Clonidine as Adjunct Therapy for the Treatment of Neonatal Abstinence Syndrome
Completed
Johns Hopkins University
Phase 2
2002-07-01
To test the hypothesis that the combination of the tincture of opium (DTO) and clonidine will
be more effective in treating infants with neonatal abstinence syndrome (opioid withdrawal)
than tincture of opium (DTO) alone.
Clonidine as Adjunct Therapy for the Treatment of Neonatal Abstinence Syndrome
Completed
National Institute on Drug Abuse (NIDA)
Phase 2
2002-07-01
To test the hypothesis that the combination of the tincture of opium (DTO) and clonidine will
be more effective in treating infants with neonatal abstinence syndrome (opioid withdrawal)
than tincture of opium (DTO) alone.
Tonsillectomy is associated with a significant decrease quality of life in children secondary
to pain, which is worsened with swallowing. The objective of the current study is to conduct
a prospective, double-blind, placebo-controlled, randomized clinical trial using a
pre-tonsillectomy infiltration of the tonsillar fossa comparing three treatment regimens in
reducing post-tonsillectomy morbidity (i.e. pain, poor oral intake): 1) Placebo (saline
injection) 2) bupivacaine (0.5%) + lidocaine (1%), 3) bupivacaine (0.5%) + lidocaine (1%) +
clonidine (25 µg).
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