The Natural History of Community-Associated MRSA Infections and Decolonization Strategies
Washington University School of Medicine
The purpose of this study is to determine the natural history of community-associated
Staphylococcus aureus infections in both adult and pediatric patients by monitoring the rate
of recurrent infections in those colonized with S. aureus.
In addition, this study will evaluate the efficiency of commonly prescribed decolonization
measures in patients presenting with S. aureus skin and soft tissue infections.
Efficacy, Safety, and Tolerability of TD1414 2% Cream in Impetigo and Secondarily Infected Traumatic Lesions (SITL)
An international, multi-centre, prospective three arm parallel-group, phase II proof of
concept study comparing the efficacy and safety of two dosage regimens (BID 7 days and TID 7
days) of TD1414 2% cream and one dosage regimen (BID 7 days) of Bactroban® (mupirocin) 2%
cream in adults and children down to 2 years of age with impetigo or SITL. Furthermore an
evaluation of the pharmacokinetics of TD1414 2% cream TID for 7 days will be performed. A
total of 664 patients will be enrolled in a stepwise manner according to age groups starting
with the oldest age group.
The purpose of this study is to determine whether measures to eliminate the Staph germ from
the skin of the index patient (with a special ointment and soap) are more effective when
performed by everyone in the household rather than the patient alone, and whether these
methods are effective in preventing future Staph infections. The investigators hypothesize
that there will be a greater number of households who are successful in eradicating the staph
germ from the index patient when all members of the household participate than households
where only the index patient is treated.
A Prospective Trial of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic Antibiotics for Prevention of Recurrent Methicillin Resistant Staphylococcus Aureus Infections
Natividad Medical Center
This clinical trial tests the hypothesis that body decolonization of patients with recurrent
community-associated (CA) MRSA infections will significantly reduce the likelihood of
recurrent CA-MRSA infection.
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