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Last Updated: October 20, 2019

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CLINICAL TRIALS PROFILE FOR CLARITHROMYCIN

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Clinical Trials for Clarithromycin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000644 A Phase II Safety and Efficacy Study of Clarithromycin in the Treatment of Disseminated M. Avium Complex (MAC) Infections in Patients With AIDS Completed Abbott Phase 2 1969-12-31 This study is designed to evaluate the efficacy and safety of clarithromycin given orally at 1 of 3 doses to treat disseminated Mycobacterium avium complex infections (MAC) in patients with AIDS. Mycobacterium avium complex (MAC) is thought to be the most common disseminated bacterial opportunistic infection in AIDS, with clinical prevalence estimates ranging from 15 to 50 percent of all AIDS patients. Clarithromycin, a new macrolide antimicrobial agent, has demonstrated activity against MAC both in the laboratory and in animals. Clinical experience treating AIDS patients with clarithromycin for disseminated MAC is limited. However, early studies have indicated few adverse effects and some improvement in clinical symptoms scores and Karnofsky performance scores over placebo treated patients.
NCT00000644 A Phase II Safety and Efficacy Study of Clarithromycin in the Treatment of Disseminated M. Avium Complex (MAC) Infections in Patients With AIDS Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 1969-12-31 This study is designed to evaluate the efficacy and safety of clarithromycin given orally at 1 of 3 doses to treat disseminated Mycobacterium avium complex infections (MAC) in patients with AIDS. Mycobacterium avium complex (MAC) is thought to be the most common disseminated bacterial opportunistic infection in AIDS, with clinical prevalence estimates ranging from 15 to 50 percent of all AIDS patients. Clarithromycin, a new macrolide antimicrobial agent, has demonstrated activity against MAC both in the laboratory and in animals. Clinical experience treating AIDS patients with clarithromycin for disseminated MAC is limited. However, early studies have indicated few adverse effects and some improvement in clinical symptoms scores and Karnofsky performance scores over placebo treated patients.
NCT00000794 Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 1969-12-31 To evaluate the efficacy, safety, and tolerance of atovaquone with either pyrimethamine or sulfadiazine in AIDS patients with toxoplasmic encephalitis. AIDS patients with toxoplasmic encephalitis who receive the standard therapy combination of sulfadiazine and pyrimethamine experience a high frequency of severe toxicity. Atovaquone, an antibiotic that has demonstrated efficacy against toxoplasmosis in animal models and in preclinical testing has been well tolerated, is now available as a suspension, which is more readily absorbed than the tablet form of the drug. The efficacy and safety of atovaquone in combination with sulfadiazine or pyrimethamine will be studied.
NCT00000826 Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole-Trimethoprim and Dapsone and Their Hydroxylamine Metabolites Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 1969-12-31 To determine the effects of fluconazole and either rifabutin or clarithromycin, alone and in combination, on the pharmacokinetics of first sulfamethoxazole-trimethoprim and then dapsone in HIV-infected patients. Although prophylaxis for more than one opportunistic infection is emerging as a common clinical practice in patients with advanced HIV disease, little is known about possible adverse drug interactions. The need exists to define pharmacokinetics and pharmacodynamic adverse interactions of the many combination prophylactic regimens that may be prescribed.
NCT00000971 The Safety and Effectiveness of Clarithromycin Plus Zidovudine or Dideoxyinosine in the Treatment of Mycobacterium Avium Complex (MAC) Infections in Children With AIDS Completed National Cancer Institute (NCI) Phase 1 1969-12-31 To evaluate three doses of clarithromycin in children with AIDS and Mycobacterium avium complex (MAC) infection who are receiving concurrent antiretroviral therapy. Before more extensive evaluation of this promising drug for treatment of MAC infection in children can be done, it is important to study the pharmacokinetics of this drug in this population, to get information regarding its use in pediatric patients receiving currently available antiretroviral drugs, and to get information on the antimycobacterial activity of this drug.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Clarithromycin

Condition Name

Condition Name for Clarithromycin
Intervention Trials
Helicobacter Pylori Infection 67
Healthy 25
HIV Infections 15
Mycobacterium Avium-Intracellulare Infection 12
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Condition MeSH

Condition MeSH for Clarithromycin
Intervention Trials
Helicobacter Infections 88
Infection 62
Communicable Diseases 45
Mycobacterium Infections 22
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Clinical Trial Locations for Clarithromycin

Trials by Country

Trials by Country for Clarithromycin
Location Trials
United States 276
Taiwan 33
Korea, Republic of 25
China 24
Japan 24
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Trials by US State

Trials by US State for Clarithromycin
Location Trials
California 20
New York 19
Texas 18
Florida 16
Maryland 15
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Clinical Trial Progress for Clarithromycin

Clinical Trial Phase

Clinical Trial Phase for Clarithromycin
Clinical Trial Phase Trials
Phase 4 89
Phase 3 55
Phase 2/Phase 3 8
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Clinical Trial Status

Clinical Trial Status for Clarithromycin
Clinical Trial Phase Trials
Completed 156
Recruiting 54
Not yet recruiting 34
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Clinical Trial Sponsors for Clarithromycin

Sponsor Name

Sponsor Name for Clarithromycin
Sponsor Trials
Abbott 17
National Taiwan University Hospital 15
National Institute of Allergy and Infectious Diseases (NIAID) 9
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Sponsor Type

Sponsor Type for Clarithromycin
Sponsor Trials
Other 296
Industry 115
NIH 17
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