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Last Updated: October 18, 2019

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CLINICAL TRIALS PROFILE FOR BUPHENYL

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Clinical Trials for Buphenyl

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00345605 Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 2 2008-02-01 Urea cycle disorders are inherited illnesses in which the body does not produce enough of the chemicals that remove ammonia, a byproduct of protein metabolism, from the blood stream. Elevated ammonia levels can lead to brain damage and death. Argininosuccinic aciduria (ASA) is a type of urea cycle disorder that is characterized specifically by high levels of argininosuccinic acid, a chemical involved in the urea cycle. People with ASA are at risk for serious liver damage, which may be due to the elevated levels of argininosuccinic acid. Sodium phenylbutyrate (Buphenyl-TM) is a drug that has been used to treat other types of urea cycle disorders. This study will evaluate whether Buphenyl-TM in conjunction with decreased arginine dose (in addition to a normal regimen of protein) will improve short-term liver function and decrease plasma citrulline and ASA levels in people with ASA.
NCT00345605 Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder Completed Office of Rare Diseases (ORD) Phase 2 2008-02-01 Urea cycle disorders are inherited illnesses in which the body does not produce enough of the chemicals that remove ammonia, a byproduct of protein metabolism, from the blood stream. Elevated ammonia levels can lead to brain damage and death. Argininosuccinic aciduria (ASA) is a type of urea cycle disorder that is characterized specifically by high levels of argininosuccinic acid, a chemical involved in the urea cycle. People with ASA are at risk for serious liver damage, which may be due to the elevated levels of argininosuccinic acid. Sodium phenylbutyrate (Buphenyl-TM) is a drug that has been used to treat other types of urea cycle disorders. This study will evaluate whether Buphenyl-TM in conjunction with decreased arginine dose (in addition to a normal regimen of protein) will improve short-term liver function and decrease plasma citrulline and ASA levels in people with ASA.
NCT00345605 Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder Completed Rare Diseases Clinical Research Network Phase 2 2008-02-01 Urea cycle disorders are inherited illnesses in which the body does not produce enough of the chemicals that remove ammonia, a byproduct of protein metabolism, from the blood stream. Elevated ammonia levels can lead to brain damage and death. Argininosuccinic aciduria (ASA) is a type of urea cycle disorder that is characterized specifically by high levels of argininosuccinic acid, a chemical involved in the urea cycle. People with ASA are at risk for serious liver damage, which may be due to the elevated levels of argininosuccinic acid. Sodium phenylbutyrate (Buphenyl-TM) is a drug that has been used to treat other types of urea cycle disorders. This study will evaluate whether Buphenyl-TM in conjunction with decreased arginine dose (in addition to a normal regimen of protein) will improve short-term liver function and decrease plasma citrulline and ASA levels in people with ASA.
NCT00345605 Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder Completed Brendan Lee Phase 2 2008-02-01 Urea cycle disorders are inherited illnesses in which the body does not produce enough of the chemicals that remove ammonia, a byproduct of protein metabolism, from the blood stream. Elevated ammonia levels can lead to brain damage and death. Argininosuccinic aciduria (ASA) is a type of urea cycle disorder that is characterized specifically by high levels of argininosuccinic acid, a chemical involved in the urea cycle. People with ASA are at risk for serious liver damage, which may be due to the elevated levels of argininosuccinic acid. Sodium phenylbutyrate (Buphenyl-TM) is a drug that has been used to treat other types of urea cycle disorders. This study will evaluate whether Buphenyl-TM in conjunction with decreased arginine dose (in addition to a normal regimen of protein) will improve short-term liver function and decrease plasma citrulline and ASA levels in people with ASA.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Buphenyl

Condition Name

Condition Name for Buphenyl
Intervention Trials
Byler Disease 2
Urea Cycle Disorders 2
Argininosuccinic Aciduria 1
Maple Syrup Urine Disease 1
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Condition MeSH

Condition MeSH for Buphenyl
Intervention Trials
Urea Cycle Disorders, Inborn 2
Cholestasis, Intrahepatic 2
Maple Syrup Urine Disease 1
Disease 1
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Clinical Trial Locations for Buphenyl

Trials by Country

Trials by Country for Buphenyl
Location Trials
United States 7
Ukraine 1
Canada 1
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Trials by US State

Trials by US State for Buphenyl
Location Trials
Texas 3
Pennsylvania 1
Maryland 1
Alabama 1
Minnesota 1
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Clinical Trial Progress for Buphenyl

Clinical Trial Phase

Clinical Trial Phase for Buphenyl
Clinical Trial Phase Trials
Phase 4 1
Phase 2/Phase 3 1
Phase 2 2
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Clinical Trial Status

Clinical Trial Status for Buphenyl
Clinical Trial Phase Trials
Completed 4
No longer available 2
Active, not recruiting 1
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Clinical Trial Sponsors for Buphenyl

Sponsor Name

Sponsor Name for Buphenyl
Sponsor Trials
Horizon Pharma Ireland, Ltd., Dublin Ireland 2
Brendan Lee 2
University of Pittsburgh 2
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Sponsor Type

Sponsor Type for Buphenyl
Sponsor Trials
Other 10
Industry 2
NIH 2
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