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Generated: December 15, 2018

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CLINICAL TRIALS PROFILE FOR CRIXIVAN

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Clinical Trials for Crixivan

Trial ID Title Status Sponsor Phase Summary
NCT00001566 A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric Sarcomas Completed National Cancer Institute (NCI) Phase 2 This is a single arm study. The tumor specimen is analyzed for the presence of a fusion protein which corresponds to available peptides. Patients undergo T cell harvest 10 days after an initial priming peptide-pulsed antigen presenting cell (APC) vaccine is performed. Fresh APCs are utilized for initial priming vaccination. All subsequent vaccinations will use cryopreserved APCs. Minimum number of APCs administered per vaccination is 100,000/kg and maximum is 100,000,000/kg. Patients undergo cytoreductive therapy for the treatment of their particular malignancy. This therapy usually consists of multiagent chemotherapy in the context of a separate protocol. Following chemotherapy, infusion of harvested T cells followed by infusion of peptide-pulsed APC vaccinations occurs every 6 weeks for a total of 3 post-priming vaccinations. Influenza vaccine is administered by intramuscular injection concurrent to peptide-pulsed APC vaccines. Interleukin -2 (IL-2) is administered as a continuous intravenous (IV) infusion for 4 days/week for 3 successive weeks starting on the same day as T cell /peptide-pulsed infusions.
NCT00002155 A Six-Month Safety and Antiviral Study in HIV-1 Seropositive, AZT-Experienced Patients With CD4 Counts Less Than or Equal to 50 Cells/mm3 to Evaluate MK-639 Alone Versus Zidovudine (AZT) and 3TC Versus the Combination of MK-639 With AZT/3TC Completed Merck Sharp & Dohme Corp. N/A To compare effects on CD4 counts and serum viral RNA among HIV-seropositive, zidovudine (AZT)-experienced patients in three treatment arms: indinavir sulfate ( MK-639; Crixivan ) plus AZT plus lamivudine ( 3TC ) versus MK-639 alone versus AZT/3TC.
NCT00002168 A Comparison of Two Anti-HIV Triple-Drug Combinations in HIV-Infected Patients Completed Bristol-Myers Squibb N/A The purpose of this study is to compare the safety and effectiveness of two anti-HIV drug combinations when given to HIV-infected patients who have never been treated with anti-HIV drugs. One drug combination is stavudine (d4T) plus didanosine (ddI) plus Crixivan. The other combination is Retrovir (AZT) plus Epivir (3TC) plus Crixivan.
NCT00002235 A Study on the Safety and Effectiveness of Twice-Daily Nelfinavir Plus Twice-Daily Indinavir Plus Efavirenz in HIV-Positive Patients Who Have Never Taken Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) or Protease Inhibitors Completed Agouron Pharmaceuticals Phase 2 Indinavir is usually taken three times a day. The purpose of this study is to see if it is safe and effective to take indinavir only twice a day plus nelfinavir (also taken twice a day) and efavirenz (taken once a day).
NCT00002235 A Study on the Safety and Effectiveness of Twice-Daily Nelfinavir Plus Twice-Daily Indinavir Plus Efavirenz in HIV-Positive Patients Who Have Never Taken Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) or Protease Inhibitors Completed Merck Sharp & Dohme Corp. Phase 2 Indinavir is usually taken three times a day. The purpose of this study is to see if it is safe and effective to take indinavir only twice a day plus nelfinavir (also taken twice a day) and efavirenz (taken once a day).
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Crixivan

Condition Name

Condition Name for Crixivan
Intervention Trials
HIV Infections 8
Rhabdomyosarcoma 1
HIV Infection 1
Healthy 1
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Condition MeSH

Condition MeSH for Crixivan
Intervention Trials
HIV Infections 9
Infection 2
Sarcoma, Ewing 1
Sarcoma 1
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Clinical Trial Locations for Crixivan

Trials by Country

Trials by Country for Crixivan
Location Trials
United States 32
Puerto Rico 2
Switzerland 1
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Trials by US State

Trials by US State for Crixivan
Location Trials
Georgia 3
California 3
New Jersey 3
Texas 3
Pennsylvania 2
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Clinical Trial Progress for Crixivan

Clinical Trial Phase

Clinical Trial Phase for Crixivan
Clinical Trial Phase Trials
Phase 4 1
Phase 2 4
Phase 1 2
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Clinical Trial Status

Clinical Trial Status for Crixivan
Clinical Trial Phase Trials
Completed 10
Unknown status 1
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Clinical Trial Sponsors for Crixivan

Sponsor Name

Sponsor Name for Crixivan
Sponsor Trials
Merck Sharp & Dohme Corp. 3
Bristol-Myers Squibb 2
Oncology Institute of Southern Switzerland 1
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Sponsor Type

Sponsor Type for Crixivan
Sponsor Trials
Industry 8
NIH 2
Other 2
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Serving hundreds of leading biopharmaceutical companies globally:

Boehringer Ingelheim
Queensland Health
Teva
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Accenture
Merck
Fish and Richardson
Chinese Patent Office
Express Scripts

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