Remimazolam and Propofol Anesthesia in Elderly Patients
Not yet recruiting
Ajou University School of Medicine
N/A
2022-02-01
Remimazolam is a recently developed ultra-short agonist acting at the benzodiazepine binding
site of the gamma-aminobutyric acid (GABA)A receptor. Remimazolam has a combination of the
hemodynamic stability of benzodiazepines and the advantages of propofol, such as rapid onset,
short duration of action, and improved controllability.
A recent study showed that the efficacy of two induction doses of remimazolam (6 and 12
mg/kg/h) as a sedative for general anesthesia was not inferior to propofol (2.0-2.5 mg/kg),
and hemodynamically more stable. On the other hand, a study on the emergence time and quality
between propofol and remimazolam showed inconsistent results.
The purpose of this study is to compare remimazolam to propofol on the intraoperative
hemodynamic changes and recovery profiles, when used in combination with remifentanil in
elderly patients undergoing general anesthesia.
Remimazolam and Propofol on the Left Ventricular Strain During Anesthesia Induction for Non-cardiac Surgery
Not yet recruiting
Konkuk University Medical Center
Phase 4
2022-08-01
This study to compare the impacts of remimazolam or propofol on the left ventricular global
longitudinal strain (LV-GLS) during anesthesia induction for non-cardiac surgery.
LV-GLS is analyzed by using speckle tracking technique of transthoracic echocardiography.
Total Intravenous Anesthesia for Rigid Bronchoscopy Using Remimazolam
Not yet recruiting
Samsung Medical Center
N/A
2023-05-01
Rigid bronchoscopy usually requires deep general anesthesia, but the duration of the
procedure is relatively short. Remimazolam, a recently developed anesthetics, showed faster
recovery from anesthesia and stable hemodynamics compared to propofol, the most popular
anesthetics. However, few studies have investigated the usefulness of remimazolam for rigid
bronchoscopy. Therefore, the investigators compared the usefulness of propofol and
remimazolam in total intravenous anesthesia for rigid bronchoscopy.
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