Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)
Completed
National Heart, Lung, and Blood Institute (NHLBI)
Phase 3
1987-04-01
To compare the efficacy of amiodarone to conventional anti-arrhythmic therapy in individuals
who had survived one episode of out-of-hospital cardiac arrest.
Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)
Completed
University of Washington
Phase 3
1987-04-01
To compare the efficacy of amiodarone to conventional anti-arrhythmic therapy in individuals
who had survived one episode of out-of-hospital cardiac arrest.
Antiarrhythmics Versus Implantable Defibrillators (AVID)
Completed
National Heart, Lung, and Blood Institute (NHLBI)
Phase 3
1992-09-01
To evaluate if use of an implantable cardiac defibrillator (ICD) results in reduction in
total mortality, when compared with conventional pharmacological therapy, in patients
resuscitated from sudden cardiac death who are otherwise at very high risk of mortality from
arrhythmic causes.
Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
Completed
National Heart, Lung, and Blood Institute (NHLBI)
Phase 3
1995-03-01
To compare two standard treatment strategies for atrial fibrillation: ventricular rate
control and anticoagulation vs. rhythm control and anticoagulation.
Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
Completed
National Heart, Lung, and Blood Institute (NHLBI)
Phase 3
1997-05-01
To compare conventional treatment of congestive heart failure (CHF) with two experimental
interventions: amiodarone and an implantable cardioverter-defibrillator (ICD).
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