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Generated: December 19, 2018

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CLINICAL TRIALS PROFILE FOR CLEVIPREX

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Clinical Trials for Cleviprex

Trial ID Title Status Sponsor Phase Summary
NCT00666328 Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE) Completed The Medicines Company Phase 3 The purpose of this study was to determine the efficacy and safety of clevidipine for treating acute hypertension (high blood pressure, defined as systolic blood pressure >160 mmHg) in patients with intracerebral hemorrhage (i.e., bleeding in the brain; stroke).
NCT00799604 Clevidipine Bolus Administration in the Treatment of Hypertensive Patients Undergoing Cardiac Surgery (SPRINT) Completed The Medicines Company Phase 2 This study was designed to evaluate the pharmacodynamics of a bolus dosing regimen of clevidipine, a vascular-selective L-type calcium channel antagonist, for the management of blood pressure in cardiac surgery patients, as well as to evaluate the efficacy, safety and pharmacokinetics of clevidipine after bolus administration.
NCT00803634 Clevidipine in the Treatment of Blood Pressure in Patients With Acute Heart Failure (PRONTO) Completed The Medicines Company Phase 3 The purpose of this study was to evaluate the efficacy and safety of intravenous (IV) clevidipine as compared with standard of care IV antihypertensive agents for blood pressure (BP) lowering in patients with acute heart failure and elevated BP.
NCT00952081 A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients Completed The Medicines Company Phase 4 This protocol describes a study to gain experience in the use of Clevidipine for perioperative blood pressure control in patients undergoing craniotomy for brain tumor or epilepsy focus resection. The purpose of this study is to establish the efficacy of Clevidipine for intraoperative blood pressure control in patients undergoing intracranial procedures, and gather information on the dosage and adverse effects of Clevidipine in neurosurgical patients. This initial pilot experience serves to familiarize the investigators with the use of this drug prior to initiating a planned randomized trial versus institutional standard-of-care therapy. The investigators will obtain greater familiarity with the dosing of clevidipine in this patient population and collect information on the incidence of adverse effects.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Cleviprex

Condition Name

Condition Name for Cleviprex
Intervention Trials
Hypertension 7
Subarachnoid Hemorrhage 3
Vasospasm, Intracranial 1
Aorta Aneurysm 1
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Condition MeSH

Condition MeSH for Cleviprex
Intervention Trials
Hypertension 6
Hemorrhage 5
Subarachnoid Hemorrhage 3
Cerebral Hemorrhage 2
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Clinical Trial Locations for Cleviprex

Trials by Country

Trials by Country for Cleviprex
Location Trials
United States 29
Germany 3
Switzerland 1
France 1
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Trials by US State

Trials by US State for Cleviprex
Location Trials
New York 3
California 3
Ohio 3
North Carolina 3
Michigan 3
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Clinical Trial Progress for Cleviprex

Clinical Trial Phase

Clinical Trial Phase for Cleviprex
Clinical Trial Phase Trials
Phase 4 5
Phase 3 2
Phase 2 3
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Clinical Trial Status

Clinical Trial Status for Cleviprex
Clinical Trial Phase Trials
Completed 4
Unknown status 4
Recruiting 2
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Clinical Trial Sponsors for Cleviprex

Sponsor Name

Sponsor Name for Cleviprex
Sponsor Trials
The Medicines Company 9
Henry Ford Health System 2
New York University School of Medicine 1
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Sponsor Type

Sponsor Type for Cleviprex
Sponsor Trials
Industry 9
Other 8
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Serving hundreds of leading biopharmaceutical companies globally:

Cerilliant
Fish and Richardson
Federal Trade Commission
Deloitte
Citi
US Army
Queensland Health
Argus Health
Daiichi Sankyo

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