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Generated: June 26, 2019

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CLINICAL TRIALS PROFILE FOR BETAMETHASONE VALERATE

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Clinical Trials for Betamethasone Valerate

Trial ID Title Status Sponsor Phase Summary
NCT00608673 Comparing the Therapeutic Efficacy of Pimecrolimus Cream With Betamethasone Cream for Discoid Lupus Erythematosus Completed Shahid Beheshti University of Medical Sciences N/A Discoid lupus erythematosus lesions are commonly treated with corticosteroids, but corticosteroids may induce side effects such as thinning of the skin or scarring. Therefore, an alternative medication with the same efficacy, but without the side-effects is sought after. Pimecrolimus is a newer drug specially designed to treat inflammatory diseases of skin. Its efficacy in treating discoid lupus erythematosus has not been studied extensively yet. However studies performed till now show promising results. Long-term topical use of this medication has not shown any serious side-effects in other skin diseases. In this study we aimed at comparing pimecrolimus efficacy with that of a common therapeutic choice, betamethasone valerate 0.1% cream, to see if pimecrolimus can be used as an alternative medication in treating discoid lupus erythematosus.
NCT01011621 Efficacy and Tolerability of Prednisolone Acetate 0.5% Cream Versus Betamethasone Valerate 0.1% Cream in Cortisosensitive Dermatosis Unknown status Mantecorp Industria Quimica e Farmaceutica Ltd. Phase 3 Topical corticosteroids are largely used in dermatology. The major problem related to their use is that the same mechanisms underlying their therapeutic effects (antiinflammatory and antiproliferative) may lead to adverse events. Conditions sensitive to corticosteroids require formulations with mild to moderate potency while high-potency corticosteroids era required in less responsive conditions. The aim of the present study is to compare the safety and efficacy of prednisolone acetate 0.5% cream (mild-potency non-fluoridated corticosteroid) versus betamethasone valerate 0.1% cream (high-potency fluoridated corticosteroid) in the treatment of mild to moderate cortisosensitive dermatosis (atopic dermatitis, contact dermatitis, seborrheic dermatitis and psoriasis). The study hypothesis is that 0.5% prednisolone cream will be as effective as 0.1% betamethasone cream and will be an alternative option to treat corticosensitive dermatosis in body areas where the use of fluoridated corticosteroids is contraindicated, such as the face.
NCT01132079 Pimecrolimus and Epidermal Barrier Function Completed Deutsche Forschungsgemeinschaft, Bonn, Germany N/A This study seeks to investigate the role of pimecrolimus in restoring disturbed skin barrier function and reversing epidermal abnormalities found in atopic dermatitis (AD). The project is based on findings the investigators presented at the recent SID meeting in Providence and published in the J Invest Dermatol (122: 1423-31, 2004). The investigators research shows that AD is characterized by impaired skin barrier function, reduced stratum corneum hydration, impaired epidermal lipid composition and epidermal differentiation. In this proposed project, the investigators wish to examine the influence of pimecrolimus and betamethasone valerate on transepidermal water loss (TEWL) as a marker of the skin barrier function, on stratum corneum hydration, on stratum corneum lipid content and on epidermal differentiation regarding keratins and cornified envelope proteins in AD patients. The study involves biophysical measurements of TEWL and skin hydration, lipid analysis, immuno-histochemistry, Western blotting and micro array techniques. This study shall clarify whether pimecrolimus restores the epidermal barrier and whether this contributes to the beneficial effect of pimecrolimus on AD. Objectives: To explore the stratum corneum hydration, transepidermal water loss, capacity for barrier repair and the integrity of the stratum corneum in patients treated with 1 % pimecrolimus cream when applied twice a day to atopic dermatitis of the upper limbs, and to access the substance's influences on the epidermis through histological, ultra-structural, and biochemical analysis using punch biopsies from day 1 of one arm and day 22 from both treated arms. 0.1 % betamethasone valerate cream b.i.d will be used as a control treatment.
NCT01132079 Pimecrolimus and Epidermal Barrier Function Completed Novartis Pharma GmbH, N├╝rnberg, Germany N/A This study seeks to investigate the role of pimecrolimus in restoring disturbed skin barrier function and reversing epidermal abnormalities found in atopic dermatitis (AD). The project is based on findings the investigators presented at the recent SID meeting in Providence and published in the J Invest Dermatol (122: 1423-31, 2004). The investigators research shows that AD is characterized by impaired skin barrier function, reduced stratum corneum hydration, impaired epidermal lipid composition and epidermal differentiation. In this proposed project, the investigators wish to examine the influence of pimecrolimus and betamethasone valerate on transepidermal water loss (TEWL) as a marker of the skin barrier function, on stratum corneum hydration, on stratum corneum lipid content and on epidermal differentiation regarding keratins and cornified envelope proteins in AD patients. The study involves biophysical measurements of TEWL and skin hydration, lipid analysis, immuno-histochemistry, Western blotting and micro array techniques. This study shall clarify whether pimecrolimus restores the epidermal barrier and whether this contributes to the beneficial effect of pimecrolimus on AD. Objectives: To explore the stratum corneum hydration, transepidermal water loss, capacity for barrier repair and the integrity of the stratum corneum in patients treated with 1 % pimecrolimus cream when applied twice a day to atopic dermatitis of the upper limbs, and to access the substance's influences on the epidermis through histological, ultra-structural, and biochemical analysis using punch biopsies from day 1 of one arm and day 22 from both treated arms. 0.1 % betamethasone valerate cream b.i.d will be used as a control treatment.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Betamethasone Valerate

Condition Name

Condition Name for Betamethasone Valerate
Intervention Trials
Psoriasis 3
Discoid Lupus Erythematosus 1
Dermatitis, Seborrheic 1
Dermatitis, Contact 1
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Condition MeSH

Condition MeSH for Betamethasone Valerate
Intervention Trials
Psoriasis 4
Dermatitis 2
Dermatitis, Atopic 2
Eczema 1
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Clinical Trial Locations for Betamethasone Valerate

Trials by Country

Trials by Country for Betamethasone Valerate
Location Trials
Germany 2
Iran, Islamic Republic of 1
France 1
Philippines 1
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Clinical Trial Progress for Betamethasone Valerate

Clinical Trial Phase

Clinical Trial Phase for Betamethasone Valerate
Clinical Trial Phase Trials
Phase 3 1
Phase 2 2
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for Betamethasone Valerate
Clinical Trial Phase Trials
Completed 4
Recruiting 1
Unknown status 1
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Clinical Trial Sponsors for Betamethasone Valerate

Sponsor Name

Sponsor Name for Betamethasone Valerate
Sponsor Trials
Deutsche Forschungsgemeinschaft, Bonn, Germany 1
Mantecorp Industria Quimica e Farmaceutica Ltd. 1
Galderma R&D 1
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Sponsor Type

Sponsor Type for Betamethasone Valerate
Sponsor Trials
Other 5
Industry 3
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