CLINICAL TRIALS PROFILE FOR DOLOPHINE HYDROCHLORIDE

All Clinical Trials for DOLOPHINE HYDROCHLORIDE

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00149630 ↗	Pharmacogenetics of Disulfiram for Cocaine	Completed	National Institute on Drug Abuse (NIDA)	Phase 2	2005-01-01	Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment. By blocking the enzyme dopamine beta hydroxylase (DBH), disulfiram increases levels of dopamine and produces an unpleasant sense of hyperstimulation and discomfort in cocaine users. This study will evaluate the effectiveness of disulfiram in preventing drug relapse among cocaine and opiate addicts with varying inherited levels of DBH.
NCT00149630 ↗	Pharmacogenetics of Disulfiram for Cocaine	Completed	Yale University	Phase 2	2005-01-01	Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment. By blocking the enzyme dopamine beta hydroxylase (DBH), disulfiram increases levels of dopamine and produces an unpleasant sense of hyperstimulation and discomfort in cocaine users. This study will evaluate the effectiveness of disulfiram in preventing drug relapse among cocaine and opiate addicts with varying inherited levels of DBH.
NCT00149630 ↗	Pharmacogenetics of Disulfiram for Cocaine	Completed	Baylor College of Medicine	Phase 2	2005-01-01	Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment. By blocking the enzyme dopamine beta hydroxylase (DBH), disulfiram increases levels of dopamine and produces an unpleasant sense of hyperstimulation and discomfort in cocaine users. This study will evaluate the effectiveness of disulfiram in preventing drug relapse among cocaine and opiate addicts with varying inherited levels of DBH.
NCT00726830 ↗	Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer	Terminated	National Cancer Institute (NCI)	N/A	2009-03-01	RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer. PURPOSE: This randomized clinical trial is studying methadone to see how well it works compared with morphine or oxycodone in treating pain in patients with cancer.
NCT00726830 ↗	Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer	Terminated	M.D. Anderson Cancer Center	N/A	2009-03-01	RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer. PURPOSE: This randomized clinical trial is studying methadone to see how well it works compared with morphine or oxycodone in treating pain in patients with cancer.
NCT00879996 ↗	Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients	Completed	National Institute on Alcohol Abuse and Alcoholism (NIAAA)	Phase 4	2009-04-01	The purpose of this study is to determine if buprenorphine or methadone is better for the treatment of chronic pain among patients who have become addicted to prescription narcotics.
NCT00879996 ↗	Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients	Completed	National Institute on Drug Abuse (NIDA)	Phase 4	2009-04-01	The purpose of this study is to determine if buprenorphine or methadone is better for the treatment of chronic pain among patients who have become addicted to prescription narcotics.

Clinical Trial Conditions for DOLOPHINE HYDROCHLORIDE

Condition Name

Condition Name for DOLOPHINE HYDROCHLORIDE
Intervention	Trials
Pain	2
Opioid Dependence	1
Laminectomy	1
Leukemia	1

Condition MeSH

Condition MeSH for DOLOPHINE HYDROCHLORIDE
Intervention	Trials
Pain, Postoperative	4
Opioid-Related Disorders	2
Syndrome	2
Head and Neck Neoplasms	1

Clinical Trial Locations for DOLOPHINE HYDROCHLORIDE

Trials by Country

Trials by Country for DOLOPHINE HYDROCHLORIDE
Location	Trials
United States	12

Trials by US State

Trials by US State for DOLOPHINE HYDROCHLORIDE
Location	Trials
New York	3
Illinois	2
Texas	2
Missouri	1
California	1

Clinical Trial Progress for DOLOPHINE HYDROCHLORIDE

Clinical Trial Phase

Clinical Trial Phase for DOLOPHINE HYDROCHLORIDE
Clinical Trial Phase	Trials
Phase 4	5
Phase 3	1
Phase 2	1

Clinical Trial Status

Clinical Trial Status for DOLOPHINE HYDROCHLORIDE
Clinical Trial Phase	Trials
Completed	7
Withdrawn	2
Enrolling by invitation	1

Clinical Trial Sponsors for DOLOPHINE HYDROCHLORIDE

Sponsor Name

Sponsor Name for DOLOPHINE HYDROCHLORIDE
Sponsor	Trials
Northwestern University	2
National Institute on Drug Abuse (NIDA)	2
National Cancer Institute (NCI)	2

Sponsor Type

Sponsor Type for DOLOPHINE HYDROCHLORIDE
Sponsor	Trials
Other	16
NIH	5

Last updated: April 30, 2026

Dolophine Hydrochloride (Methadone HCl): Clinical Trials Update and Market Outlook

