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Generated: December 11, 2018

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CLINICAL TRIALS PROFILE FOR BENDAMUSTINE HYDROCHLORIDE

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Clinical Trials for Bendamustine Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00069758 Safety and Activity of SDX-105 (Bendamustine) in Patients With Rituximab Refractory Non-Hodgkin's Lymphoma Completed Cephalon Phase 2 Summary: As this is an open label study, all patients will receive SDX-105 by 30-60 minute intravenous infusion on day 1 and day 2. Treatment will repeat every 21 days. Treatment can continue for up to one year in the absence of disease progression or unacceptable toxicity. Patients will be followed until disease progression. Rationale: Drugs used in chemotherapy, such as SDX-105, use different ways to stop tumor cells from dividing so they stop growing or die. Purpose: This study will evaluate the effectiveness and safety in non-Hodgkin's lymphoma in patients who are refractory to Rituxan.
NCT00076349 SDX-105 in Combination With Rituxan for Patients With Relapsed Indolent or Mantle Cell Non-Hodgkin's Lymphoma (NHL) Completed Cephalon Phase 2 SUMMARY: This is an open label study combining Rituxan and SDX-105. Rituxan will be given on day 1 followed by a 30-60 minute intravenous infusion of SDX-105 on day 2 and day 3. Treatment will repeat every 21 days (a cycle). Treatment can continue for up to 6 cycles (about 4 months) if tumor status improves and there are no unacceptable side effects. Patients will be followed for up to 2 years or until disease progression. RATIONALE: Rituxan has been shown to increase the sensitivity of cells to chemotherapy. The combination of SDX-105 and Rituxan has been effective in both the laboratory and in a recent clinical study with Non-Hodgkin's lymphoma patients. PURPOSE: This study will evaluate the safety and effectiveness of SDX-105 plus Rituxan in patients with Non-Hodgkin's lymphoma who have relapsed after taking Rituxan.
NCT00139841 Safety and Efficacy of Treanda™ (Bendamustine HCl) in Patients With Indolent Non-Hodgkin's Lymphoma (NHL) Who Are Refractory to Rituximab Completed Cephalon Phase 3 SUMMARY: This is a multi-center open label study to evaluate the safety and effectiveness of Treanda™ (also known as bendamustine HCl or SDX-105) in patients who have indolent Non-Hodgkin's lymphoma and have relapsed within a defined timeframe after taking rituximab (Rituxan®). Treanda will be given via 60-minute intravenous infusion on days 1 and 2 of every 21-day treatment cycle. Patients will be treated for 6 cycles unless they develop progressive disease or unacceptable toxicity. Those who continue to receive clinical benefit at end of 6 cycles may receive an additional 2 cycles. Following the end of treatment, patients will be followed for up to 2 years until disease progression or start of another anti-cancer therapy.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Bendamustine Hydrochloride

Condition Name

Condition Name for Bendamustine Hydrochloride
Intervention Trials
Chronic Lymphocytic Leukemia 43
Multiple Myeloma 28
Lymphoma 23
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Condition MeSH

Condition MeSH for Bendamustine Hydrochloride
Intervention Trials
Lymphoma 150
Leukemia, Lymphocytic, Chronic, B-Cell 75
Leukemia 73
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Clinical Trial Locations for Bendamustine Hydrochloride

Trials by Country

Trials by Country for Bendamustine Hydrochloride
Location Trials
United States 979
Italy 200
Canada 98
Spain 92
Australia 61
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Trials by US State

Trials by US State for Bendamustine Hydrochloride
Location Trials
Texas 55
New York 55
California 53
Ohio 39
Florida 39
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Clinical Trial Progress for Bendamustine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Bendamustine Hydrochloride
Clinical Trial Phase Trials
Phase 4 2
Phase 3 38
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Bendamustine Hydrochloride
Clinical Trial Phase Trials
Recruiting 83
Completed 72
Active, not recruiting 56
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Clinical Trial Sponsors for Bendamustine Hydrochloride

Sponsor Name

Sponsor Name for Bendamustine Hydrochloride
Sponsor Trials
Cephalon 33
National Cancer Institute (NCI) 22
M.D. Anderson Cancer Center 12
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Sponsor Type

Sponsor Type for Bendamustine Hydrochloride
Sponsor Trials
Other 227
Industry 211
NIH 22
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