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Last Updated: February 18, 2020

DrugPatentWatch Database Preview

CLINICAL TRIALS PROFILE FOR CHLOROPROCAINE HYDROCHLORIDE

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All Clinical Trials for Chloroprocaine Hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00487084 Effect of Timing on Efficacy of Morphine Analgesia After 2-chloroprocaine Anesthesia Completed Northwestern University N/A 2004-08-01 Epidural chloroprocaine is often used in obstetrical anesthesia because of its fast onset and short duration. These properties make it an ideal drug to use for epidural anesthesia in patients undergoing postpartum tubal ligation. When epidural morphine is given after chloroprocaine, there is a decreased efficacy of analgesia as compared to lidocaine (1). Several studies have hypothesized a specific opioid receptor mediated antagonism of chloroprocaine (2,3). Karambelkar raised the question whether this decreased efficacy is due to a disparity between the time the chloroprocaine anesthesia resolves and the onset of epidural morphine analgesia, resulting in a time window of pain (2). The duration of action of epidural 2-CP anesthesia is 30-45 minutes and the onset of epidural morphine analgesia is 60-70 minutes, therefore the regression of sensory blockade before the onset of the morphine analgesia could result in a window of pain (2). Hess and colleagues studied epidural morphine analgesia and women who had a Cesarean delivery under spinal bupivacaine anesthesia (3). Subjects were randomized to receive epidural 2-CP and morphine or epidural saline and morphine. There was no difference in postoperative analgesia between the two groups (3 and personal communication, Dr. Philip Hess). A literature search cross referencing epidural chloroprocaine, using Pub Med, did not produce any articles comparing epidural morphine given before the procedure (in an attempt to time the onset of analgesia with the resolution of chloroprocaine anesthesia) to the standard administration time after the procedure.
NCT00845962 A Comparison of Bupivacaine and 2-chloroprocaine for Spinal Anesthesia Completed Centre hospitalier de l'Université de Montréal (CHUM) N/A 2009-02-01 The purpose of this study is to compare the efficacity and the readiness for discharge between two local anesthetics, bupivacaine and 2-chloroprocaine, used for spinal anesthesia.
NCT00845962 A Comparison of Bupivacaine and 2-chloroprocaine for Spinal Anesthesia Completed Université de Montréal N/A 2009-02-01 The purpose of this study is to compare the efficacity and the readiness for discharge between two local anesthetics, bupivacaine and 2-chloroprocaine, used for spinal anesthesia.
NCT01719237 Trial Comparing the Onset and Duration of Ultrasound Guided Supraclavicular Nerve Blocks Using Ropivacaine Versus Ropivacaine-Chloroprocaine Mixture Completed VA Palo Alto Health Care System Phase 4 2009-08-01 A double blinded randomized controlled trial comparing the onset and duration of the Onset and Duration of Ultrasound Guided Supraclavicular Nerve Blocks Using a long acting local anesthestic (Ropivacaine) with a mixture of a long and short acting local anesthestic (Ropivacaine-Chloroprocaine Mixture).
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Chloroprocaine Hydrochloride

Condition Name

Condition Name for Chloroprocaine Hydrochloride
Intervention Trials
Spinal Anesthesia 3
Anesthesia, Spinal 3
Pain 3
Hernia, Inguinal 2
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Condition MeSH

Condition MeSH for Chloroprocaine Hydrochloride
Intervention Trials
Hernia, Inguinal 3
Uterine Cervical Incompetence 2
Hernia 2
Hypotension 1
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Clinical Trial Locations for Chloroprocaine Hydrochloride

Trials by Country

Trials by Country for Chloroprocaine Hydrochloride
Location Trials
United States 8
Belgium 6
Italy 5
Switzerland 2
Canada 2
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Trials by US State

Trials by US State for Chloroprocaine Hydrochloride
Location Trials
Arkansas 2
Oregon 1
North Carolina 1
New York 1
Ohio 1
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Clinical Trial Progress for Chloroprocaine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Chloroprocaine Hydrochloride
Clinical Trial Phase Trials
Phase 4 11
Phase 3 3
Phase 2 5
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Clinical Trial Status

Clinical Trial Status for Chloroprocaine Hydrochloride
Clinical Trial Phase Trials
Completed 11
Not yet recruiting 11
Recruiting 5
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Clinical Trial Sponsors for Chloroprocaine Hydrochloride

Sponsor Name

Sponsor Name for Chloroprocaine Hydrochloride
Sponsor Trials
Sintetica SA 6
Oregon Health and Science University 2
Cross Research S.A. 2
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Sponsor Type

Sponsor Type for Chloroprocaine Hydrochloride
Sponsor Trials
Other 28
Industry 12
U.S. Fed 1
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