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Last Updated: May 17, 2022

CLINICAL TRIALS PROFILE FOR ASCORBIC ACID


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505(b)(2) Clinical Trials for Ascorbic Acid

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
New Dosage NCT01533090 ↗ Evaluation of Reduced-volume PEG Bowel Preparation Administered the Same Day of Colonoscopy Completed Catholic University of the Sacred Heart N/A 2010-04-01 The conventional total dose of 4 L of polyethylene glycol (PEG) given the day before the procedure is safe and effective. It has been the standard cleansing regimen for the last 25 years. To overcome the difficulty in completing the bowel preparation due to large volume and/or taste, reduced-volume (mixed) bowel preparation of bisacodyl and 2 L of PEG have been shown to provide adequate colon cleansing and better tolerability. LoVol-esse is a reduced-volume PEG-based bowel preparation to be used in combination with bisacodyl and designed to improve patient tolerability and attitude toward bowel cleansing prior to colonoscopy thanks to the reduced volume and improved taste. The present study is intended to compare the new dosing regimen of the bowel lavage solution given the same day compared with standard PEG formulation (SELG 1000) given the day before colonoscopy.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Ascorbic Acid

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000595 ↗ Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 2 1978-01-01 To determine whether deferoxamine prevented the complications of transfusional iron overload.
NCT00006021 ↗ Arsenic Trioxide Plus Vitamin C in Treating Patients With Recurrent or Refractory Multiple Myeloma Completed National Cancer Institute (NCI) Phase 1/Phase 2 2000-06-01 RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Vitamin C may increase the effectiveness of arsenic trioxide by making cancer cells more sensitive to the drug. PURPOSE: Phase I/II trial to determine the effectiveness of arsenic trioxide plus vitamin C in treating patients who have recurrent or refractory multiple myeloma.
NCT00006021 ↗ Arsenic Trioxide Plus Vitamin C in Treating Patients With Recurrent or Refractory Multiple Myeloma Completed University of Miami Phase 1/Phase 2 2000-06-01 RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Vitamin C may increase the effectiveness of arsenic trioxide by making cancer cells more sensitive to the drug. PURPOSE: Phase I/II trial to determine the effectiveness of arsenic trioxide plus vitamin C in treating patients who have recurrent or refractory multiple myeloma.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Ascorbic Acid

Condition Name

Condition Name for Ascorbic Acid
Intervention Trials
Sepsis 10
Septic Shock 9
Colonoscopy 7
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Condition MeSH

Condition MeSH for Ascorbic Acid
Intervention Trials
Multiple Myeloma 13
Pancreatic Neoplasms 12
Neoplasms, Plasma Cell 11
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Clinical Trial Locations for Ascorbic Acid

Trials by Country

Trials by Country for Ascorbic Acid
Location Trials
United States 132
Korea, Republic of 22
Spain 11
Egypt 7
Italy 6
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Trials by US State

Trials by US State for Ascorbic Acid
Location Trials
Pennsylvania 12
New York 10
California 10
Arizona 8
Massachusetts 7
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Clinical Trial Progress for Ascorbic Acid

Clinical Trial Phase

Clinical Trial Phase for Ascorbic Acid
Clinical Trial Phase Trials
Phase 4 33
Phase 3 30
Phase 2/Phase 3 7
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Clinical Trial Status

Clinical Trial Status for Ascorbic Acid
Clinical Trial Phase Trials
Completed 103
Unknown status 24
Recruiting 23
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Clinical Trial Sponsors for Ascorbic Acid

Sponsor Name

Sponsor Name for Ascorbic Acid
Sponsor Trials
National Cancer Institute (NCI) 13
Thomas Jefferson University 7
Seoul National University Hospital 5
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Sponsor Type

Sponsor Type for Ascorbic Acid
Sponsor Trials
Other 302
Industry 37
NIH 21
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