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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR BRICANYL


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All Clinical Trials for BRICANYL

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00220259 ↗ Cystic Fibrosis Withdrawal of Inhaled Steroids Evaluation Study (CF WISE Study) Completed Cystic Fibrosis Trust N/A 2001-05-01 The overall aim of this study is to find out whether taking regular inhaled steroids (eg Pulmicort, Flixotide, Becotide, Becloforte) is good for the lungs of children and adults with cystic fibrosis (CF). Some patients are put on inhaled steroids because they are wheezy despite taking regular bronchodilators (inhaled medicines that help open up the airways eg Ventolin, Bricanyl). Occasionally young children are put on them when they wheeze with colds, and have simply remained on them ever since. However many CF patients have been put onto inhaled steroids because their doctors thought it might reduce the inflammation in the lungs and help improve lung function. This inflammation (which is swelling of the lining of the airways) is known to be important in CF and results from recurrent chest infections. Although it is believed, in theory, that inhaled steroids should be useful for most CF patients, we are not sure how well they work in CF and it has not yet been possible to prove this with standard studies. This would normally involve starting inhaled steroids in patients who have not been taking them. We have therefore taken a different approach, namely to withdraw them from some patients who have been on them for a long time, to see if there is any effect of stopping them. It is important that we answer this question, as we do not want CF patients taking medicines that may be unnecessary. CF patients already have to take many oral and inhaled medicines and if we can cut down this burden, it would be helpful for everyone. Of course, we may find that patients do need these medicines but at least we will then be certain that it is for a good reason. The main hypothesis is that withdrawing inhaled steroids is not associated with an earlier onset of acute chest exacerbations.
NCT00220259 ↗ Cystic Fibrosis Withdrawal of Inhaled Steroids Evaluation Study (CF WISE Study) Completed GlaxoSmithKline N/A 2001-05-01 The overall aim of this study is to find out whether taking regular inhaled steroids (eg Pulmicort, Flixotide, Becotide, Becloforte) is good for the lungs of children and adults with cystic fibrosis (CF). Some patients are put on inhaled steroids because they are wheezy despite taking regular bronchodilators (inhaled medicines that help open up the airways eg Ventolin, Bricanyl). Occasionally young children are put on them when they wheeze with colds, and have simply remained on them ever since. However many CF patients have been put onto inhaled steroids because their doctors thought it might reduce the inflammation in the lungs and help improve lung function. This inflammation (which is swelling of the lining of the airways) is known to be important in CF and results from recurrent chest infections. Although it is believed, in theory, that inhaled steroids should be useful for most CF patients, we are not sure how well they work in CF and it has not yet been possible to prove this with standard studies. This would normally involve starting inhaled steroids in patients who have not been taking them. We have therefore taken a different approach, namely to withdraw them from some patients who have been on them for a long time, to see if there is any effect of stopping them. It is important that we answer this question, as we do not want CF patients taking medicines that may be unnecessary. CF patients already have to take many oral and inhaled medicines and if we can cut down this burden, it would be helpful for everyone. Of course, we may find that patients do need these medicines but at least we will then be certain that it is for a good reason. The main hypothesis is that withdrawing inhaled steroids is not associated with an earlier onset of acute chest exacerbations.
NCT00220259 ↗ Cystic Fibrosis Withdrawal of Inhaled Steroids Evaluation Study (CF WISE Study) Completed Royal Brompton & Harefield NHS Foundation Trust N/A 2001-05-01 The overall aim of this study is to find out whether taking regular inhaled steroids (eg Pulmicort, Flixotide, Becotide, Becloforte) is good for the lungs of children and adults with cystic fibrosis (CF). Some patients are put on inhaled steroids because they are wheezy despite taking regular bronchodilators (inhaled medicines that help open up the airways eg Ventolin, Bricanyl). Occasionally young children are put on them when they wheeze with colds, and have simply remained on them ever since. However many CF patients have been put onto inhaled steroids because their doctors thought it might reduce the inflammation in the lungs and help improve lung function. This inflammation (which is swelling of the lining of the airways) is known to be important in CF and results from recurrent chest infections. Although it is believed, in theory, that inhaled steroids should be useful for most CF patients, we are not sure how well they work in CF and it has not yet been possible to prove this with standard studies. This would normally involve starting inhaled steroids in patients who have not been taking them. We have therefore taken a different approach, namely to withdraw them from some patients who have been on them for a long time, to see if there is any effect of stopping them. It is important that we answer this question, as we do not want CF patients taking medicines that may be unnecessary. CF patients already have to take many oral and inhaled medicines and if we can cut down this burden, it would be helpful for everyone. Of course, we may find that patients do need these medicines but at least we will then be certain that it is for a good reason. The main hypothesis is that withdrawing inhaled steroids is not associated with an earlier onset of acute chest exacerbations.
NCT00259766 ↗ SHARE - Symbicort and Health Economics in a Real Life Evaluation Completed AstraZeneca Phase 3 2004-04-01 The purpose of this study is to compare health-related costs and asthma control in ordinary clinical practice during 12 months for Symbicort® given as a low maintenance dose plus as needed compared to a free combination of Pulmicortâ and Oxis® plus Bricanyl® as needed, and Symbicort fixed dosing plus Bricanyl as needed in asthmatic patients not adequately controlled on inhaled glucocorticosteroids alone.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for BRICANYL

Condition Name

Condition Name for BRICANYL
Intervention Trials
Asthma 4
Acute Asthma 1
Acute Exacerbation of Chronic Obstructive Airways Disease 1
Cystic Fibrosis 1
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Condition MeSH

Condition MeSH for BRICANYL
Intervention Trials
Asthma 6
Pulmonary Disease, Chronic Obstructive 1
Fibrosis 1
Lung Diseases, Obstructive 1
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Clinical Trial Locations for BRICANYL

Trials by Country

Trials by Country for BRICANYL
Location Trials
Canada 10
Tunisia 3
Sweden 3
United Kingdom 2
Norway 1
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Trials by US State

Trials by US State for BRICANYL
Location Trials
New York 1
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Clinical Trial Progress for BRICANYL

Clinical Trial Phase

Clinical Trial Phase for BRICANYL
Clinical Trial Phase Trials
Phase 3 4
Phase 2/Phase 3 1
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for BRICANYL
Clinical Trial Phase Trials
Completed 7
Terminated 1
Unknown status 1
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Clinical Trial Sponsors for BRICANYL

Sponsor Name

Sponsor Name for BRICANYL
Sponsor Trials
AstraZeneca 4
University of Monastir 2
Cystic Fibrosis Trust 1
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Sponsor Type

Sponsor Type for BRICANYL
Sponsor Trials
Other 6
Industry 6
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