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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR DIGOXIN


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All Clinical Trials for DIGOXIN

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000476 ↗ Digitalis Investigation Group (DIG) Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1990-06-01 To determine if digitalis had a beneficial, harmful, or no effect on total mortality in patients with clinical heart failure and sinus rhythm.
NCT00000547 ↗ Enalapril After Anthracycline Cardiotoxicity Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1994-04-01 To determine if the chronic administration of enalapril, an inhibitor of angiotensin converting enzyme (ACE), reduces progression of cardiac dysfunction in pediatric oncology patients who have received anthracyclines, and who are not currently on digoxin, diuretics, or vasodilators for heart failure.
NCT00000556 ↗ Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1995-03-01 To compare two standard treatment strategies for atrial fibrillation: ventricular rate control and anticoagulation vs. rhythm control and anticoagulation.
NCT00006330 ↗ Pharmacokinetic and Pharmacodynamic Interaction Study of Digoxin and Hawthorn Completed National Center for Research Resources (NCRR) N/A 1969-12-31 Hawthorn (Crataegus oxyacantha) is a natural product that is popular in European and American herbal medicine practice. Some of its cardiac uses include the treatment of high and low blood pressure, rapid heart beat, chest pain, and blocked arteries. In many cases, it is used as an adjuvant agent with other cardiac drugs such as digoxin, amiodarone, and warfarin. To date, little information is known about the effect of hawthorn when taken with other drugs and if toxicities occur when hawthorn is used with other drugs. The purpose of this study is to examine the interaction between digoxin and hawthorn in eight healthy subjects. Subjects will be recruited by advertisement. The design of the study will include a 10-day and a three-week treatment phase of digoxin 0.125 mg - 0.25 mg/day and hawthorn (Crataegus special extract WS1442, Schwabe Co.) 450 mg twice daily or placebo, with a randomized crossover. There will be a three-week washout period in between treatment phases. On day 10 (phase I) and day 21 (phase II), subjects will have 12 blood samples drawn for pharmacokinetic analysis. The plasma samples will be measured for digoxin concentration. Additionally, the subjects will be assessed for any clinical toxicities or adverse events. The significance of this study is to provide the clinician with information regarding the safe use of digoxin in combination with the herbal supplement, hawthorn.
NCT00007605 ↗ Comparing the Effects of Amiodarone, Sotalol, and Placebo in Maintaining Sinus Rhythm in Patients With Atrial Fibrillation Converted to Sinus Rhythm Completed US Department of Veterans Affairs Phase 3 1998-04-01 Atrial fibrillation is the most frequently occurring cardiac arrhythmia, with 1.0-1.5 million cases annually. It is a risk factor for congestive heart failure, and stroke, 75,000 cases of the latter occurring annually in patients with atrial fibrillation. The safety of the most widely used antiarrhythmic agent for this group of patients, quinidine, has been called into question. This study seeks to determine whether two other agents, amiodarone and sotalol, are safe and effective treatments for patients with atrial fibrillation.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for DIGOXIN

Condition Name

Condition Name for DIGOXIN
Intervention Trials
Healthy 36
Atrial Fibrillation 16
Healthy Volunteers 13
Heart Failure 12
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Condition MeSH

Condition MeSH for DIGOXIN
Intervention Trials
Atrial Fibrillation 24
Heart Failure 22
Breast Neoplasms 5
Arthritis, Rheumatoid 5
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Clinical Trial Locations for DIGOXIN

Trials by Country

Trials by Country for DIGOXIN
Location Trials
United States 173
Germany 22
Canada 18
Japan 12
China 11
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Trials by US State

Trials by US State for DIGOXIN
Location Trials
Texas 24
Florida 13
California 12
Ohio 11
New York 10
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Clinical Trial Progress for DIGOXIN

Clinical Trial Phase

Clinical Trial Phase for DIGOXIN
Clinical Trial Phase Trials
Phase 4 25
Phase 3 18
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for DIGOXIN
Clinical Trial Phase Trials
Completed 135
Not yet recruiting 26
Recruiting 24
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Clinical Trial Sponsors for DIGOXIN

Sponsor Name

Sponsor Name for DIGOXIN
Sponsor Trials
Boehringer Ingelheim 14
Bristol-Myers Squibb 11
AstraZeneca 8
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Sponsor Type

Sponsor Type for DIGOXIN
Sponsor Trials
Other 173
Industry 146
NIH 12
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