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Generated: December 12, 2018

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CLINICAL TRIALS PROFILE FOR ANGIOMAX

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Clinical Trials for Angiomax

Trial ID Title Status Sponsor Phase Summary
NCT00043277 Study Of Angiomax In Infants Under Six Months With Thrombosis Completed The Medicines Company Phase 2 The goals of this study are: 1. To assess the safety of bivalirudin in infants under six months with arterial or venous thrombosis; 2. To determine the dose of bivalirudin required to achieve adequate anticoagulation as measured by the activated clotting time (ACT) or activated partial thromboplastin time (aPTT) in Infants Under Six Months with arterial or venous thrombosis; 3. To determine the outcome of patients on bivalirudin with respect to thrombus resolution and bleeding complications compared to patients on unfractionated heparin (UH) or low molecular weight heparin (LMWH).
NCT00073580 Angiomax in Patients With HIT/HITTS Type II Undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) (CHOOSE) Unknown status The Medicines Company Phase 3 The purpose of this study is to examine the safety and efficacy of Angiomax as an anticoagulation in patients with heparin-induced thrombocytopenia (HIT)/heparin-induced thrombocytopenia with thrombosis syndrome (HITTS) undergoing off-pump coronary artery bypass (OPCAB) surgery.
NCT00073593 Comparing Angiomax to Heparin With Protamine Reversal in Patients OPCAB Completed The Medicines Company Phase 3 The purpose of this study is to examine the safety and efficacy of Angiomax as an alternative anticoagulant to heparin with protamine reversal in patients undergoing off-pump coronary artery bypass graft surgery.
NCT00079508 Angiomax in Patients With HIT/HITTS Type II Undergoing CPB Completed The Medicines Company Phase 3 The purpose of this study is to demonstrate that in patients with heparin-induced thrombocytopenia (HIT)/heparin-induced thrombocytopenia and thrombosis syndrome (HITTS) Type II undergoing cardiac surgery on cardiopulmonary bypass (CPB), Angiomax is a safe and effective anticoagulant.
NCT00079586 Comparing Angiomax to Heparin With Protamine in Patients Undergoing Cardiopulmonary Bypass (CPB) Completed The Medicines Company Phase 3 The purpose of this study is to demonstrate that in patients undergoing coronary artery bypass grafting (CABG) or CABG-Valve, or Isolated Cardiac Valve surgery on CPB (cardiac surgery), Angiomax is a safe and effective alternative anticoagulant to heparin with protamine reversal.
NCT00093158 Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes (ACS) Completed The Medicines Company Phase 3 The purpose of this study is to show that, when compared with heparin (enoxaparin or unfractionated heparin) and routine GPIIb/IIIa inhibition (either started upfront or at the time of percutaneous coronary intervention [PCI]; Arm A): 1. Bivalirudin with routine GPIIb/IIIa inhibition (either started upfront or at the time of PCI; Arm B) provides non-inferior or superior overall clinical outcomes and 2. Bivalirudin alone (Arm C) reduces clinically significant bleeding. An important secondary objective for this comparison is to show that bivalirudin is not inferior for ischemic complications.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Angiomax

Condition Name

Condition Name for Angiomax
Intervention Trials
Coronary Artery Bypass Surgery 4
Thrombosis 2
Cardiovascular Disease 2
Coronary Heart Disease 1
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Condition MeSH

Condition MeSH for Angiomax
Intervention Trials
Acute Coronary Syndrome 2
Coronary Artery Disease 2
Cardiovascular Diseases 2
Heart Diseases 2
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Clinical Trial Locations for Angiomax

Trials by Country

Trials by Country for Angiomax
Location Trials
United States 34
Canada 2
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Trials by US State

Trials by US State for Angiomax
Location Trials
Ohio 5
New York 4
North Carolina 2
Florida 2
California 2
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Clinical Trial Progress for Angiomax

Clinical Trial Phase

Clinical Trial Phase for Angiomax
Clinical Trial Phase Trials
Phase 4 1
Phase 3 7
Phase 2 3
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Clinical Trial Status

Clinical Trial Status for Angiomax
Clinical Trial Phase Trials
Completed 7
Terminated 1
Active, not recruiting 1
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Clinical Trial Sponsors for Angiomax

Sponsor Name

Sponsor Name for Angiomax
Sponsor Trials
The Medicines Company 8
Qian Gong 1
Stony Brook University 1
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Sponsor Type

Sponsor Type for Angiomax
Sponsor Trials
Industry 9
Other 3
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Serving hundreds of leading biopharmaceutical companies globally:

Fish and Richardson
Dow
AstraZeneca
Cerilliant
Farmers Insurance
Colorcon
Fuji
Chubb
Queensland Health

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