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Generated: February 24, 2019

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CLINICAL TRIALS PROFILE FOR BRIGATINIB

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Clinical Trials for Brigatinib

Trial ID Title Status Sponsor Phase Summary
NCT02706626 Trial of Brigatinib After Treatment With Second-Generation ALK Inhibitors Not yet recruiting Ariad Pharmaceuticals Phase 2 The purpose of this study is to evaluate the safety and effectiveness of this investigational drug, brigatinib (AP261136) in patients with advanced non-small cell lung cancer Non-small cell lung cancer (NSCLC) who have had first-line treatment for their cancer and it still got worse, even after, or while taking drugs called ALK inhibitors, or anti-cancer drugs that act on tumors. Some examples of these anti-cancer drugs are: KEYTRUDA® or ALECENSA®).
NCT02706626 Trial of Brigatinib After Treatment With Second-Generation ALK Inhibitors Not yet recruiting Duke University Phase 2 The purpose of this study is to evaluate the safety and effectiveness of this investigational drug, brigatinib (AP261136) in patients with advanced non-small cell lung cancer Non-small cell lung cancer (NSCLC) who have had first-line treatment for their cancer and it still got worse, even after, or while taking drugs called ALK inhibitors, or anti-cancer drugs that act on tumors. Some examples of these anti-cancer drugs are: KEYTRUDA® or ALECENSA®).
NCT02706626 Trial of Brigatinib After Treatment With Second-Generation ALK Inhibitors Not yet recruiting University of Colorado, Denver Phase 2 The purpose of this study is to evaluate the safety and effectiveness of this investigational drug, brigatinib (AP261136) in patients with advanced non-small cell lung cancer Non-small cell lung cancer (NSCLC) who have had first-line treatment for their cancer and it still got worse, even after, or while taking drugs called ALK inhibitors, or anti-cancer drugs that act on tumors. Some examples of these anti-cancer drugs are: KEYTRUDA® or ALECENSA®).
NCT02706626 Trial of Brigatinib After Treatment With Second-Generation ALK Inhibitors Not yet recruiting Criterium, Inc. Phase 2 The purpose of this study is to evaluate the safety and effectiveness of this investigational drug, brigatinib (AP261136) in patients with advanced non-small cell lung cancer Non-small cell lung cancer (NSCLC) who have had first-line treatment for their cancer and it still got worse, even after, or while taking drugs called ALK inhibitors, or anti-cancer drugs that act on tumors. Some examples of these anti-cancer drugs are: KEYTRUDA® or ALECENSA®).
NCT02737501 ALTA-1L Study: A Phase 3 Study of Brigatinib Versus Crizotinib in ALK-positive Advanced Non-Small Cell Lung Cancer Patients Recruiting Ariad Pharmaceuticals Phase 3 A Phase 3 Multicenter Open-label Study of Brigatinib (AP26113) versus Crizotinib in ALK-positive Advanced Lung Cancer Patients
NCT02784158 An Expanded Access Study of Brigatinib for Patients With ALK-positive Advanced Non-Small Cell Lung Cancer Available Ariad Pharmaceuticals N/A The purpose of this study is to provide brigatinib for those patients with locally advanced and/or metastatic patients with ALK+ NSCLC on an expanded access basis due to their inability to meet eligibility criteria for on-going recruiting trials, inability to participate in other clinical trials (e.g., poor performance status, lack of geographic proximity), or because other medical interventions are not considered appropriate or acceptable.
NCT03410108 Phase 2 Study of Brigatinib in Japanese Patients With ALK-Positive Non-Small Cell Lung Cancer (NSCLC) Recruiting Takeda Phase 2 The purpose of this study is to evaluate efficacy and safety of Brigatinib in Japanese patients with anaplastic lymphoma kinase (ALK)-positive NSCLC that has progressed after 1 or 2 lines of prior ALK inhibitor therapy.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Brigatinib

Condition Name

Condition Name for Brigatinib
Intervention Trials
ALK-positive Advanced NSCLC 3
Non-small Cell Lung Cancer 3
Stage IV Lung Cancer AJCC v8 2
Carcinoma 2
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Condition MeSH

Condition MeSH for Brigatinib
Intervention Trials
Carcinoma, Non-Small-Cell Lung 8
Lung Neoplasms 5
Carcinoma 3
Lymphoma, Non-Hodgkin 1
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Clinical Trial Locations for Brigatinib

Trials by Country

Trials by Country for Brigatinib
Location Trials
United States 21
Japan 18
France 8
Italy 7
Germany 7
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Trials by US State

Trials by US State for Brigatinib
Location Trials
Virginia 2
Texas 2
North Carolina 2
Michigan 2
Florida 2
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Clinical Trial Progress for Brigatinib

Clinical Trial Phase

Clinical Trial Phase for Brigatinib
Clinical Trial Phase Trials
Phase 3 2
Phase 2 5
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for Brigatinib
Clinical Trial Phase Trials
Not yet recruiting 7
Recruiting 2
Available 1
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Clinical Trial Sponsors for Brigatinib

Sponsor Name

Sponsor Name for Brigatinib
Sponsor Trials
Ariad Pharmaceuticals 6
National Cancer Institute (NCI) 2
University of Colorado, Denver 1
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Sponsor Type

Sponsor Type for Brigatinib
Sponsor Trials
Industry 8
Other 4
NIH 2
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Serving hundreds of leading biopharmaceutical companies globally:

AstraZeneca
QuintilesIMS
Moodys
McKinsey
Teva
Cantor Fitzgerald
US Army
Fish and Richardson
Covington

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