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Last Updated: November 18, 2019

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CLINICAL TRIALS PROFILE FOR COTELLIC

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All Clinical Trials for Cotellic

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01928394 A Study of Nivolumab by Itself or Nivolumab Combined With Ipilimumab in Patients With Advanced or Metastatic Solid Tumors Recruiting Bristol-Myers Squibb Phase 1/Phase 2 2013-10-01 To investigate the safety and efficacy of Nivolumab as a single agent or in combination with Ipilimumab in 6 tumor types - triple-negative breast cancer (TNBC), gastric cancer (GC), pancreatic adenocarcinoma (PC), small cell lung cancer (SCLC), bladder cancer (BC), and ovarian cancer (OC). A combination of Nivolumab with Ipilimumab and Cobimetinib is also investigated in PC.
NCT02060188 A Study of Nivolumab and Nivolumab Plus Ipilimumab in Recurrent and Metastatic Colon Cancer (CheckMate 142) Recruiting Bristol-Myers Squibb Phase 1/Phase 2 2014-03-01 The purpose of this study is to examine if Nivolumab alone, Nivolumab in combination with Ipilimumab, or Nivolumab in combination with Ipilimumab and Cobimetinib will demonstrate a meaningful objective response rate in patients with recurrent and metastatic colon cancer who also have a specific biomarker in their tumors.
NCT02091141 A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, and Erivedge Treatment Targeted Against Certain Mutations in Cancer Patients Recruiting Genentech, Inc. Phase 2 2014-04-01 This is a multicenter, non-randomized, open-label study designed to evaluate four treatment regimens in patients with advanced cancer for whom there is no available, beneficial treatment. Patients with HER2 overexpression, amplification, or -activating mutation will be treated with Herceptin/Perjeta; those with epidermal growth factor receptor (EGFR), with Tarceva; those with BRAF-activating mutation, with Zelboraf/Cotellic; and those with Hedehog pathway potentially clinically relevant mutation, with Erivedge. Treatment will continue until disease progression or unacceptable toxicity occurs. Study is expected to last up to 5 years.
NCT03101254 LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma Recruiting Eli Lilly and Company Phase 1/Phase 2 2017-06-06 This research study is studying a combination of targeted therapies as a possible treatment for advanced melanoma that was found to have a BRAF V600E or BRAF V600K genetic mutation The interventions involved in this study are: - LY3022855 - Vemurafenib - Cobimetinib
NCT03101254 LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma Recruiting Dana-Farber Cancer Institute Phase 1/Phase 2 2017-06-06 This research study is studying a combination of targeted therapies as a possible treatment for advanced melanoma that was found to have a BRAF V600E or BRAF V600K genetic mutation The interventions involved in this study are: - LY3022855 - Vemurafenib - Cobimetinib
NCT03201458 Atezolizumab With or Without Cobimetinib in Treating Patients With Metastatic Bile Duct Cancer That Cannot Be Removed by Surgery Not yet recruiting National Cancer Institute (NCI) Phase 2 2018-04-20 This phase II trial studies how well atezolizumab with or without cobimetinib works in treating patients with bile duct cancer that has spread to other places in the body and cannot be removed by surgery. Monoclonal antibodies, such as atezolizumab, may interfere with the ability of tumor cells to grow and spread. Cobimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving atezolizumab with cobimetinib may work better at treating bile duct cancer.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Cotellic

Condition Name

Condition Name for Cotellic
Intervention Trials
Metastatic Melanoma 1
Brain Metastases 1
Stage IB Pancreatic Cancer AJCC v8 1
Non-small Cell Lung Cancer 1
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Condition MeSH

Condition MeSH for Cotellic
Intervention Trials
Melanoma 4
Carcinoma, Non-Small-Cell Lung 2
Neoplasm Metastasis 2
Adenocarcinoma 2
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Clinical Trial Locations for Cotellic

Trials by Country

Trials by Country for Cotellic
Location Trials
United States 73
Spain 4
United Kingdom 4
Germany 3
Australia 3
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Trials by US State

Trials by US State for Cotellic
Location Trials
Tennessee 6
Oregon 5
Massachusetts 5
Texas 5
California 4
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Clinical Trial Progress for Cotellic

Clinical Trial Phase

Clinical Trial Phase for Cotellic
Clinical Trial Phase Trials
Phase 3 1
Phase 2 8
Phase 1/Phase 2 6
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Clinical Trial Status

Clinical Trial Status for Cotellic
Clinical Trial Phase Trials
Not yet recruiting 8
Recruiting 7
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Clinical Trial Sponsors for Cotellic

Sponsor Name

Sponsor Name for Cotellic
Sponsor Trials
National Cancer Institute (NCI) 4
Genentech, Inc. 4
Hoffmann-La Roche 3
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Sponsor Type

Sponsor Type for Cotellic
Sponsor Trials
Other 10
Industry 10
NIH 4
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