Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
The two purposes of this study are
1. to determine what effect the chronic and moderate/heavy drinking of alcoholic beverages
1. on the blood level of bupropion and chlorzoxazone and their major breakdown
products in the blood and
2. on the stimulant effect of bupropion and
2. to determine what effect a normal and common (25% frequency) genetic variation of a
specific liver enzyme (that breaks down bupropion) has
1. on the blood levels of bupropion and its major breakdown products in the blood and
2. on the stimulant effect of bupropion.
Two groups of volunteers will be recruited for this study:
1. volunteers who drink moderate to heavy amounts of alcohol frequently and
2. volunteers who usually do not drink alcohol.
Volunteers will NOT be asked to change their drinking (or nondrinking) habits during the
Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes
University Hospital, Basel, Switzerland
The purpose of this study is to assess whether a cocktail of seven approved drugs (so-called
"Basel cocktail") can be used for simultaneous phenotyping of CYP1A2, CYP2B6, CYP2C9,
CYP2C19, CYP2D6, CYP2E1 and CYP3A4.
Placebo-Controlled Cross Over Trial of Chlorzoxazone Intake
University of California, San Francisco
The overall goals of this study are to (1) expand knowledge about interactions of
chlorzoxazone with alcohol by assessing the effects of chlorzoxazone compared to placebo in
moderate and heavy social alcohol users and (2) to compare the effects of chlorzoxazone on
visual cue induced alcohol craving to placebo in moderate to heavy social alcohol users.
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