	6
North Carolina	6
California	5

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Clinical Trial Progress for Definity

Clinical Trial Phase

Clinical Trial Phase for Definity
Clinical Trial Phase	Trials
Phase 4	9
Phase 3	3
Phase 2	7

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Clinical Trial Status

Clinical Trial Status for Definity
Clinical Trial Phase	Trials
Completed	14
Not yet recruiting	8
Recruiting	7

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Clinical Trial Sponsors for Definity

Sponsor Name

Sponsor Name for Definity
Sponsor	Trials
Lantheus Medical Imaging	15
University of Virginia	4
National Institutes of Health (NIH)	3

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Sponsor Type

Sponsor Type for Definity
Sponsor	Trials
Other	49
Industry	21
NIH	7

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