Flavopiridol in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
Completed
National Cancer Institute (NCI)
Phase 2
2000-06-01
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from
dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of flavopiridol in treating patients who
have recurrent or metastatic head and neck cancer.
A Study of the Onset and Offset of Antiplatelet Effects Comparing Ticagrelor, Clopidogrel, and Placebo With Aspirin
Completed
AstraZeneca
Phase 2
2007-10-01
The purpose of this study is to see how Ticagrelor, a new oral reversible anti-platelet
medication, affects platelets. Anti-platelet agents are medications that block the formation
of blood clots by preventing the clumping of platelets. Blood clots prevent us from bleeding,
but when they form inside the arteries their formation is linked to a risk of medical
problems such as heart attack and stroke. This study investigated how long it takes for
Ticagrelor to begin working and how long it takes for it to stop working after the last dose
of drug. Ticagrelor will be compared to clopidogrel, an established anti-platelet treatment
for preventing blood clots, and placebo plus Aspirin.
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