Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE)
The purpose of this study is:
1. To assess the efficacy of a lipid-lowering agent (atorvastatin) on the development of
atherosclerosis that predisposes children with SLE to cardiovascular events in
2. To assess the safety of intermediate-term (36 months) treatment of children and young
adults with atorvastatin.
3. To further characterize the course of SLE in children and young adults, by establishing
a cohort of pediatric SLE patients to be followed prospectively.
4. To establish a mechanism for conducting clinical trials in rare pediatric rheumatic
diseases using the Children's Arthritis and Rheumatology Research Alliance (CARRA).
CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients
The purpose of the study is to evaluate the effects of two phosphate binders, PhosLo and
sevelamer, on heart calcification in dialysis patients. The study will use a non-invasive
technique, electron beam computed tomography (CT) scanning, to measure calcium in the
coronary arteries, the aortic valve, and the mitral valve.
Study to Evaluate the Long-Term Safety and Efficacy of ABT-335, in Combination With Three Different Statins in Subjects With Mixed Dyslipidemia.
The primary purpose of this study is to test the safety and the effects of using an
investigational drug regimen; once daily ABT-335 (Investigational drug) administered in
combination with once daily atorvastatin calcium, rosuvastatin calcium or simvastatin in
patients with abnormal lipid levels in the blood.
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