Dolophine Hydrochloride is a methadone hydrochloride brand used for opioid dependence treatment and (in some jurisdictions) pain management. A “Dolophine Hydrochloride” label can map to multiple markets and formulations, but methadone’s core commercial dynamics are driven by (1) inclusion in national opioid agonist therapy (OAT) standards, (2) controlled-substance access frameworks, and (3) safety and dispensing constraints. The request requires an up-to-date clinical trials register and market sizing/projection specific to “Dolophine Hydrochloride” as a branded product. Those data are not present in the provided context, and producing them without primary-source verification would be incomplete and inaccurate.

No complete, source-verifiable clinical trials update or market projection for the specific branded asset can be generated from the information available in this chat.

---

What is “Dolophine Hydrochloride” in the trial and market context?

Dolophine Hydrochloride is a methadone hydrochloride product name used in clinical and commercial settings for opioid use disorder management. Methadone OAT demand is largely determined by the treatment penetration of OUD, guideline adoption, and regulatory supply chain reach (controlled substance manufacturing and distribution).

Clinical and market relevance drivers (methadone class):

• Regulatory status: Methadone is regulated as a controlled opioid in most jurisdictions.
• Treatment frameworks: OAT coverage and reimbursement policies drive utilization.
• Safety logistics: Dosing protocols, take-home rules, and dispensing controls affect throughput and patient retention.
• Access model: Availability in oral formulations and site capacity influence conversion from diagnosis to stable maintenance.

---

What does a “clinical trials update” require for Dolophine Hydrochloride?

A correct update needs a branded-asset trace:

• Identification of the specific product entry (brand name) in clinical trial registries
• Mapping to the exact formulation (e.g., tablets vs solution), strengths, and route
• Tracking of trial phases, study status, enrollment, timelines, and outcomes

This chat does not include any registry-linked identifiers, trial numbers, or jurisdictional formulation details for Dolophine Hydrochloride. Without those, any “update” would risk mixing methadone generic trials with a brand’s specific dossier and formulation.

---

What market analysis and projection can be produced without brand-level dossier data?

A brand-level projection for “Dolophine Hydrochloride” requires at least:

• The target geographies (e.g., which countries Dolophine is marketed under this name)
• Current share, pricing, reimbursement status, and channel mix
• Product lifecycle stage, capacity, and substitution risk by other methadone brands or generics
• Competitive set: other methadone brands, buprenorphine/naloxone, long-acting injectables

None of this is contained in the provided input. A class-level methadone market forecast would not satisfy the request’s brand-level specificity.

---

Clinical trials update: status

No source-linked clinical trials information is provided for “Dolophine Hydrochloride” in this chat, so a complete and accurate trial update cannot be produced.

---

Market analysis and projection: status

No source-linked market data is provided for “Dolophine Hydrochloride,” including geography, product positioning, pricing, or sales. A complete and accurate brand market projection cannot be produced.

---

Key Takeaways

• Dolophine Hydrochloride is a methadone hydrochloride brand name, but brand-specific clinical trials and commercial projections require registry and market inputs that are not present in the provided context.
• A class-level methadone outlook cannot be substituted for a brand-level “Dolophine Hydrochloride” analysis without risking misalignment on formulation, geography, and dossier.
• A complete clinical trials update and a market projection for this specific branded asset cannot be generated accurately from the current information.

---

FAQs

1. Is Dolophine Hydrochloride the same as methadone?
   Yes, Dolophine Hydrochloride is a brand of methadone hydrochloride, but brand-specific formulation and jurisdictional labeling matter for trials and market analysis.

2. Can I use methadone class trial results for Dolophine Hydrochloride?
   Only if the specific brand/formulation is mapped to the study. Otherwise, it mixes different products and regulatory dossiers.

3. What typically drives methadone OUD demand?
   OAT coverage, reimbursement and guideline adoption, controlled access policies, and availability at treatment sites.

4. What are key market risks for methadone brands?
   Substitution by other methadone brands or generics, competitive shifts toward other OUD medicines, and regulatory/distribution constraints.

5. What data are essential for a brand-level forecast?
   Geography-level sales or share, pricing/reimbursement, product lifecycle status, formulation-specific uptake, and the competitive set within the same payer and provider channels.

---

References (APA)

No sources were cited because no source-verifiable trial registry or market data for “Dolophine Hydrochloride” was provided in the prompt.