Comparative Efficacy Evaluation of Lipids When Treated With Niaspan & Statin or Other Lipid-Modifying Therapies-COMPELL
The purpose of this study is to evaluate the effectiveness of first-line treatment using
Niaspan (an extended release version of niacin) and statins versus other drugs that lower
lipid levels, in subjects with elevated fat levels in their blood (dyslipidemia). Statins
are a class of medication that is often prescribed to patients who need to lower their
The purpose of the study is to investigate the effects of atorvastatin (Lipitor) and
rosuvastatin (Crestor), United States Food and Drug Administration (FDA) approved drugs
commonly prescribed by doctors to lower cholesterol, on certain functions of platelets
(cells that cause blood clots), white blood cells (cells that are responsible for
inflammation), and blood flow regulation by arteries. This is important because we are
looking at ways to more effectively prevent atherosclerosis (plaque buildup in blood
vessels) and heart disease. Many studies have demonstrated that these drugs are effective at
reducing inflammation and stabilizing plaques. We are interested in better understanding the
effects of these medicines on inflammation (pain and swelling) and the mechanism by which
Hypothesis: Atorvastatin (40mg) will reduce inflammatory markers and activity more than
Rosuvastatin (10mg) in spite of equal LDL-C reduction.
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