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Last Updated: March 28, 2024

CLINICAL TRIALS PROFILE FOR CORLOPAM


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All Clinical Trials for CORLOPAM

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00122018 ↗ An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery Completed Abbott Phase 2 2002-05-01 Patients with abnormal kidney function are at increased risk for complications following heart surgery, including worsening kidney function possibly requiring dialysis, a prolonged stay in the critical care unit and hospital, and the increased risk of death. Prior attempts at kidney protection for heart surgery patients have had mixed results. Two medicines, fenoldopam and N-acetylcysteine, have been shown to protect kidney function in other circumstances that cause kidney stress. The purpose of this study is to determine whether these medications will help to maintain the function of diseased kidneys during heart surgery.
NCT00122018 ↗ An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery Completed Linda F. Barr, M.D. Phase 2 2002-05-01 Patients with abnormal kidney function are at increased risk for complications following heart surgery, including worsening kidney function possibly requiring dialysis, a prolonged stay in the critical care unit and hospital, and the increased risk of death. Prior attempts at kidney protection for heart surgery patients have had mixed results. Two medicines, fenoldopam and N-acetylcysteine, have been shown to protect kidney function in other circumstances that cause kidney stress. The purpose of this study is to determine whether these medications will help to maintain the function of diseased kidneys during heart surgery.
NCT00621790 ↗ Fenoldopam and Acute Renal Failure Completed Università Vita-Salute San Raffaele Phase 3 2008-02-01 Patients undergoing cardiac surgery could develop postoperative acute renal failure requiring renal replacement therapy. Fenoldopam, already used for patients with hypertensive emergencies, could improve renal function in critically ill patients with or at risk for acute renal failure.
NCT00747331 ↗ Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed IRCCS Policlinico S. Donato Phase 4 2008-09-01 Cardiopulmonary bypass (CPB) for cardiac operations may be accompanied by different patterns of visceral underperfusion. This could result in clinical patterns of lactic acidosis but in the most severe cases there is the risk for mesenteric infarction (0.2% of the cases). Renal function as well may be impaired due to a low oxygen delivery, and acute renal failure occurs in 1-2% of cases. Fenoldopam mesilate is a selective splanchnic vasodilator when used at a dose < 0.1 mcg/kg/min. The experimental hypothesis of this randomized, controlled trial (RCT) is that the use of fenoldopam may determine a better visceral perfusion during CPB.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for CORLOPAM

Condition Name

Condition Name for CORLOPAM
Intervention Trials
Kidney Failure, Acute 2
Cardiac Complications 1
Cardiac Surgical Procedures 1
Cardiopulmonary Bypass 1
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Condition MeSH

Condition MeSH for CORLOPAM
Intervention Trials
Acute Kidney Injury 3
Renal Insufficiency 3
Kidney Failure, Chronic 1
Hypertension 1
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Clinical Trial Locations for CORLOPAM

Trials by Country

Trials by Country for CORLOPAM
Location Trials
Italy 3
United States 1
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Trials by US State

Trials by US State for CORLOPAM
Location Trials
District of Columbia 1
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Clinical Trial Progress for CORLOPAM

Clinical Trial Phase

Clinical Trial Phase for CORLOPAM
Clinical Trial Phase Trials
Phase 4 1
Phase 3 2
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for CORLOPAM
Clinical Trial Phase Trials
Completed 5
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Clinical Trial Sponsors for CORLOPAM

Sponsor Name

Sponsor Name for CORLOPAM
Sponsor Trials
Abbott 1
Linda F. Barr, M.D. 1
Università Vita-Salute San Raffaele 1
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Sponsor Type

Sponsor Type for CORLOPAM
Sponsor Trials
Other 6
Industry 1
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