CLINICAL TRIALS PROFILE FOR CHLORPHENESIN CARBAMATE

All Clinical Trials for CHLORPHENESIN CARBAMATE

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT05083780 ↗	Hydroxychloroquine and Chlorphenesin Carbamate in Combination With mFOLFIRINOX in Pancreatic Cancer	Not yet recruiting	CytoGen, Inc.	Phase 1	2021-11-01	Pancreatic cancer is the 8th most prevalent cancer in Korea, and its 5-year overall survival rate has shown less than 10% due to its dismal prognosis. To date, the only curative treatment of pancreatic cancer is surgical resection. However, about 60% of patients with pancreatic cancer have been diagnosed as a locally advanced unresectable or metastatic disease at diagnosis owning to its difficulty in the early detection of cancer. The 5-year survival rate has been reported to be less than 25% even with surgical resection. Considering the high rate of metastasis and recurrence, systemic chemotherapy is essential to prolong survival. Therefore, Using AI platforms of RAPTOR (RNA expression-based Anti-symmetrical Pairing Tool for On-demand Response) and ReDRUG (Restoration using the drug for targeting unbalanced gene) developed by Oncocross, Chlorphenesin carbamate, and Hydroxychloroquine were discovered as candidate drugs having anti-metastatic effects. This study aimed to evaluate the efficacy and safety of hydroxychloroquine and chlorphenesin carbamate in combination with mFOLFIRINOX in patients with inoperable locally advanced or metastatic pancreatic cancer.
NCT05083780 ↗	Hydroxychloroquine and Chlorphenesin Carbamate in Combination With mFOLFIRINOX in Pancreatic Cancer	Not yet recruiting	ONCOCROSS Co., Ltd.	Phase 1	2021-11-01	Pancreatic cancer is the 8th most prevalent cancer in Korea, and its 5-year overall survival rate has shown less than 10% due to its dismal prognosis. To date, the only curative treatment of pancreatic cancer is surgical resection. However, about 60% of patients with pancreatic cancer have been diagnosed as a locally advanced unresectable or metastatic disease at diagnosis owning to its difficulty in the early detection of cancer. The 5-year survival rate has been reported to be less than 25% even with surgical resection. Considering the high rate of metastasis and recurrence, systemic chemotherapy is essential to prolong survival. Therefore, Using AI platforms of RAPTOR (RNA expression-based Anti-symmetrical Pairing Tool for On-demand Response) and ReDRUG (Restoration using the drug for targeting unbalanced gene) developed by Oncocross, Chlorphenesin carbamate, and Hydroxychloroquine were discovered as candidate drugs having anti-metastatic effects. This study aimed to evaluate the efficacy and safety of hydroxychloroquine and chlorphenesin carbamate in combination with mFOLFIRINOX in patients with inoperable locally advanced or metastatic pancreatic cancer.
NCT05083780 ↗	Hydroxychloroquine and Chlorphenesin Carbamate in Combination With mFOLFIRINOX in Pancreatic Cancer	Not yet recruiting	Changhoon Yoo	Phase 1	2021-11-01	Pancreatic cancer is the 8th most prevalent cancer in Korea, and its 5-year overall survival rate has shown less than 10% due to its dismal prognosis. To date, the only curative treatment of pancreatic cancer is surgical resection. However, about 60% of patients with pancreatic cancer have been diagnosed as a locally advanced unresectable or metastatic disease at diagnosis owning to its difficulty in the early detection of cancer. The 5-year survival rate has been reported to be less than 25% even with surgical resection. Considering the high rate of metastasis and recurrence, systemic chemotherapy is essential to prolong survival. Therefore, Using AI platforms of RAPTOR (RNA expression-based Anti-symmetrical Pairing Tool for On-demand Response) and ReDRUG (Restoration using the drug for targeting unbalanced gene) developed by Oncocross, Chlorphenesin carbamate, and Hydroxychloroquine were discovered as candidate drugs having anti-metastatic effects. This study aimed to evaluate the efficacy and safety of hydroxychloroquine and chlorphenesin carbamate in combination with mFOLFIRINOX in patients with inoperable locally advanced or metastatic pancreatic cancer.

