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Last Updated: March 28, 2024

CLINICAL TRIALS PROFILE FOR CETYLEV


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All Clinical Trials for CETYLEV

Trial ID Title Status Sponsor Phase Start Date Summary
NCT04013555 ↗ The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia Recruiting University of Maryland Phase 1/Phase 2 2020-01-20 Kynurenic acid (KYNA) is a naturally occurring chemical in the brain. Studies with rodents indicate that levels of KYNA can impact levels of the neurotransmitters glutamate and dopamine. One way to reliably increase KYNA levels is by ingesting the amino acid tryptophan. Tryptophan is a normal part of the human diet. Tryptophan gets metabolized/changed to other chemicals in the body- including KYNA. By giving people 6 grams of tryptophan, the investigators will be able to increase the KYNA level in a controlled way. The investigators will then be able to study the effects of KYNA on neurotransmitters by using cognitive tests and magnetic resonance imaging techniques (measuring brain activity and brain chemistry using the MRI magnet). The overall goal of the study is to examine how the medication N-acetylcysteine (NAC), when added to tryptophan, affects various cognitive functions, such as verbal and visual memory. The investigators will also use magnetic resonance imaging (MRI) to examine how NAC affects brain activity and chemicals.
NCT04013555 ↗ The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia Recruiting University of Maryland, Baltimore Phase 1/Phase 2 2020-01-20 Kynurenic acid (KYNA) is a naturally occurring chemical in the brain. Studies with rodents indicate that levels of KYNA can impact levels of the neurotransmitters glutamate and dopamine. One way to reliably increase KYNA levels is by ingesting the amino acid tryptophan. Tryptophan is a normal part of the human diet. Tryptophan gets metabolized/changed to other chemicals in the body- including KYNA. By giving people 6 grams of tryptophan, the investigators will be able to increase the KYNA level in a controlled way. The investigators will then be able to study the effects of KYNA on neurotransmitters by using cognitive tests and magnetic resonance imaging techniques (measuring brain activity and brain chemistry using the MRI magnet). The overall goal of the study is to examine how the medication N-acetylcysteine (NAC), when added to tryptophan, affects various cognitive functions, such as verbal and visual memory. The investigators will also use magnetic resonance imaging (MRI) to examine how NAC affects brain activity and chemicals.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for CETYLEV

Condition Name

Condition Name for CETYLEV
Intervention Trials
Schizoaffective Disorder 1
Schizophrenia 1
Schizophreniform Disorder 1
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Condition MeSH

Condition MeSH for CETYLEV
Intervention Trials
Disease 1
Schizophrenia 1
Psychotic Disorders 1
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Clinical Trial Locations for CETYLEV

Trials by Country

Trials by Country for CETYLEV
Location Trials
United States 1
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Trials by US State

Trials by US State for CETYLEV
Location Trials
Maryland 1
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Clinical Trial Progress for CETYLEV

Clinical Trial Phase

Clinical Trial Phase for CETYLEV
Clinical Trial Phase Trials
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for CETYLEV
Clinical Trial Phase Trials
Recruiting 1
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Clinical Trial Sponsors for CETYLEV

Sponsor Name

Sponsor Name for CETYLEV
Sponsor Trials
University of Maryland 1
University of Maryland, Baltimore 1
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Sponsor Type

Sponsor Type for CETYLEV
Sponsor Trials
Other 2
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