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Last Updated: August 14, 2020

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CLINICAL TRIALS PROFILE FOR CORTICOTROPIN

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All Clinical Trials for Corticotropin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00001180 Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) N/A 1982-03-01 Corticotropin Releasing Hormone (CRH) is a hypothalamic hormone made up of 41 amino acids. Amino acids are proteins that when combined make up different substances, like hormones. The order of amino acids in CRH, has been determined, meaning that the hormone can now be synthetically reproduced in a laboratory setting. When CRH is released from the hypothalamus it stimulates the pituitary gland to secrete another hormone, ACTH. ACTH then causes the adrenal glands to make a third hormone, cortisol. This process is known as the hypothalamic-pituitary-adrenal axis. Problems can occur in any of the steps of this process and result in a variety of diseases (Cushing's Syndrome and adrenal insufficiency). Researchers hope that CRH created in a laboratory setting, ovine CRH (oCRH) can be used to help diagnose and treat conditions of the HPA axis. This study will test the relationship for single doses of oCRH in normal volunteers and patients with disorders of the HPA axis. The oCRH will be injected into the patients vein as a single injection or slowly through an IV line over 24 hours. The participants will have blood tests taken to measure hormone levels before, during, and after receiving the oCRH.
NCT00004758 Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment Completed National Institute of Neurological Disorders and Stroke (NINDS) Phase 2 1993-11-01 OBJECTIVES: I. Evaluate the efficacy of surgical resection of an identifiable zone of cortical abnormality versus multiple drug therapy in children with infantile spasms refractory to standard therapy. II. Assess how infantile spasms interfere with development and whether this is partially reversible. III. Determine the predictors of good surgical outcome and whether surgery permanently controls seizures and improves development.
NCT00004758 Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment Completed University of California, Los Angeles Phase 2 1993-11-01 OBJECTIVES: I. Evaluate the efficacy of surgical resection of an identifiable zone of cortical abnormality versus multiple drug therapy in children with infantile spasms refractory to standard therapy. II. Assess how infantile spasms interfere with development and whether this is partially reversible. III. Determine the predictors of good surgical outcome and whether surgery permanently controls seizures and improves development.
NCT00004758 Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment Completed National Center for Research Resources (NCRR) Phase 2 1993-11-01 OBJECTIVES: I. Evaluate the efficacy of surgical resection of an identifiable zone of cortical abnormality versus multiple drug therapy in children with infantile spasms refractory to standard therapy. II. Assess how infantile spasms interfere with development and whether this is partially reversible. III. Determine the predictors of good surgical outcome and whether surgery permanently controls seizures and improves development.
NCT00005890 Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock Completed Children's Hospital Medical Center, Cincinnati N/A 1996-03-01 OBJECTIVES: I. Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock. II. Examine the mortality, length of stay in the PICU, and incidence of multiorgan failure in children with adrenal dysfunction and septic shock.
NCT00005890 Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock Completed National Center for Research Resources (NCRR) N/A 1996-03-01 OBJECTIVES: I. Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock. II. Examine the mortality, length of stay in the PICU, and incidence of multiorgan failure in children with adrenal dysfunction and septic shock.
NCT00005905 Leptin to Treat Lipodystrophy Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 2 2000-06-01 This study will evaluate the safety and effectiveness of the leptin replacement therapy in treating lipoatrophy or lipodystrophy-a condition in which there is a total or partial loss of fat cells. Patients with lipodystrophy lack sufficient leptin, because this hormone is produced by fat cells. The leptin deficiency usually causes high blood lipid (fat) levels and insulin resistance that may lead to diabetes. Patients may have hormone imbalances, fertility problems, uncontrolled appetite, and liver disease due to fat accumulation. Patients 15 years and older with lipodystrophy are eligible for this study. Candidates are screened with a medical history and physical examination, and fasting blood tests. Those enrolled undergo the following additional procedures: - Ultrasound of the liver and, if abnormalities are found, possibly a liver biopsy - Resting metabolic rate measurement - measures the amount of oxygen breathed at rest in order to calculate how many calories are required to maintain resting body functions - Magnetic resonance imaging of the liver and other organs, and of muscle and fat - Estimation of body fat - measurements of height, weight, hip size, and skin folds over the arms and abdomen to estimate body fat content - Insulin tolerance test - measures blood glucose levels after administration of insulin. Insulin is given through an intravenous (IV) catheter (a thin tube placed in a vein) and blood is drawn 5 minutes before the test begins, when the test begins, and 5, 10, 15, 20 and 30 minutes into the test - Oral glucose tolerance test - measures blood glucose and insulin levels after drinking a glucose (sugar) solution. Blood samples are drawn through an IV catheter 15 minutes before the test begins, at the time the test begins, and 30, 60, 90 and 180 minutes into the test - Intravenous glucose tolerance test - measures tissue response to insulin and glucose after glucose is injected into a vein. The glucose injection is followed by a short infusion of insulin and then blood samples are taken over 3 hours to measure insulin and glucose levels - Appetite level and food intake - measures hunger level and caloric intake. Patients are questioned about their hunger level, given a variety of foods they may choose to eat and questioned again at various intervals about hunger level. On another day, patients are given breakfast (usually a milkshake) and when they want to eat again, the appetite level and caloric intake study is repeated. - Hormone function tests - the function of three hormones influenced by leptin (corticotropin-releasing hormone, thyrotropin-releasing hormone and luteinizing hormone-releasing hormone) are assessed. The hormones are injected intravenously and then blood samples are drawn. When all the tests are completed, leptin therapy begins. The drug is injected under the skin twice a day for 4 months by the patient or a caregiver (similar to self-administered insulin injections for diabetes). Blood is drawn once a month to monitor the effects of treatment and drug side effects. At clinic visits scheduled 1, 2 and 4 months after therapy starts, patients have a physical examination and meet with a dietitian. Medication dosage is also increased at these visits. At the end of 4 months, all baseline studies described above are repeated. Throughout the study, all patients complete a form once a week, in which they record their symptoms. Patients with diabetes also measure their blood glucose levels at home before each meal and at bedtime.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Corticotropin

Condition Name

Condition Name for Corticotropin
Intervention Trials
Stress Disorders, Post-Traumatic 5
Brain Tumor 4
Brain Edema 4
Healthy 4
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Condition MeSH

Condition MeSH for Corticotropin
Intervention Trials
Stress Disorders, Post-Traumatic 5
Brain Neoplasms 5
Disease 5
Brain Edema 5
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Clinical Trial Locations for Corticotropin

Trials by Country

Trials by Country for Corticotropin
Location Trials
United States 100
Canada 14
China 5
Germany 2
France 2
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Trials by US State

Trials by US State for Corticotropin
Location Trials
California 12
Maryland 11
New York 8
Michigan 7
Georgia 6
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Clinical Trial Progress for Corticotropin

Clinical Trial Phase

Clinical Trial Phase for Corticotropin
Clinical Trial Phase Trials
Phase 4 11
Phase 3 6
Phase 2 15
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Clinical Trial Status

Clinical Trial Status for Corticotropin
Clinical Trial Phase Trials
Completed 27
Not yet recruiting 6
Recruiting 6
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Clinical Trial Sponsors for Corticotropin

Sponsor Name

Sponsor Name for Corticotropin
Sponsor Trials
Mallinckrodt 6
Celtic Pharma Development Services 5
Emory University 3
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Sponsor Type

Sponsor Type for Corticotropin
Sponsor Trials
Other 48
Industry 19
NIH 16
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