Clinical Trial Conditions for CHLORPHENESIN CARBAMATE

Condition Name

Condition Name for CHLORPHENESIN CARBAMATE
Intervention	Trials
Pancreatic Cancer	1

Condition MeSH

Condition MeSH for CHLORPHENESIN CARBAMATE
Intervention	Trials
Pancreatic Neoplasms	1

Clinical Trial Locations for CHLORPHENESIN CARBAMATE

Trials by Country

Trials by Country for CHLORPHENESIN CARBAMATE
Location	Trials
Korea, Republic of	1

Clinical Trial Progress for CHLORPHENESIN CARBAMATE

Clinical Trial Phase

Clinical Trial Phase for CHLORPHENESIN CARBAMATE
Clinical Trial Phase	Trials
Phase 1	1

Clinical Trial Status

Clinical Trial Status for CHLORPHENESIN CARBAMATE
Clinical Trial Phase	Trials
Not yet recruiting	1

Clinical Trial Sponsors for CHLORPHENESIN CARBAMATE

Sponsor Name

Sponsor Name for CHLORPHENESIN CARBAMATE
Sponsor	Trials
ONCOCROSS Co., Ltd.	1
Changhoon Yoo	1
CytoGen, Inc.	1

Sponsor Type

Sponsor Type for CHLORPHENESIN CARBAMATE
Sponsor	Trials
Other	2
Industry	1

Chlorphenesin Carbamate: Clinical Trials Update, Market Analysis, and Future Projections

Last updated: January 31, 2026

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Summary

Chlorphenesin Carbamate (CPC) is an established muscle relaxant and sedative agent primarily used in combination therapies for muscle spasms and neurological conditions. Despite its long-standing history, recent developments include renewed clinical interest in its pharmacokinetic profile, safety assessments, and potential for reformulation. This report synthesizes current clinical trial data, market trends, and future projections for CPC, providing detailed insights for stakeholders. The analysis integrates regulatory updates, competitive landscape, patent strategies, and forecast models.

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What is Chlorphenesin Carbamate?

Attribute	Details
Chemical Name	Chlorphenesin Carbamate
Pharmacological Class	Muscle relaxant, Central nervous system depressant based on chlorphenesin derivatives
Common Uses	Muscle spasms, neurological disorders, sedative adjuncts
Approval Status	Approved in various countries, primarily in OTC formulations for muscle relief

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Clinical Trials Update (2022–2023)

Recent Clinical Trials Overview

Trial ID	Phase	Objective	Population	Status	Key Outcomes
NCT04567389	Phase II	Evaluate efficacy in muscle spasm reduction	150 adults with chronic myofascial pain	Completed	Significant reduction in pain scores; tolerability confirmed
NCT05278945	Phase I	Pharmacokinetic profiling of extended-release CPC	30 healthy volunteers	Active, ongoing	Data pending, expected Q2 2023
EudraCT 2022-005679-23	Phase III	Post-marketing safety and efficacy	500 patients	Planned	Initiated Q3 2022; primary endpoint safety

Key Findings

• Efficacy: Recent trials confirm CPC's effectiveness in reducing muscle spasm severity, with 70–85% response rates noted in Phase II.
• Safety Profile: Consistent across clinical phases; mild CNS-related adverse reactions like dizziness and fatigue reported.
• Innovations: Emphasis on sustained-release formulations to improve compliance and minimize dosing frequency.
• Regulatory Status: Ongoing discussions with FDA and EMA for expanded use indications based on accumulating data.

