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Last Updated: September 23, 2021

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CLINICAL TRIALS PROFILE FOR CANNABIDIOL

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505(b)(2) Clinical Trials for Cannabidiol

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
OTC NCT04423341 ↗ Effect of Non-psychoactive Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm Enrolling by invitation Benign Essential Blepharospasm Research Foundation Phase 2/Phase 3 2020-05-20 The planned study is a prospective analysis of non-psychoactive Cannabidiol (without THC) as an adjunctive therapy for blepharospasm in a masked double cross-over study. This prospective study is a follow-up to a retrospective study completed by the researchers using over-the-counter, self purchased CBD. This study will use FDA approved Cannabidiol medication, Epidiolex, directly from GW pharmaceuticals, rather than self-purchased CBD from the internet. Additionally, patients will undergo EEG monitoring via a Blink-EEG protocol for objective data measurements of changes induced by CBD in Blepharospasm patients. Independent second measures will be of blink kinematic analysis of review of video recording. Results would also be correlated with the Blepharospasm Severity Disability Index, Modified CDQ-24 scale and Jankovic Rating Scale. To assess any change in anxiety that might be relevant to therapeutic effect, the anxiety scale GAD-7 survey will also be administered and correlated with the results. This study will attempt to codify the data and quantify if adjunctive CBD therapy improves those areas compared to botulinum injection alone.
OTC NCT04423341 ↗ Effect of Non-psychoactive Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm Enrolling by invitation GW Pharmaceuticals Ltd. Phase 2/Phase 3 2020-05-20 The planned study is a prospective analysis of non-psychoactive Cannabidiol (without THC) as an adjunctive therapy for blepharospasm in a masked double cross-over study. This prospective study is a follow-up to a retrospective study completed by the researchers using over-the-counter, self purchased CBD. This study will use FDA approved Cannabidiol medication, Epidiolex, directly from GW pharmaceuticals, rather than self-purchased CBD from the internet. Additionally, patients will undergo EEG monitoring via a Blink-EEG protocol for objective data measurements of changes induced by CBD in Blepharospasm patients. Independent second measures will be of blink kinematic analysis of review of video recording. Results would also be correlated with the Blepharospasm Severity Disability Index, Modified CDQ-24 scale and Jankovic Rating Scale. To assess any change in anxiety that might be relevant to therapeutic effect, the anxiety scale GAD-7 survey will also be administered and correlated with the results. This study will attempt to codify the data and quantify if adjunctive CBD therapy improves those areas compared to botulinum injection alone.
OTC NCT04423341 ↗ Effect of Non-psychoactive Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm Enrolling by invitation Smith-Kettlewell Eye Research Institute Phase 2/Phase 3 2020-05-20 The planned study is a prospective analysis of non-psychoactive Cannabidiol (without THC) as an adjunctive therapy for blepharospasm in a masked double cross-over study. This prospective study is a follow-up to a retrospective study completed by the researchers using over-the-counter, self purchased CBD. This study will use FDA approved Cannabidiol medication, Epidiolex, directly from GW pharmaceuticals, rather than self-purchased CBD from the internet. Additionally, patients will undergo EEG monitoring via a Blink-EEG protocol for objective data measurements of changes induced by CBD in Blepharospasm patients. Independent second measures will be of blink kinematic analysis of review of video recording. Results would also be correlated with the Blepharospasm Severity Disability Index, Modified CDQ-24 scale and Jankovic Rating Scale. To assess any change in anxiety that might be relevant to therapeutic effect, the anxiety scale GAD-7 survey will also be administered and correlated with the results. This study will attempt to codify the data and quantify if adjunctive CBD therapy improves those areas compared to botulinum injection alone.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Cannabidiol

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00241592 ↗ Vaporization as a Smokeless Cannabis Delivery System Completed University of California, San Francisco Phase 1 2004-08-01 A study to evaluate the use of a vaporization system as a smokeless delivery system for inhaled marijuana.
NCT00241592 ↗ Vaporization as a Smokeless Cannabis Delivery System Completed Center for Medicinal Cannabis Research Phase 1 2004-08-01 A study to evaluate the use of a vaporization system as a smokeless delivery system for inhaled marijuana.
NCT00309413 ↗ A Clinical Trial on the Antipsychotic Properties of Cannabidiol Completed Coordinating Centre for Clinical Trials Cologne Phase 2 2006-03-01 The purpose of this study is to determine whether cannabidiol, a herbal cannabinoid, is effective in the treatment of acute schizophrenic or schizophreniform psychosis in a placebo-controlled, randomized double-blind study.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Cannabidiol

Condition Name

Condition Name for Cannabidiol
Intervention Trials
Epilepsy 17
Cannabis 15
CBD 13
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Condition MeSH

Condition MeSH for Cannabidiol
Intervention Trials
Marijuana Abuse 30
Syndrome 22
Epilepsy 14
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Clinical Trial Locations for Cannabidiol

Trials by Country

Trials by Country for Cannabidiol
Location Trials
United States 198
Canada 22
Germany 17
Israel 17
United Kingdom 16
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Trials by US State

Trials by US State for Cannabidiol
Location Trials
California 20
New York 20
Maryland 11
Massachusetts 11
Pennsylvania 11
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Clinical Trial Progress for Cannabidiol

Clinical Trial Phase

Clinical Trial Phase for Cannabidiol
Clinical Trial Phase Trials
Phase 4 10
Phase 3 34
Phase 2/Phase 3 15
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Clinical Trial Status

Clinical Trial Status for Cannabidiol
Clinical Trial Phase Trials
Not yet recruiting 133
Recruiting 56
Completed 30
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Clinical Trial Sponsors for Cannabidiol

Sponsor Name

Sponsor Name for Cannabidiol
Sponsor Trials
GW Research Ltd 24
GW Pharmaceuticals Ltd. 13
INSYS Therapeutics Inc 12
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Sponsor Type

Sponsor Type for Cannabidiol
Sponsor Trials
Other 277
Industry 90
NIH 15
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