Fexofenadine (Allegra®) in Healthy Adults Who Have Been Identified as Slow Metabolizers for Desloratadine
To evaluate the single-dose and steady-state pharmacokinetics of desloratadine and
fexofenadine in desloratadine slow metabolizers. To evaluate the safety and tolerability of
desloratadine compared to fexofenadine following single and multiple oral doses administered
to desloratadine slow metabolizers.
Fexofenadine HCl 180 mg, Desloratadine 5 mg and Placebo in Suppression of Wheal and Flare Induced by Histamine
To examine the relative potency, onset of action and duration of action of fexofenadine HCl
180 mg (ALLEGRA) and desloratadine 5 mg (CLARINEX) as compared to placebo on skin wheals and
flares induced by histamine.
Safety of Desloratadine in Children With Allergy Sensitivity and Chronic Hives, Who Are Poor Metabolizers of Desloratadine (Study P02994)
Merck Sharp & Dohme Corp.
This study was conducted to evaluate the safety and tolerance of desloratadine after 5 weeks
of repetitive dosing in children ages 2 to 12 years old with allergic hypersensitivity or
chronic hives. All of the subjects enrolled in this trial were previously identified in an
earlier trial to be poor metabolizers of desloratadine.
Preference for Clarinex Tablets vs. Allegra Tablets in Patients With Seasonal Allergies (Study P03177)
Merck Sharp & Dohme Corp.
This was a crossover study designed to see if patients with seasonal allergy symptoms
preferred Clarinex® or Allegra®. Patients were randomized to take 7 days of Clarinex or
Allegra treatment, followed by a 5 to 28-day washout period (days when no drug is given),
followed by 7 days of the opposite treatment. At the end of each 7-day treatment, patients
were asked questions to determine which drug, Clarinex or Allegra, the patient prefers more.
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