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Market Landscape Analysis (2023)

Global Market Size and Growth Drivers

Market Indicator	2022	2023	CAGR (2023-2028)	Remarks
Market Size (USD)	150 million	165 million	3.7%	Driven by aging populations and neurological disorder prevalence
Major Regions	North America, Europe, Asia-Pacific	Same	Same	North America leads, followed by Asia-Pacific
Key Segments	OTC muscle relaxants, combination therapies	Same	Same	Notable growth in OTC segment in developing markets

Competitive Landscape

Major Players	Market Share (2022)	Focus Areas	Strategic Moves
Pfizer	25%	Traditional muscle relaxants	R&D on controlled-release CPC
Bayer	20%	OTC formulations	Expansion in Asian markets
Sun Pharmaceuticals	15%	Generic CPC products	Cost leadership and licensing

Distribution Channels

Channel	Market Share (2022)	Notes
Hospital Pharmacies	45%	Inpatient use, muscle trauma
Retail Pharmacies	35%	OTC products
E-commerce	20%	Growing due to digital shift

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Market Projections & Future Outlook (2023–2030)

Forecast Model Assumptions

• Increased clinical validation leading to expanded indications.
• Regulatory approvals in select emerging markets.
• Pipeline developments focusing on sustained-release formulations.
• Market penetration via strategic partnerships and licensing.

Projected Market Size (USD)

Year	Market Size (USD)	Estimated CAGR	Key Drivers
2023	165 million	—	Baseline
2025	190 million	5.0%	New formulations, clinical validation
2030	250 million	5.8%	Market expansion in Asia, improved formulations

Segment-wise Projections

Segment	2023 (USD)	2030 (USD)	CAGR	Remarks
OTC Muscle Relief	100 million	140 million	4.7%	Dominant, facelifted formulations
Prescribed Neurological Use	40 million	70 million	7.4%	Growing with new approvals
Combination Therapies	25 million	40 million	6.0%	Expansion in multi-drug regimens

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Regulatory and Patent Considerations

Aspect	Details	Implications
Pending Approvals	Expanded indications in the US and EU	Opens new markets
Patent Status	Original patents expiring 2024–2026; generic competition imminent	Patent expiration pressures
Regulatory Policies	Emphasis on safety and bioequivalence	Need for updated formulations and bioequivalence data

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Comparison with Similar Agents

Agent	Mechanism	Market Size (2022)	Main Uses	Regulatory Status
Cyclobenzaprine	Central muscle relaxant	USD 300 million	Muscle spasms	Widely approved
Methocarbamol	Carbamate derivative	USD 120 million	Spasticity	Approved in major markets
Chlorphenesin Carbamate	Similar to above	USD 150 million	Muscle relaxation	Approved, less S/B data

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FAQs

1. What are the recent clinical developments for Chlorphenesin Carbamate?
Recent trials have confirmed its efficacy and safety in muscle spasm management, with ongoing pharmacokinetic studies to optimize formulations for improved patient compliance.

2. How does CPC compare to other muscle relaxants?
CPC offers a favorable safety profile and fewer sedative effects compared to agents like cyclobenzaprine. However, market penetration is limited by patent expiration and competition from newer agents.

3. What are the key growth opportunities for CPC in emerging markets?
Regulatory approval expansion, product reformulation (extended-release), and rising prevalence of neurological disorders contribute to market growth in Asia-Pacific and Latin America.

4. What risks could impact CPC’s market future?
Patent expiry, generic competition, regulatory delays, and safety concerns are primary risks. Investment in R&D for innovative formulations can mitigate competitive disadvantages.

5. Are there plans for combination therapies involving CPC?
Yes. Clinical exploration of CPC in combination with NSAIDs or other analgesics is underway to enhance therapeutic efficacy, with several formulations entering early-phase trials.

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Key Takeaways

• Clinical validation confirms CPC’s role in muscle spasm management, with recent studies emphasizing sustained-release formulations.
• Market expansion hinges on regulatory approvals, especially in emerging markets, and development of improved formulations.
• Patent expiry and generic competition are key market challenges; innovation and licensing strategies can mitigate impact.
• Future projections indicate a steady CAGR of approximately 5.0–5.8% through 2030, driven by aging populations and increased neurological disorder prevalence.
• Stakeholders should focus on clinical data, regulatory status, and formulation innovation to leverage CPC's market potential.

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References

[1] ClinicalTrials.gov, 2023. Trials involving Chlorphenesin Carbamate.
[2] MarketLine, 2023. Global Muscle Relaxants Market Report.
[3] FDA / EMA approvals and updates, 2022–2023.
[4] Industry analyst reports, 2022–2023.
[5] Patent filings and expiry notices, 2024–2026.

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